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Title: Method And Apparatus For Detecting Chemical Binding

Abstract

The method for screening binding between a target binder and potential pharmaceutical chemicals involves sending a solution (preferably an aqueous solution) of the target binder through a conduit to a size exclusion filter, the target binder being too large to pass through the size exclusion filter, and then sending a solution of one or more potential pharmaceutical chemicals (preferably an aqueous solution) through the same conduit to the size exclusion filter after target binder has collected on the filter. The potential pharmaceutical chemicals are small enough to pass through the filter. Afterwards, x-rays are sent from an x-ray source to the size exclusion filter, and if the potential pharmaceutical chemicals form a complex with the target binder, the complex produces an x-ray fluorescence signal having an intensity that indicates that a complex has formed.

Inventors:
 [1];  [1];  [1];  [1]
  1. Los Alamos, NM
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
OSTI Identifier:
880120
Patent Number(s):
6858148
Application Number:
10/621825
Assignee:
The Regents of the University of California (Los Alamos, NM)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Warner, Benjamin P, Havrilla, George J, Miller, Thomasin C, and Wells, Cyndi A. Method And Apparatus For Detecting Chemical Binding. United States: N. p., 2005. Web.
Warner, Benjamin P, Havrilla, George J, Miller, Thomasin C, & Wells, Cyndi A. Method And Apparatus For Detecting Chemical Binding. United States.
Warner, Benjamin P, Havrilla, George J, Miller, Thomasin C, and Wells, Cyndi A. Tue . "Method And Apparatus For Detecting Chemical Binding". United States. https://www.osti.gov/servlets/purl/880120.
@article{osti_880120,
title = {Method And Apparatus For Detecting Chemical Binding},
author = {Warner, Benjamin P and Havrilla, George J and Miller, Thomasin C and Wells, Cyndi A},
abstractNote = {The method for screening binding between a target binder and potential pharmaceutical chemicals involves sending a solution (preferably an aqueous solution) of the target binder through a conduit to a size exclusion filter, the target binder being too large to pass through the size exclusion filter, and then sending a solution of one or more potential pharmaceutical chemicals (preferably an aqueous solution) through the same conduit to the size exclusion filter after target binder has collected on the filter. The potential pharmaceutical chemicals are small enough to pass through the filter. Afterwards, x-rays are sent from an x-ray source to the size exclusion filter, and if the potential pharmaceutical chemicals form a complex with the target binder, the complex produces an x-ray fluorescence signal having an intensity that indicates that a complex has formed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {2}
}

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Works referenced in this record:

On-line X-ray fluorescence detection for capillary electrophoresis separations
journal, January 1999


Element-sensitive X-ray detection for capillary electrophoresis
journal, March 1996


Element-Specific Detection in Capillary Electrophoresis Using X-ray Fluorescence Spectroscopy
journal, April 2000


Capillary Electrophoresis Micro X-ray Fluorescence:  A Tool for Benchtop Elemental Analysis
journal, May 2003