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Title: Modified cellulose synthase gene from Arabidopsis thaliana confers herbicide resistance to plants

Abstract

Cellulose synthase ("CS"), a key enzyme in the biosynthesis of cellulose in plants is inhibited by herbicides comprising thiazolidinones such as 5-tert-butyl-carbamoyloxy-3-(3-trifluromethyl)phenyl-4-thiazolidinone (TZ), isoxaben and 2,6-dichlorobenzonitrile (DCB). Two mutant genes encoding isoxaben and TZ-resistant cellulose synthase have been isolated from isoxaben and TZ-resistant Arabidopsis thaliana mutants. When compared with the gene coding for isoxaben or TZ-sensitive cellulose synthase, one of the resistant CS genes contains a point mutation, wherein glycine residue 998 is replaced by an aspartic acid. The other resistant mutation is due to a threonine to isoleucine change at amino acid residue 942. The mutant CS gene can be used to impart herbicide resistance to a plant; thereby permitting the utilization of the herbicide as a single application at a concentration which ensures the complete or substantially complete killing of weeds, while leaving the transgenic crop plant essentially undamaged.

Inventors:
 [1];  [2]
  1. Portola Valley, CA
  2. Golm, DE
Issue Date:
Research Org.:
Carnegie Institute of Washington
Sponsoring Org.:
USDOE
OSTI Identifier:
912868
Patent Number(s):
7,241,878
Application Number:
10/721,996
Assignee:
U.S. Department of Energy (Washington, DC)
DOE Contract Number:  
FG02-94ER20133
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Somerville, Chris R, and Scheible, Wolf. Modified cellulose synthase gene from Arabidopsis thaliana confers herbicide resistance to plants. United States: N. p., 2007. Web.
Somerville, Chris R, & Scheible, Wolf. Modified cellulose synthase gene from Arabidopsis thaliana confers herbicide resistance to plants. United States.
Somerville, Chris R, and Scheible, Wolf. Tue . "Modified cellulose synthase gene from Arabidopsis thaliana confers herbicide resistance to plants". United States. https://www.osti.gov/servlets/purl/912868.
@article{osti_912868,
title = {Modified cellulose synthase gene from Arabidopsis thaliana confers herbicide resistance to plants},
author = {Somerville, Chris R and Scheible, Wolf},
abstractNote = {Cellulose synthase ("CS"), a key enzyme in the biosynthesis of cellulose in plants is inhibited by herbicides comprising thiazolidinones such as 5-tert-butyl-carbamoyloxy-3-(3-trifluromethyl)phenyl-4-thiazolidinone (TZ), isoxaben and 2,6-dichlorobenzonitrile (DCB). Two mutant genes encoding isoxaben and TZ-resistant cellulose synthase have been isolated from isoxaben and TZ-resistant Arabidopsis thaliana mutants. When compared with the gene coding for isoxaben or TZ-sensitive cellulose synthase, one of the resistant CS genes contains a point mutation, wherein glycine residue 998 is replaced by an aspartic acid. The other resistant mutation is due to a threonine to isoleucine change at amino acid residue 942. The mutant CS gene can be used to impart herbicide resistance to a plant; thereby permitting the utilization of the herbicide as a single application at a concentration which ensures the complete or substantially complete killing of weeds, while leaving the transgenic crop plant essentially undamaged.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {7}
}

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