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Title: Accommodating subject and instrument variations in spectroscopic determinations

Abstract

A method and apparatus for measuring a biological attribute, such as the concentration of an analyte, particularly a blood analyte in tissue such as glucose. The method utilizes spectrographic techniques in conjunction with an improved instrument-tailored or subject-tailored calibration model. In a calibration phase, calibration model data is modified to reduce or eliminate instrument-specific attributes, resulting in a calibration data set modeling intra-instrument or intra-subject variation. In a prediction phase, the prediction process is tailored for each target instrument separately using a minimal number of spectral measurements from each instrument or subject.

Inventors:
 [1];  [2];  [1]
  1. Albuquerque, NM
  2. Corrales, NM
Issue Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
908262
Patent Number(s):
7098037
Application Number:
10/222,721
Assignee:
InLight Solutions, Inc. (Albuquerque, NM)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Haas, Michael J, Rowe, Robert K, and Thomas, Edward V. Accommodating subject and instrument variations in spectroscopic determinations. United States: N. p., 2006. Web.
Haas, Michael J, Rowe, Robert K, & Thomas, Edward V. Accommodating subject and instrument variations in spectroscopic determinations. United States.
Haas, Michael J, Rowe, Robert K, and Thomas, Edward V. Tue . "Accommodating subject and instrument variations in spectroscopic determinations". United States. https://www.osti.gov/servlets/purl/908262.
@article{osti_908262,
title = {Accommodating subject and instrument variations in spectroscopic determinations},
author = {Haas, Michael J and Rowe, Robert K and Thomas, Edward V},
abstractNote = {A method and apparatus for measuring a biological attribute, such as the concentration of an analyte, particularly a blood analyte in tissue such as glucose. The method utilizes spectrographic techniques in conjunction with an improved instrument-tailored or subject-tailored calibration model. In a calibration phase, calibration model data is modified to reduce or eliminate instrument-specific attributes, resulting in a calibration data set modeling intra-instrument or intra-subject variation. In a prediction phase, the prediction process is tailored for each target instrument separately using a minimal number of spectral measurements from each instrument or subject.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {8}
}

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