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Title: Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides

Abstract

A method of inhibiting at least one molecular process in a sample, comprising administering to the sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I): wherein A is an organic moiety, n is at least 1, and each X is independently selected from the group consisting of --NRCOCONu, --NHCOCR.sub.2 CR.sub.2 CONu, --NHCOCR.dbd.CRCONu, and --NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile, or a salt of the compound.

Inventors:
 [1];  [1];  [2];  [1]
  1. Germantown, MD
  2. Montgomery Village, MD
Issue Date:
Research Org.:
Fidelity Systems, Inc. (Gaithersburg, MD)
OSTI Identifier:
880175
Patent Number(s):
6548251
Application Number:
10/655804
Assignee:
Fidelity Systems, Inc. (Gaithersburg, MD)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
FG02-98ER82577
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Kozyavkin, Sergei A, Malykh, Andrei G, Polouchine, Nikolai N, and Slesarev, Alexei I. Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides. United States: N. p., 2003. Web.
Kozyavkin, Sergei A, Malykh, Andrei G, Polouchine, Nikolai N, & Slesarev, Alexei I. Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides. United States.
Kozyavkin, Sergei A, Malykh, Andrei G, Polouchine, Nikolai N, and Slesarev, Alexei I. Tue . "Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides". United States. https://www.osti.gov/servlets/purl/880175.
@article{osti_880175,
title = {Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides},
author = {Kozyavkin, Sergei A and Malykh, Andrei G and Polouchine, Nikolai N and Slesarev, Alexei I},
abstractNote = {A method of inhibiting at least one molecular process in a sample, comprising administering to the sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I): wherein A is an organic moiety, n is at least 1, and each X is independently selected from the group consisting of --NRCOCONu, --NHCOCR.sub.2 CR.sub.2 CONu, --NHCOCR.dbd.CRCONu, and --NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile, or a salt of the compound.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {4}
}

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Works referenced in this record:

Drug Leads from Combinatorial Phosphodiester Libraries
journal, October 1995


Synthesis of functionally tethered oligodeoxynucleotides by the convertible nucleoside approach
journal, November 1990


Synthesis of N-substituted hydroxyprolinol phosphoramidites for the preparation of combinatorial libraries
journal, December 1994


Oxalyl-CPG: a labile support for synthesis of sensitive oligonucleotide derivatives
journal, January 1991


Synthesis and characterization of imidazoyl-linked synthons and 3'-conjugated thymidine derivatives
journal, August 1993


Synthesis of oligonucleotides containing 2′-azido- and 2′-amino-2′-deoxyuridine using phosphotriester chemistry
journal, May 1996


Engineering tethered DNA molecules by the convertible nucleoside approach
journal, January 1991


Synthesis of 2′–modified nucleotides and their incorporation into hammerhead ribozymes
journal, January 1995