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Title: Accommodating subject and instrument variations in spectroscopic determinations

Abstract

A method and apparatus for measuring a biological attribute, such as the concentration of an analyte, particularly a blood analyte in tissue such as glucose. The method utilizes spectrographic techniques in conjunction with an improved instrument-tailored or subject-tailored calibration model. In a calibration phase, calibration model data is modified to reduce or eliminate instrument-specific attributes, resulting in a calibration data set modeling intra-instrument or intra-subject variation. In a prediction phase, the prediction process is tailored for each target instrument separately using a minimal number of spectral measurements from each instrument or subject.

Inventors:
 [1];  [2];  [1]
  1. Albuquerque, NM
  2. Corrales, NM
Issue Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
908262
Patent Number(s):
7098037
Application Number:
10/222,721
Assignee:
InLight Solutions, Inc. (Albuquerque, NM)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Haas, Michael J, Rowe, Robert K, and Thomas, Edward V. Accommodating subject and instrument variations in spectroscopic determinations. United States: N. p., 2006. Web.
Haas, Michael J, Rowe, Robert K, & Thomas, Edward V. Accommodating subject and instrument variations in spectroscopic determinations. United States.
Haas, Michael J, Rowe, Robert K, and Thomas, Edward V. Tue . "Accommodating subject and instrument variations in spectroscopic determinations". United States. https://www.osti.gov/servlets/purl/908262.
@article{osti_908262,
title = {Accommodating subject and instrument variations in spectroscopic determinations},
author = {Haas, Michael J and Rowe, Robert K and Thomas, Edward V},
abstractNote = {A method and apparatus for measuring a biological attribute, such as the concentration of an analyte, particularly a blood analyte in tissue such as glucose. The method utilizes spectrographic techniques in conjunction with an improved instrument-tailored or subject-tailored calibration model. In a calibration phase, calibration model data is modified to reduce or eliminate instrument-specific attributes, resulting in a calibration data set modeling intra-instrument or intra-subject variation. In a prediction phase, the prediction process is tailored for each target instrument separately using a minimal number of spectral measurements from each instrument or subject.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {8}
}

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Works referenced in this record:

Improvement of multivariate calibration through instrument standardization
journal, March 1992


Post-Prandial Blood Glucose Determination by Quantitative Mid-Infrared Spectroscopy
journal, June 1992


Fundamentals of Calibration Transfer through Procrustes Analysis
journal, October 1999


On-line monitoring of the delivery of the hemodialysis prescription
journal, January 1995


Noninvasive Blood Glucose Sensors Based on Near-Infrared Spectroscopy
journal, June 1994


Noninvasive Glucose Monitoring in Diabetic Patients: A Preliminary Evaluation
journal, September 1992


Glucose measurement in patients with diabetes mellitus with dermal interstitial fluid
journal, October 1997


Dermal Interstitial Glucose as an Indicator of Ambient Glycemia
journal, September 1997


Reagentless Near-Infrared Determination of Glucose in Whole Blood Using Multivariate Calibration
journal, October 1992


Noninvasive Blood Glucose Assay by Near-Infrared Diffuse Reflectance Spectroscopy of the Human Inner Lip
journal, July 1993


Non-Invasive Monitoring of Metabolites Using Near Infrared Spectroscopy: State of the Art
journal, October 1996


Additive Background Correction in Multivariate Instrument Standardization
journal, July 1995


Temperatures of skin, subcutaneous tissue, muscle and core in resting men in cold, comfortable and hot conditions
journal, January 1992


Standardization of Fiber-Optic Probes for Near-Infrared Multivariate Calibrations
journal, June 1998


The Measurement of Dialysis Access Recirculation
journal, October 1993


Theory and validation of access flow measurement by dilution technique during hemodialysis
journal, July 1995


On-Line Urea Monitoring: A Further Step towards Adequate Dialysis Prescription and Delivery
journal, September 1995


Improvement of PLS model transferability by robust wavelength selection
journal, July 1998


Spectroscopic and Clinical Aspects of Noninvasive Glucose Measurements
journal, February 1999


Optical Matching of near Infrared Reflectance Monochromator Instruments for the Analysis of Ground and Whole Wheat
journal, June 1999


Infrared Diffuse Reflectance Accessory for Local Analysis on Bulky Samples
journal, January 1988


Noninvasive Prediction of Glucose by Near-Infrared Diffuse Reflectance Spectroscopy
journal, September 1999


Comparison of Two Different Approaches toward Model Transferability in NIR Spectroscopy
journal, January 1998


Calibration Transfer and Measurement Stability of Near-Infrared Spectrometers
journal, May 1992


Effects of Dose of Dialysis on Morbidity and Mortality
journal, May 1994


Hybrid Calibration Models: An Alternative to Calibration Transfer
journal, April 1998


Application of Near-Infrared Spectroscopy for Non-Invasive Determination of Blood/Tissue Glucose Using Neural Networks
journal, January 1995


An evaluation of orthogonal signal correction applied to calibration transfer of near infrared spectra
journal, December 1998


A Disposable Urea Sensor for Continuous Monitoring of Hemodialysis Efficiency
journal, January 1993