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Title: Apolipoprotein gene involved in lipid metabolism

Abstract

Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.

Inventors:
 [1];  [2]
  1. Berkeley, CA
  2. Sebastopol, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
Office of Biological and Environmental Research
OSTI Identifier:
913257
Patent Number(s):
7238475
Application Number:
10/229,834
Assignee:
The Regents of The University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Rubin, Edward, and Pennacchio, Len A. Apolipoprotein gene involved in lipid metabolism. United States: N. p., 2007. Web.
Rubin, Edward, & Pennacchio, Len A. Apolipoprotein gene involved in lipid metabolism. United States.
Rubin, Edward, and Pennacchio, Len A. Tue . "Apolipoprotein gene involved in lipid metabolism". United States. https://www.osti.gov/servlets/purl/913257.
@article{osti_913257,
title = {Apolipoprotein gene involved in lipid metabolism},
author = {Rubin, Edward and Pennacchio, Len A},
abstractNote = {Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {7}
}

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Works referenced in this record:

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DNA polymorphisms of apolipoprotein A-I/C-III and insulin genes in familial hypertriglyceridemia and coronary heart disease
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The essence of SNPs
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Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels
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Genetic variation in the apolipoprotein AI-CIII-AIV gene cluster and coronary heart disease
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Haplotypes of the ApoA-I/C-III/A-IV Gene Cluster and Familial Combined Hyperlipidemia
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Dna Polymorphism Adjacent to Human Apoprotein a-1 Gene: Relation to Hypertriglyceridaemia
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The apoAI-CIII-AIV gene cluster
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A Genome Scan for Familial Combined Hyperlipidemia Reveals Evidence of Linkage with a Locus on Chromosome 11
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An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3' untranslated region polymorphisms.
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Regression of Atherosclerosis Induced by Liver-Directed Gene Transfer of Apolipoprotein A-I in Mice
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HTS in the new millennium
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Two newly identified SNPs in the APO AI-CIII intergenic region are strongly associated with familial combined hyperlipidaemia
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Variation at the apo AI/CIII/A1V gene complex is associated with elevated plasma levels of apo CIII
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