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Title: Synthesis of isotopically labeled R- or S-[.sup.13C, .sup.2H] glycerols

Abstract

The present invention is directed to asymmetric chiral labeled glycerols including at least one chiral atom, from one to two .sup.13C atoms and from zero to four deuterium atoms bonded directly to a carbon atom, e.g., (2S) [1,2-.sup.13C.sub.2]glycerol and (2R) [1,2-.sup.13C.sub.2]glycerol, and to the use of such chiral glycerols in the preparation of labeled amino acids.

Inventors:
 [1];  [2];  [1]
  1. Santa Fe, NM
  2. Los Alamos, NM
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
927842
Patent Number(s):
7321070
Application Number:
10/629,982
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Martinez, Rodolfo A, Unkefer, Clifford J, and Alvarez, Marc A. Synthesis of isotopically labeled R- or S-[.sup.13C, .sup.2H] glycerols. United States: N. p., 2008. Web.
Martinez, Rodolfo A, Unkefer, Clifford J, & Alvarez, Marc A. Synthesis of isotopically labeled R- or S-[.sup.13C, .sup.2H] glycerols. United States.
Martinez, Rodolfo A, Unkefer, Clifford J, and Alvarez, Marc A. Tue . "Synthesis of isotopically labeled R- or S-[.sup.13C, .sup.2H] glycerols". United States. https://www.osti.gov/servlets/purl/927842.
@article{osti_927842,
title = {Synthesis of isotopically labeled R- or S-[.sup.13C, .sup.2H] glycerols},
author = {Martinez, Rodolfo A and Unkefer, Clifford J and Alvarez, Marc A},
abstractNote = {The present invention is directed to asymmetric chiral labeled glycerols including at least one chiral atom, from one to two .sup.13C atoms and from zero to four deuterium atoms bonded directly to a carbon atom, e.g., (2S) [1,2-.sup.13C.sub.2]glycerol and (2R) [1,2-.sup.13C.sub.2]glycerol, and to the use of such chiral glycerols in the preparation of labeled amino acids.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {1}
}

Patent:

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Works referenced in this record:

A short synthesis of (1S,2R)- and (1R,2R)-[1-2H]-glycerols
journal, July 1997


Synthesis of asymmetrically deuterated glycerol and dibenzyl glyceraldehyde via boronic esters
journal, May 1990


Some aspects of the stereochemistry and biosynthesis of asukamycin
journal, December 1993