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Title: Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides

Abstract

A method of inhibiting at least one molecular process in a sample, comprising administering to the sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I): wherein A is an organic moiety, n is at least 1, and each X is independently selected from the group consisting of --NRCOCONu, --NHCOCR.sub.2 CR.sub.2 CONu, --NHCOCR.dbd.CRCONu, and --NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile, or a salt of the compound.

Inventors:
 [1];  [1];  [2];  [1]
  1. (Germantown, MD)
  2. (Montgomery Village, MD)
Issue Date:
Research Org.:
Fidelity Systems, Inc. (Gaithersburg, MD)
OSTI Identifier:
880175
Patent Number(s):
6548251
Application Number:
10/655804
Assignee:
Fidelity Systems, Inc. (Gaithersburg, MD) CHO
DOE Contract Number:  
FG02-98ER82577
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Kozyavkin, Sergei A., Malykh, Andrei G., Polouchine, Nikolai N., and Slesarev, Alexei I. Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides. United States: N. p., 2003. Web.
Kozyavkin, Sergei A., Malykh, Andrei G., Polouchine, Nikolai N., & Slesarev, Alexei I. Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides. United States.
Kozyavkin, Sergei A., Malykh, Andrei G., Polouchine, Nikolai N., and Slesarev, Alexei I. Tue . "Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides". United States. https://www.osti.gov/servlets/purl/880175.
@article{osti_880175,
title = {Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides},
author = {Kozyavkin, Sergei A. and Malykh, Andrei G. and Polouchine, Nikolai N. and Slesarev, Alexei I.},
abstractNote = {A method of inhibiting at least one molecular process in a sample, comprising administering to the sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I): wherein A is an organic moiety, n is at least 1, and each X is independently selected from the group consisting of --NRCOCONu, --NHCOCR.sub.2 CR.sub.2 CONu, --NHCOCR.dbd.CRCONu, and --NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile, or a salt of the compound.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {4}
}

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