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Title: Ultrasonic analyte concentration and application in flow cytometry

Abstract

The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.

Inventors:
 [1];  [1];  [2];  [1];  [1];  [1];  [3]
  1. Los Alamos, NM
  2. White Rock, NM
  3. San Juan Pueblo, NM
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
936222
Patent Number(s):
7340957
Application Number:
10/979,065
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Kaduchak, Gregory, Goddard, Greg, Salzman, Gary, Sinha, Dipen, Martin, John C, Kwiatkowski, Christopher, and Graves, Steven. Ultrasonic analyte concentration and application in flow cytometry. United States: N. p., 2008. Web.
Kaduchak, Gregory, Goddard, Greg, Salzman, Gary, Sinha, Dipen, Martin, John C, Kwiatkowski, Christopher, & Graves, Steven. Ultrasonic analyte concentration and application in flow cytometry. United States.
Kaduchak, Gregory, Goddard, Greg, Salzman, Gary, Sinha, Dipen, Martin, John C, Kwiatkowski, Christopher, and Graves, Steven. Tue . "Ultrasonic analyte concentration and application in flow cytometry". United States. https://www.osti.gov/servlets/purl/936222.
@article{osti_936222,
title = {Ultrasonic analyte concentration and application in flow cytometry},
author = {Kaduchak, Gregory and Goddard, Greg and Salzman, Gary and Sinha, Dipen and Martin, John C and Kwiatkowski, Christopher and Graves, Steven},
abstractNote = {The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {3}
}

Patent:

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Works referenced in this record:

A numerically stable global matrix method for cylindrically layered shells excited by ring forces
journal, June 1994


On the Acoustic Radiation Pressure on Spheres
journal, November 1934


Migration of suspended particles in plane stationary ultrasonic field
journal, January 1981