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Title: Recombinant constructs of Borrelia burgdorferi

Abstract

Novel chimeric nucleic acids, encoding chimeric Borrelia proteins comprising OspC or an antigenic fragment thereof and OspA or an antigenic fragment thereof, are disclosed. Chimeric proteins encoded by the nucleic acid sequences are also disclosed. The chimeric proteins are useful as vaccine immunogens against Lyme borreliosis, as well as for immunodiagnostic reagents.

Inventors:
 [1];  [2];  [3];  [4]
  1. Setauket, NY
  2. New York, NY
  3. East Setauket, NY
  4. Bellport, NY
Issue Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
919842
Patent Number(s):
7179448
Assignee:
Research Foundation of the State of New York (Stony Brook, NY); Brookhaven Sciences Associates, LLC (Upton, NY)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Dattwyler, Raymond J, Gomes-Solecki, Maria J. C., Luft, Benjamin J, and Dunn, John J. Recombinant constructs of Borrelia burgdorferi. United States: N. p., 2007. Web.
Dattwyler, Raymond J, Gomes-Solecki, Maria J. C., Luft, Benjamin J, & Dunn, John J. Recombinant constructs of Borrelia burgdorferi. United States.
Dattwyler, Raymond J, Gomes-Solecki, Maria J. C., Luft, Benjamin J, and Dunn, John J. Tue . "Recombinant constructs of Borrelia burgdorferi". United States. https://www.osti.gov/servlets/purl/919842.
@article{osti_919842,
title = {Recombinant constructs of Borrelia burgdorferi},
author = {Dattwyler, Raymond J and Gomes-Solecki, Maria J. C. and Luft, Benjamin J and Dunn, John J},
abstractNote = {Novel chimeric nucleic acids, encoding chimeric Borrelia proteins comprising OspC or an antigenic fragment thereof and OspA or an antigenic fragment thereof, are disclosed. Chimeric proteins encoded by the nucleic acid sequences are also disclosed. The chimeric proteins are useful as vaccine immunogens against Lyme borreliosis, as well as for immunodiagnostic reagents.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {2}
}

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Works referenced in this record:

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  • https://doi.org/10.1016/S0176-6724(86)80101-8

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Disarming Lyme Disease
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