Two Dimensional Polymer That Generates Nitric Oxide.
Abstract
A polymeric composition that generates nitric oxide and a process for rendering the surface of a substrate nonthrombogenic by applying a coating of the polymeric composition to the substrate are disclosed. The composition comprises: (1) a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, and (ii) a crosslinking agent containing functional groups capable of reacting with the amino groups; and (2) a plurality of nitric oxide generating functional groups associated with the crosslinked chemical combination. Once exposed to a physiological environment, the coating generates nitric oxide thereby inhibiting platelet aggregation. In one embodiment, the nitric oxide generating functional groups are provided by a nitrated compound (e.g., nitrocellulose) imbedded in the polymeric composition. In another embodiment, the nitric oxide generating functional groups comprise N2O2- groups covalently bonded to amino groups on the polymer.
- Inventors:
-
- Utica, OH
- Lansing, MI
- Issue Date:
- Research Org.:
- Midwest Research Institute, Kansas City, MO (United States)
- OSTI Identifier:
- 879820
- Patent Number(s):
- 6951902
- Application Number:
- 10/222370
- Assignee:
- Michigan Biotechnology Institute (Lansing, MI)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- AC36-98GO10337
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
McDonald, William F, and Koren, Amy B. Two Dimensional Polymer That Generates Nitric Oxide.. United States: N. p., 2005.
Web.
McDonald, William F, & Koren, Amy B. Two Dimensional Polymer That Generates Nitric Oxide.. United States.
McDonald, William F, and Koren, Amy B. Tue .
"Two Dimensional Polymer That Generates Nitric Oxide.". United States. https://www.osti.gov/servlets/purl/879820.
@article{osti_879820,
title = {Two Dimensional Polymer That Generates Nitric Oxide.},
author = {McDonald, William F and Koren, Amy B},
abstractNote = {A polymeric composition that generates nitric oxide and a process for rendering the surface of a substrate nonthrombogenic by applying a coating of the polymeric composition to the substrate are disclosed. The composition comprises: (1) a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, and (ii) a crosslinking agent containing functional groups capable of reacting with the amino groups; and (2) a plurality of nitric oxide generating functional groups associated with the crosslinked chemical combination. Once exposed to a physiological environment, the coating generates nitric oxide thereby inhibiting platelet aggregation. In one embodiment, the nitric oxide generating functional groups are provided by a nitrated compound (e.g., nitrocellulose) imbedded in the polymeric composition. In another embodiment, the nitric oxide generating functional groups comprise N2O2- groups covalently bonded to amino groups on the polymer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {10}
}
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