Sample Desorption/Onization From Mesoporous Silica
Abstract
Mesoporous silica is shown to be a sample holder for laser desorption/ionization of mass spectrometry. Supported mesoporous silica was prepared by coating an ethanolic silicate solution having a removable surfactant onto a substrate to produce a self-assembled, ordered, nanocomposite silica thin film. The surfactant was chosen to provide a desired pore size between about 1 nanometer diameter and 50 nanometers diameter. Removal of the surfactant resulted in a mesoporous silica thin film on the substrate. Samples having a molecular weight below 1000, such as C.sub.60 and tryptophan, were adsorbed onto and into the mesoporous silica thin film sample holder and analyzed using laser desorption/ionization mass spectrometry.
- Inventors:
-
- Los Alamos, NM
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- OSTI Identifier:
- 880504
- Patent Number(s):
- 6958480
- Application Number:
- 10/877690
- Assignee:
- The Regents of the University of California (Los Alamos, NM)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Iyer, Srinivas, and Dattelbaum, Andrew M. Sample Desorption/Onization From Mesoporous Silica. United States: N. p., 2005.
Web.
Iyer, Srinivas, & Dattelbaum, Andrew M. Sample Desorption/Onization From Mesoporous Silica. United States.
Iyer, Srinivas, and Dattelbaum, Andrew M. Tue .
"Sample Desorption/Onization From Mesoporous Silica". United States. https://www.osti.gov/servlets/purl/880504.
@article{osti_880504,
title = {Sample Desorption/Onization From Mesoporous Silica},
author = {Iyer, Srinivas and Dattelbaum, Andrew M},
abstractNote = {Mesoporous silica is shown to be a sample holder for laser desorption/ionization of mass spectrometry. Supported mesoporous silica was prepared by coating an ethanolic silicate solution having a removable surfactant onto a substrate to produce a self-assembled, ordered, nanocomposite silica thin film. The surfactant was chosen to provide a desired pore size between about 1 nanometer diameter and 50 nanometers diameter. Removal of the surfactant resulted in a mesoporous silica thin film on the substrate. Samples having a molecular weight below 1000, such as C.sub.60 and tryptophan, were adsorbed onto and into the mesoporous silica thin film sample holder and analyzed using laser desorption/ionization mass spectrometry.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 25 00:00:00 EDT 2005},
month = {Tue Oct 25 00:00:00 EDT 2005}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Desorption/ionization on silicon (DIOS) mass spectrometry: background and applications
journal, March 2003
- Lewis, Warren G.; Shen, Zhouxin; Finn, M. G.
- International Journal of Mass Spectrometry, Vol. 226, Issue 1
Novel method for matrix-assisted laser mass spectrometry of proteins
journal, March 1991
- Zhao, Shankai.; Somayajula, Kasi V.; Sharkey, Andrew G.
- Analytical Chemistry, Vol. 63, Issue 5
Desorption−Ionization Mass Spectrometry Using Deposited Nanostructured Silicon Films
journal, March 2001
- Cuiffi, Joseph D.; Hayes, Daniel J.; Fonash, Stephen J.
- Analytical Chemistry, Vol. 73, Issue 6
Desorption–ionization mass spectrometry on porous silicon
journal, May 1999
- Wei, Jing; Buriak, Jillian M.; Siuzdak, Gary
- Nature, Vol. 399, Issue 6733
Laser desorption substrate effects
journal, May 1997
- Zhan, Q.; Wright, S.; Zenobi, R.
- Journal of the American Society for Mass Spectrometry, Vol. 8, Issue 5
Californium-252 plasma desorption mass spectroscopy
journal, March 1976
- Macfarlane, R.; Torgerson, D.
- Science, Vol. 191, Issue 4230
Laser desorption-mass spectrometry of polar nonvolatile bio-organic molecules
journal, June 1978
- Posthumus, M. A.; Kistemaker, P. G.; Meuzelaar, H. L. C.
- Analytical Chemistry, Vol. 50, Issue 7
Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons
journal, October 1988
- Karas, Michael.; Hillenkamp, Franz.
- Analytical Chemistry, Vol. 60, Issue 20
Studies of silicon-nitride (Si3N4) using laser ablation mass spectrometry
journal, March 1996
- Wang, S. L.; Ledingham, K. W. D.; Jia, W. J.
- Applied Surface Science, Vol. 93, Issue 3
Scalable Synthesis of a New Class of Polymer Microrods by a Liquid-Liquid Dispersion Technique
journal, September 2004
- Alargova, R. G.; Bhatt, K. H.; Paunov, V. N.
- Advanced Materials, Vol. 16, Issue 18
Some new field desorption techniques
journal, March 1970
- Beckey, H. D.; Heindrichs, A.; Winkler, H. U.
- International Journal of Mass Spectrometry and Ion Physics, Vol. 3, Issue 6
Detection of biomolecules on surfaces using ion-beam-induced desorption and multiphoton resonance ionization
journal, September 1991
- Hrubowchak, D. M.; Ervin, M. H.; Wood, M. C.
- Analytical Chemistry, Vol. 63, Issue 18