Method to fabricate hollow microneedle arrays

Kravitz, Stanley H; Ingersoll, David; Schmidt, Carrie; Flemming, Jeb

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Title: Method to fabricate hollow microneedle arrays

Abstract

An inexpensive and rapid method for fabricating arrays of hollow microneedles uses a photoetchable glass. Furthermore, the glass hollow microneedle array can be used to form a negative mold for replicating microneedles in biocompatible polymers or metals. These microneedle arrays can be used to extract fluids from plants or animals. Glucose transport through these hollow microneedles arrays has been found to be orders of magnitude more rapid than natural diffusion.

Inventors:

Kravitz, Stanley H ^[1]; Ingersoll, David ^[2]; Schmidt, Carrie ^[3]; Flemming, Jeb ^[2]

Placitas, NM
Albuquerque, NM
Los Lunas, NM

Issue Date:: 2006-11-07

Research Org.:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 908048

Patent Number(s):: 7132054

Application Number:: 10/936,360

Assignee:: Sandia Corporation (Albuquerque, NM)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY

B - PERFORMING OPERATIONS B81 - MICROSTRUCTURAL TECHNOLOGY B81B - MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
A61M2037/0053 - {Methods for producing microneedles}
A61M37/0015 - {by using microneedles}

B - PERFORMING OPERATIONS B81 - MICROSTRUCTURAL TECHNOLOGY B81B - MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
B81B2201/055 - Microneedles

B - PERFORMING OPERATIONS B81 - MICROSTRUCTURAL TECHNOLOGY B81C - PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
B81C1/00111 - {Tips, pillars, i.e. raised structures

C - CHEMISTRY C03 - GLASS C03C - CHEMICAL COMPOSITION OF GLASSES, GLAZES, OR VITREOUS ENAMELS
C03C15/00 - Surface treatment of glass, not in the form of fibres or filaments, by etching
C03C23/002 - {by ultra-violet light}
C03C23/007 - {by thermal treatment}

C - CHEMISTRY C23 - COATING METALLIC MATERIAL C23F - NON-MECHANICAL REMOVAL OF METALLIC MATERIAL FROM SURFACE
C23F1/00 - Etching metallic material by chemical means

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DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Kravitz, Stanley H, Ingersoll, David, Schmidt, Carrie, and Flemming, Jeb. Method to fabricate hollow microneedle arrays.  United States: N. p., 2006. 
        Web.

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                    Kravitz, Stanley H, Ingersoll, David, Schmidt, Carrie, & Flemming, Jeb. Method to fabricate hollow microneedle arrays.  United States.

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                    Kravitz, Stanley H, Ingersoll, David, Schmidt, Carrie, and Flemming, Jeb. Tue .  
        "Method to fabricate hollow microneedle arrays".  United States.  https://www.osti.gov/servlets/purl/908048.

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@article{osti_908048,

  title        = {Method to fabricate hollow microneedle arrays},

  author       = {Kravitz, Stanley H and Ingersoll, David and Schmidt, Carrie and Flemming, Jeb},

  abstractNote = {An inexpensive and rapid method for fabricating arrays of hollow microneedles uses a photoetchable glass. Furthermore, the glass hollow microneedle array can be used to form a negative mold for replicating microneedles in biocompatible polymers or metals. These microneedle arrays can be used to extract fluids from plants or animals. Glucose transport through these hollow microneedles arrays has been found to be orders of magnitude more rapid than natural diffusion.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2006},

  month        = {11}

}

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Works referenced in this record:

Microneedles for transdermal drug delivery
journal, March 2004

Prausnitz, Mark R.
Advanced Drug Delivery Reviews, Vol. 56, Issue 5, p. 581-587
https://doi.org/10.1016/j.addr.2003.10.023

Micromachined needles for microbiological sample and drug delivery system
conference, January 2003

Zhang, P.; Jullien, G. A.
Proceedings International Conference on MEMS, NANO and Smart Systems
https://doi.org/10.1109/ICMENS.2003.1222000

Silicon micromachined hollow microneedles for transdermal liquid transport
journal, December 2003

Gardeniers, H. J. G. E.; Luttge, R.; Berenschot, E. J. W.
Journal of Microelectromechanical Systems, Vol. 12, Issue 6, p. 855-862
https://doi.org/10.1109/JMEMS.2003.820293

Fabrication of true 3D microstructures in glass/ceramic materials by pulsed UV laser volumetric exposure techniques
conference, July 1999

Fuqua, Peter D.; Janson, Siegfried W.; Hansen, William W.
Optoelectronics '99 - Integrated Optoelectronic Devices, SPIE Proceedings
https://doi.org/10.1117/12.352714

Fabrication and simulation of novel crown-shaped microneedle array
conference, February 2005

Khumpuang, Sommawan; Sugiyama, Susumu
Smart Materials, Nano-, and Micro-Smart Systems, SPIE Proceedings
https://doi.org/10.1117/12.582360

Fabrication technologies for microsystems utilizing photoetchable glass
journal, January 1996

Dietrich, T. R.; Ehrfeld, W.; Lacher, M.
Microelectronic Engineering, Vol. 30, Issue 1-4
https://doi.org/10.1016/0167-9317(95)00295-2

3D microstructuring inside photosensitive glass by use of a femtosecond laser for lab-on-chip applications
conference, July 2003

Cheng, Ya; Sugioka, Koji; Masuda, Masashi
High-Power Lasers and Applications, SPIE Proceedings
https://doi.org/10.1117/12.479539

Novel low cost fabrication of microneedle arrays for drug delivery applications
conference, November 2002

Tan, Pei Ying J.; Xu, Yuan; Chew, Yong T.
SPIE's International Symposium on Smart Materials, Nano-, and Micro- Smart Systems, SPIE Proceedings
https://doi.org/10.1117/12.469435

Side-opened out-of-plane microneedles for microfluidic transdermal liquid transfer
journal, June 2003

Griss, P.; Stemme, G.
Journal of Microelectromechanical Systems, Vol. 12, Issue 3
https://doi.org/10.1109/JMEMS.2003.809959

Photoetchable glass for microsystems: tips for atomic force microscopy
journal, December 1993

Dietrich, T. R.; Abraham, M.; Diebel, J.
Journal of Micromechanics and Microengineering, Vol. 3, Issue 4
https://doi.org/10.1088/0960-1317/3/4/004

Direct-write UV-laser microfabrication of 3D structures in lithium-aluminosilicate glass
conference, May 1997

Hansen, William W.; Janson, Siegfried W.; Helvajian, Henry
Photonics West '97, SPIE Proceedings
https://doi.org/10.1117/12.273716

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Similar Records

Title: Method to fabricate hollow microneedle arrays

Abstract

Citation Formats

Microneedles for transdermal drug delivery journal, March 2004

Micromachined needles for microbiological sample and drug delivery system conference, January 2003

Silicon micromachined hollow microneedles for transdermal liquid transport journal, December 2003

Fabrication of true 3D microstructures in glass/ceramic materials by pulsed UV laser volumetric exposure techniques conference, July 1999

Fabrication and simulation of novel crown-shaped microneedle array conference, February 2005

Fabrication technologies for microsystems utilizing photoetchable glass journal, January 1996

3D microstructuring inside photosensitive glass by use of a femtosecond laser for lab-on-chip applications conference, July 2003

Novel low cost fabrication of microneedle arrays for drug delivery applications conference, November 2002

Side-opened out-of-plane microneedles for microfluidic transdermal liquid transfer journal, June 2003

Photoetchable glass for microsystems: tips for atomic force microscopy journal, December 1993

Direct-write UV-laser microfabrication of 3D structures in lithium-aluminosilicate glass conference, May 1997

Microneedles for transdermal drug delivery
journal, March 2004

Micromachined needles for microbiological sample and drug delivery system
conference, January 2003

Silicon micromachined hollow microneedles for transdermal liquid transport
journal, December 2003

Fabrication of true 3D microstructures in glass/ceramic materials by pulsed UV laser volumetric exposure techniques
conference, July 1999

Fabrication and simulation of novel crown-shaped microneedle array
conference, February 2005

Fabrication technologies for microsystems utilizing photoetchable glass
journal, January 1996

3D microstructuring inside photosensitive glass by use of a femtosecond laser for lab-on-chip applications
conference, July 2003

Novel low cost fabrication of microneedle arrays for drug delivery applications
conference, November 2002

Side-opened out-of-plane microneedles for microfluidic transdermal liquid transfer
journal, June 2003

Photoetchable glass for microsystems: tips for atomic force microscopy
journal, December 1993

Direct-write UV-laser microfabrication of 3D structures in lithium-aluminosilicate glass
conference, May 1997