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Title: Fermentation process using specific oxygen uptake rates as a process control

Abstract

Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.

Inventors:
; ;
Issue Date:
Research Org.:
Cargill Dow Polymers LLC
Sponsoring Org.:
USDOE
OSTI Identifier:
909704
Patent Number(s):
7232664
Application Number:
10/449,911
Assignee:
NatureWorks LLC (Minnetonka, MN)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02P - CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
FC36-00GO10598
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Van Hoek, Pim, Aristidou, Aristos, and Rush, Brian. Fermentation process using specific oxygen uptake rates as a process control. United States: N. p., 2007. Web.
Van Hoek, Pim, Aristidou, Aristos, & Rush, Brian. Fermentation process using specific oxygen uptake rates as a process control. United States.
Van Hoek, Pim, Aristidou, Aristos, and Rush, Brian. Tue . "Fermentation process using specific oxygen uptake rates as a process control". United States. https://www.osti.gov/servlets/purl/909704.
@article{osti_909704,
title = {Fermentation process using specific oxygen uptake rates as a process control},
author = {Van Hoek, Pim and Aristidou, Aristos and Rush, Brian},
abstractNote = {Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {6}
}

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Works referenced in this record:

Replacement of a Metabolic Pathway for Large-Scale Production of Lactic Acid from Engineered Yeasts
journal, September 1999


Development of metabolically engineered Saccharomyces cerevisiae cells for the production of lactic acid
journal, May 1995