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Title: Device for two-dimensional gas-phase separation and characterization of ion mixtures

Abstract

The present invention relates to a device for separation and characterization of gas-phase ions. The device incorporates an ion source, a field asymmetric waveform ion mobility spectrometry (FAIMS) analyzer, an ion mobility spectrometry (IMS) drift tube, and an ion detector. In one aspect of the invention, FAIMS operating voltages are electrically floated on top of the IMS drift voltage. In the other aspect, the FAIMS/IMS interface is implemented employing an electrodynamic ion funnel, including in particular an hourglass ion funnel. The present invention improves the efficiency (peak capacity) and sensitivity of gas-phase separations; the online FAIMS/IMS coupling creates a fundamentally novel two-dimensional gas-phase separation technology with high peak capacity, specificity, and exceptional throughput.

Inventors:
 [1];  [1];  [1]
  1. Richland, WA
Issue Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
907978
Patent Number(s):
7148474
Application Number:
11/103,984
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Tang, Keqi, Shvartsburg, Alexandre A, and Smith, Richard D. Device for two-dimensional gas-phase separation and characterization of ion mixtures. United States: N. p., 2006. Web.
Tang, Keqi, Shvartsburg, Alexandre A, & Smith, Richard D. Device for two-dimensional gas-phase separation and characterization of ion mixtures. United States.
Tang, Keqi, Shvartsburg, Alexandre A, and Smith, Richard D. Tue . "Device for two-dimensional gas-phase separation and characterization of ion mixtures". United States. https://www.osti.gov/servlets/purl/907978.
@article{osti_907978,
title = {Device for two-dimensional gas-phase separation and characterization of ion mixtures},
author = {Tang, Keqi and Shvartsburg, Alexandre A and Smith, Richard D},
abstractNote = {The present invention relates to a device for separation and characterization of gas-phase ions. The device incorporates an ion source, a field asymmetric waveform ion mobility spectrometry (FAIMS) analyzer, an ion mobility spectrometry (IMS) drift tube, and an ion detector. In one aspect of the invention, FAIMS operating voltages are electrically floated on top of the IMS drift voltage. In the other aspect, the FAIMS/IMS interface is implemented employing an electrodynamic ion funnel, including in particular an hourglass ion funnel. The present invention improves the efficiency (peak capacity) and sensitivity of gas-phase separations; the online FAIMS/IMS coupling creates a fundamentally novel two-dimensional gas-phase separation technology with high peak capacity, specificity, and exceptional throughput.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {12}
}

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Works referenced in this record:

H/D Exchange Levels of Shape-Resolved Cytochrome c Conformers in the Gas Phase
journal, April 1997


Hydrogen/deuterium exchange electrospray ionization mass spectrometry: a method for probing protein conformational changes in solution
journal, July 1993


High-field asymmetric waveform ion mobility spectrometry: A new tool for mass spectrometry
journal, November 2004