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Title: Foldable polymers as probes

Abstract

Disclosed herein are novel probes, which can be used to detect and identify target molecules of interest in a sample. The disclosed probes can be used to monitor conformational changes induced by molecular recognition events in addition to providing signaling the presence and/or identity of a target molecule. Methods, including solid phase synthesis techniques, for making probe molecules that exhibit changes in their optical properties upon target molecule binding are described in the disclosure. Also disclosed herein are novel chromophore moieties, which have tailored fluorescent emission spectra.

Inventors:
 [1];  [1]
  1. Pullman, WA
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
913254
Patent Number(s):
7238792
Application Number:
10/803,564
Assignee:
Washington State University Research Foundation (Pullman, WA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
C - CHEMISTRY C40 - COMBINATORIAL TECHNOLOGY C40B - COMBINATORIAL CHEMISTRY
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Li, Alexander D. Q., and Wang, Wei. Foldable polymers as probes. United States: N. p., 2007. Web.
Li, Alexander D. Q., & Wang, Wei. Foldable polymers as probes. United States.
Li, Alexander D. Q., and Wang, Wei. Tue . "Foldable polymers as probes". United States. https://www.osti.gov/servlets/purl/913254.
@article{osti_913254,
title = {Foldable polymers as probes},
author = {Li, Alexander D. Q. and Wang, Wei},
abstractNote = {Disclosed herein are novel probes, which can be used to detect and identify target molecules of interest in a sample. The disclosed probes can be used to monitor conformational changes induced by molecular recognition events in addition to providing signaling the presence and/or identity of a target molecule. Methods, including solid phase synthesis techniques, for making probe molecules that exhibit changes in their optical properties upon target molecule binding are described in the disclosure. Also disclosed herein are novel chromophore moieties, which have tailored fluorescent emission spectra.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {7}
}

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Works referenced in this record:

Folding versus Self-Assembling
journal, October 2003


Alternating DNA and π-Conjugated Sequences. Thermophilic Foldable Polymers
journal, May 2003


To Fold or to Assemble?
journal, February 2003


Molecular Beacons: Probes that Fluoresce upon Hybridization
journal, March 1996


Molecular beacon aptamer fluoresces in the presence of Tat protein of HIV-1
journal, May 2000