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Title: Computational model, method, and system for kinetically-tailoring multi-drug chemotherapy for individuals

Abstract

A method and system for tailoring treatment regimens to individual patients with diseased cells exhibiting evolution of resistance to such treatments. A mathematical model is provided which models rates of population change of proliferating and quiescent diseased cells using cell kinetics and evolution of resistance of the diseased cells, and pharmacokinetic and pharmacodynamic models. Cell kinetic parameters are obtained from an individual patient and applied to the mathematical model to solve for a plurality of treatment regimens, each having a quantitative efficacy value associated therewith. A treatment regimen may then be selected from the plurlaity of treatment options based on the efficacy value.

Inventors:
 [1]
  1. San Leandro, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
919066
Patent Number(s):
7286970
Application Number:
10/338,559
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
G - PHYSICS G06 - COMPUTING G06F - ELECTRIC DIGITAL DATA PROCESSING
G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16H - HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Gardner, Shea Nicole. Computational model, method, and system for kinetically-tailoring multi-drug chemotherapy for individuals. United States: N. p., 2007. Web.
Gardner, Shea Nicole. Computational model, method, and system for kinetically-tailoring multi-drug chemotherapy for individuals. United States.
Gardner, Shea Nicole. Tue . "Computational model, method, and system for kinetically-tailoring multi-drug chemotherapy for individuals". United States. https://www.osti.gov/servlets/purl/919066.
@article{osti_919066,
title = {Computational model, method, and system for kinetically-tailoring multi-drug chemotherapy for individuals},
author = {Gardner, Shea Nicole},
abstractNote = {A method and system for tailoring treatment regimens to individual patients with diseased cells exhibiting evolution of resistance to such treatments. A mathematical model is provided which models rates of population change of proliferating and quiescent diseased cells using cell kinetics and evolution of resistance of the diseased cells, and pharmacokinetic and pharmacodynamic models. Cell kinetic parameters are obtained from an individual patient and applied to the mathematical model to solve for a plurality of treatment regimens, each having a quantitative efficacy value associated therewith. A treatment regimen may then be selected from the plurlaity of treatment options based on the efficacy value.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {10}
}

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Works referenced in this record:

Optimizing Drug Regimens in Cancer Chemotherapy by an Efficacy–Toxicity Mathematical Model
journal, June 2000