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Title: pH-sensitive methacrylic copolymer gels and the production thereof

Abstract

The present invention provides novel gel forming methacrylic blocking copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility. The copolymers are constructed by polymerization of a tertiary amine methacrylate with either a (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) polymer, such as the commercially available Pluronic.RTM. polymers, or a poly(ethylene glycol)methyl ether polymer. The polymers may be used for drug and gene delivery, protein separation, as structural supplements, and more.

Inventors:
 [1];  [2]
  1. Ames, IA
  2. Lake Bluff, IA
Issue Date:
Research Org.:
Ames Lab., Ames, IA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
909395
Patent Number(s):
7217776
Application Number:
10/366,864
Assignee:
Iowa State University Research Foundation (Ames, IA)
Patent Classifications (CPCs):
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
DOE Contract Number:  
W-7405-ENG-82
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Mallapragada, Surya K, and Anderson, Brian C. pH-sensitive methacrylic copolymer gels and the production thereof. United States: N. p., 2007. Web.
Mallapragada, Surya K, & Anderson, Brian C. pH-sensitive methacrylic copolymer gels and the production thereof. United States.
Mallapragada, Surya K, and Anderson, Brian C. Tue . "pH-sensitive methacrylic copolymer gels and the production thereof". United States. https://www.osti.gov/servlets/purl/909395.
@article{osti_909395,
title = {pH-sensitive methacrylic copolymer gels and the production thereof},
author = {Mallapragada, Surya K and Anderson, Brian C},
abstractNote = {The present invention provides novel gel forming methacrylic blocking copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility. The copolymers are constructed by polymerization of a tertiary amine methacrylate with either a (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) polymer, such as the commercially available Pluronic.RTM. polymers, or a poly(ethylene glycol)methyl ether polymer. The polymers may be used for drug and gene delivery, protein separation, as structural supplements, and more.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {5}
}

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Works referenced in this record:

Synthesis of Controlled Structure Water-Soluble Diblock Copolymers via Oxyanionic Polymerization
journal, March 1999


Food Authenticity
journal, May 2001


Structure of pH-Dependent Block Copolymer Micelles:  Charge and Ionic Strength Dependence
journal, October 2002