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Title: Determination Of Ph Including Hemoglobin Correction

Abstract

Methods and apparatuses of determining the pH of a sample. A method can comprise determining an infrared spectrum of the sample, and determining the hemoglobin concentration of the sample. The hemoglobin concentration and the infrared spectrum can then be used to determine the pH of the sample. In some embodiments, the hemoglobin concentration can be used to select an model relating infrared spectra to pH that is applicable at the determined hemoglobin concentration. In other embodiments, a model relating hemoglobin concentration and infrared spectra to pH can be used. An apparatus according to the present invention can comprise an illumination system, adapted to supply radiation to a sample; a collection system, adapted to collect radiation expressed from the sample responsive to the incident radiation; and an analysis system, adapted to relate information about the incident radiation, the expressed radiation, and the hemoglobin concentration of the sample to pH.

Inventors:
 [1];  [1];  [1];  [1];  [2];  [3];  [4]
  1. Albuquerque, NM
  2. Cedar Crest, NM
  3. Franklin, TN
  4. Madison, WI
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
OSTI Identifier:
880370
Patent Number(s):
6944487
Application Number:
10/786662
Assignee:
InLight Solutions, Inc. (Albuquerque, NM)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Maynard, John D, Hendee, Shonn P, Rohrscheib, Mark R, Nunez, David, Alam, M Kathleen, Franke, James E, and Kemeny, Gabor J. Determination Of Ph Including Hemoglobin Correction. United States: N. p., 2005. Web.
Maynard, John D, Hendee, Shonn P, Rohrscheib, Mark R, Nunez, David, Alam, M Kathleen, Franke, James E, & Kemeny, Gabor J. Determination Of Ph Including Hemoglobin Correction. United States.
Maynard, John D, Hendee, Shonn P, Rohrscheib, Mark R, Nunez, David, Alam, M Kathleen, Franke, James E, and Kemeny, Gabor J. Tue . "Determination Of Ph Including Hemoglobin Correction". United States. https://www.osti.gov/servlets/purl/880370.
@article{osti_880370,
title = {Determination Of Ph Including Hemoglobin Correction},
author = {Maynard, John D and Hendee, Shonn P and Rohrscheib, Mark R and Nunez, David and Alam, M Kathleen and Franke, James E and Kemeny, Gabor J},
abstractNote = {Methods and apparatuses of determining the pH of a sample. A method can comprise determining an infrared spectrum of the sample, and determining the hemoglobin concentration of the sample. The hemoglobin concentration and the infrared spectrum can then be used to determine the pH of the sample. In some embodiments, the hemoglobin concentration can be used to select an model relating infrared spectra to pH that is applicable at the determined hemoglobin concentration. In other embodiments, a model relating hemoglobin concentration and infrared spectra to pH can be used. An apparatus according to the present invention can comprise an illumination system, adapted to supply radiation to a sample; a collection system, adapted to collect radiation expressed from the sample responsive to the incident radiation; and an analysis system, adapted to relate information about the incident radiation, the expressed radiation, and the hemoglobin concentration of the sample to pH.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {9}
}

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Works referenced in this record:

Measurement of pH in Whole Blood by Near-Infrared Spectroscopy
journal, March 1999


Characterization of pH Variation in Lysed Blood by Near-Infrared Spectroscopy
journal, March 1998


Hemoglobin Correction for Near-Infrared pH Determination in Lysed Blood Solutions
journal, September 2003


Spectrophotometry of Human Hemoglobin in the near Infrared Region from 1000 to 2500 nm
journal, March 1994


Partial Least-Squares Modeling of Near-Infrared Reflectance Data for Noninvasive in Vivo Determination of Deep-Tissue pH
journal, March 1998