Cleavage of nucleic acids
Abstract
The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
- Inventors:
-
- Madison, WI
- Issue Date:
- Research Org.:
- Third Wave Technologies, Inc. (Madison, WI)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 921021
- Patent Number(s):
- 7306917
- Application Number:
- 11/222,565
- Assignee:
- Third Wave Technologies, Inc. (Madison, WI)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- FG02-94ER81891
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Prudent, James R, Hall, Jeff G, Lyamichev, Victor L, Brow, Mary Ann D, and Dahlberg, James E. Cleavage of nucleic acids. United States: N. p., 2007.
Web.
Prudent, James R, Hall, Jeff G, Lyamichev, Victor L, Brow, Mary Ann D, & Dahlberg, James E. Cleavage of nucleic acids. United States.
Prudent, James R, Hall, Jeff G, Lyamichev, Victor L, Brow, Mary Ann D, and Dahlberg, James E. Tue .
"Cleavage of nucleic acids". United States. https://www.osti.gov/servlets/purl/921021.
@article{osti_921021,
title = {Cleavage of nucleic acids},
author = {Prudent, James R and Hall, Jeff G and Lyamichev, Victor L and Brow, Mary Ann D and Dahlberg, James E},
abstractNote = {The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {12}
}
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