Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres

Zhou, Feng; Nolan, John P

Title: Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres

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Abstract

The present invention is directed to processes of separating, analyzing and/or collecting selected species within a target sample by use of magnetic microspheres including magnetic particles, the magnetic microspheres adapted for attachment to a receptor agent that can subsequently bind to selected species within the target sample. The magnetic microspheres can be sorted into a number of distinct populations, each population with a specific range of magnetic moments and different receptor agents can be attached to each distinct population of magnetic microsphere.

Inventors:

Kraus, Jr., Robert H. ^[1]; Zhou, Feng ^[2]; Nolan, John P ^[3]

(Los Alamos, NM)
Los Alamos, NM
Santa Fe, NM

Issue Date:: 2007-06-19

Research Org.:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 909705

Patent Number(s):: 7232691

Application Number:: 09/995,304

Assignee:: Los Alamos National Security, LLC (Los Alamos, NM)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B03 - SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS B03C - MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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B - PERFORMING OPERATIONS B03 - SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS B03C - MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS
B03C1/00 - Magnetic separation

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N2015/0288 - {Sorting the particles}
G01N27/745 - {for detecting magnetic beads used in biochemical assays
G01N33/54326 - {Magnetic particles}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/115831 - Condition or time responsive
Y10T436/12 - Condition responsive control

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DOE Contract Number:: W-7405-ENG-36

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Kraus, Jr., Robert H., Zhou, Feng, and Nolan, John P. Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres.  United States: N. p., 2007. 
        Web.

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                    Kraus, Jr., Robert H., Zhou, Feng, & Nolan, John P. Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres.  United States.

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                    Kraus, Jr., Robert H., Zhou, Feng, and Nolan, John P. Tue .  
        "Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres".  United States.  https://www.osti.gov/servlets/purl/909705.

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@article{osti_909705,

  title        = {Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres},

  author       = {Kraus, Jr., Robert H. and Zhou, Feng and Nolan, John P},

  abstractNote = {The present invention is directed to processes of separating, analyzing and/or collecting selected species within a target sample by use of magnetic microspheres including magnetic particles, the magnetic microspheres adapted for attachment to a receptor agent that can subsequently bind to selected species within the target sample. The magnetic microspheres can be sorted into a number of distinct populations, each population with a specific range of magnetic moments and different receptor agents can be attached to each distinct population of magnetic microsphere.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2007},

  month        = {6}

}

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