pH-sensitive methacrylic copolymer gels and the production thereof
Abstract
The present invention provides novel gel forming methacrylic blocking copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility. The copolymers are constructed by polymerization of a tertiary amine methacrylate with either a (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) polymer, such as the commercially available Pluronic.RTM. polymers, or a poly(ethylene glycol)methyl ether polymer. The polymers may be used for drug and gene delivery, protein separation, as structural supplements, and more.
- Inventors:
-
- Ames, IA
- Lake Bluff, IA
- Issue Date:
- Research Org.:
- Ames Laboratory (AMES), Ames, IA
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 909395
- Patent Number(s):
- 7217776
- Application Number:
- 10/366,864
- Assignee:
- Iowa State University Research Foundation (Ames, IA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- DOE Contract Number:
- W-7405-ENG-82
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Mallapragada, Surya K, and Anderson, Brian C. pH-sensitive methacrylic copolymer gels and the production thereof. United States: N. p., 2007.
Web.
Mallapragada, Surya K, & Anderson, Brian C. pH-sensitive methacrylic copolymer gels and the production thereof. United States.
Mallapragada, Surya K, and Anderson, Brian C. Tue .
"pH-sensitive methacrylic copolymer gels and the production thereof". United States. https://www.osti.gov/servlets/purl/909395.
@article{osti_909395,
title = {pH-sensitive methacrylic copolymer gels and the production thereof},
author = {Mallapragada, Surya K and Anderson, Brian C},
abstractNote = {The present invention provides novel gel forming methacrylic blocking copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility. The copolymers are constructed by polymerization of a tertiary amine methacrylate with either a (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) polymer, such as the commercially available Pluronic.RTM. polymers, or a poly(ethylene glycol)methyl ether polymer. The polymers may be used for drug and gene delivery, protein separation, as structural supplements, and more.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {5}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Influence of polymer architecture on the structure of complexes formed by PEG–tertiary amine methacrylate copolymers and phosphorothioate oligonucleotide
journal, May 2002
- Deshpande, Mangesh C.; Garnett, Martin C.; Vamvakaki, M.
- Journal of Controlled Release, Vol. 81, Issue 1-2
Synthesis of Controlled Structure Water-Soluble Diblock Copolymers via Oxyanionic Polymerization
journal, March 1999
- Vamvakaki, M.; Billingham, N. C.; Armes, S. P.
- Macromolecules, Vol. 32, Issue 6
Structure of pH-Dependent Block Copolymer Micelles: Charge and Ionic Strength Dependence
journal, October 2002
- Lee, Albert S.; Bütün, Vural; Vamvakaki, M.
- Macromolecules, Vol. 35, Issue 22