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Title: Methanobactin: a copper binding compound having antibiotic and antioxidant activity isolated from methanotrophic bacteria

Abstract

A means and method for treating bacterial infection, providing antioxidant activity, and chelating copper using a copper binding compound produced by methanotrophic bacteria is described. The compound, known as methanobactin, is the first of a new class of antibiotics having gram-positive activity. Methanobactin has been sequenced, and its structural formula determined.

Inventors:
 [1];  [2];  [3];  [4];  [3];  [3]
  1. Ames, IA
  2. Harbor Beach, MI
  3. Lawrence, KS
  4. St. Paul, MN
Issue Date:
Research Org.:
Iowa State Univ., Ames, IA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
907754
Patent Number(s):
7199099
Application Number:
10/741,831
Assignee:
The University of Kansas (Lawrence, KS); Iowa State University Research Foundation, Inc. (Ames, IA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
FG02-96ER20237
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

DiSpirito, Alan A, Zahn, James A, Graham, David W, Kim, Hyung J, Alterman, Michail, and Larive, Cynthia. Methanobactin: a copper binding compound having antibiotic and antioxidant activity isolated from methanotrophic bacteria. United States: N. p., 2007. Web.
DiSpirito, Alan A, Zahn, James A, Graham, David W, Kim, Hyung J, Alterman, Michail, & Larive, Cynthia. Methanobactin: a copper binding compound having antibiotic and antioxidant activity isolated from methanotrophic bacteria. United States.
DiSpirito, Alan A, Zahn, James A, Graham, David W, Kim, Hyung J, Alterman, Michail, and Larive, Cynthia. Tue . "Methanobactin: a copper binding compound having antibiotic and antioxidant activity isolated from methanotrophic bacteria". United States. https://www.osti.gov/servlets/purl/907754.
@article{osti_907754,
title = {Methanobactin: a copper binding compound having antibiotic and antioxidant activity isolated from methanotrophic bacteria},
author = {DiSpirito, Alan A and Zahn, James A and Graham, David W and Kim, Hyung J and Alterman, Michail and Larive, Cynthia},
abstractNote = {A means and method for treating bacterial infection, providing antioxidant activity, and chelating copper using a copper binding compound produced by methanotrophic bacteria is described. The compound, known as methanobactin, is the first of a new class of antibiotics having gram-positive activity. Methanobactin has been sequenced, and its structural formula determined.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {4}
}

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Works referenced in this record:

Expression of soluble methane monooxygenase genes
journal, November 2002


Tissue injury by reactive oxygen species and the protective effects of flavonoids
journal, May 1998


Particulate methane monooxygenase from Methylosinus trichosporium is a copper-containing enzyme
journal, July 2002


Isolation of Copper Biochelates fromMethylosinus trichosporium OB3b and Soluble Methane Monooxygenase Mutants
journal, March 1998


Oxidativer Stress, altersabhängige Zellschädigungen und antioxidative Mechanismen
journal, April 2002


Copper-Binding Compounds from Methylosinus trichosporium OB3b
journal, July 1998


Membrane-associated methane monooxygenase from Methylococcus capsulatus (Bath).
journal, February 1996