skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Sample Desorption/Onization From Mesoporous Silica

Abstract

Mesoporous silica is shown to be a sample holder for laser desorption/ionization of mass spectrometry. Supported mesoporous silica was prepared by coating an ethanolic silicate solution having a removable surfactant onto a substrate to produce a self-assembled, ordered, nanocomposite silica thin film. The surfactant was chosen to provide a desired pore size between about 1 nanometer diameter and 50 nanometers diameter. Removal of the surfactant resulted in a mesoporous silica thin film on the substrate. Samples having a molecular weight below 1000, such as C.sub.60 and tryptophan, were adsorbed onto and into the mesoporous silica thin film sample holder and analyzed using laser desorption/ionization mass spectrometry.

Inventors:
 [1];  [1]
  1. Los Alamos, NM
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
OSTI Identifier:
880504
Patent Number(s):
6958480
Application Number:
10/877690
Assignee:
The Regents of the University of California (Los Alamos, NM)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Iyer, Srinivas, and Dattelbaum, Andrew M. Sample Desorption/Onization From Mesoporous Silica. United States: N. p., 2005. Web.
Iyer, Srinivas, & Dattelbaum, Andrew M. Sample Desorption/Onization From Mesoporous Silica. United States.
Iyer, Srinivas, and Dattelbaum, Andrew M. Tue . "Sample Desorption/Onization From Mesoporous Silica". United States. https://www.osti.gov/servlets/purl/880504.
@article{osti_880504,
title = {Sample Desorption/Onization From Mesoporous Silica},
author = {Iyer, Srinivas and Dattelbaum, Andrew M},
abstractNote = {Mesoporous silica is shown to be a sample holder for laser desorption/ionization of mass spectrometry. Supported mesoporous silica was prepared by coating an ethanolic silicate solution having a removable surfactant onto a substrate to produce a self-assembled, ordered, nanocomposite silica thin film. The surfactant was chosen to provide a desired pore size between about 1 nanometer diameter and 50 nanometers diameter. Removal of the surfactant resulted in a mesoporous silica thin film on the substrate. Samples having a molecular weight below 1000, such as C.sub.60 and tryptophan, were adsorbed onto and into the mesoporous silica thin film sample holder and analyzed using laser desorption/ionization mass spectrometry.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {10}
}

Patent:

Save / Share:

Works referenced in this record:

Desorption/ionization on silicon (DIOS) mass spectrometry: background and applications
journal, March 2003


Novel method for matrix-assisted laser mass spectrometry of proteins
journal, March 1991


Desorption−Ionization Mass Spectrometry Using Deposited Nanostructured Silicon Films
journal, March 2001


Desorption–ionization mass spectrometry on porous silicon
journal, May 1999


Laser desorption substrate effects
journal, May 1997


Californium-252 plasma desorption mass spectroscopy
journal, March 1976


Laser desorption-mass spectrometry of polar nonvolatile bio-organic molecules
journal, June 1978


Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons
journal, October 1988


Studies of silicon-nitride (Si3N4) using laser ablation mass spectrometry
journal, March 1996


Scalable Synthesis of a New Class of Polymer Microrods by a Liquid-Liquid Dispersion Technique
journal, September 2004


Some new field desorption techniques
journal, March 1970


Detection of biomolecules on surfaces using ion-beam-induced desorption and multiphoton resonance ionization
journal, September 1991