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Title: Two Dimensional Polymer That Generates Nitric Oxide.

Abstract

A polymeric composition that generates nitric oxide and a process for rendering the surface of a substrate nonthrombogenic by applying a coating of the polymeric composition to the substrate are disclosed. The composition comprises: (1) a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, and (ii) a crosslinking agent containing functional groups capable of reacting with the amino groups; and (2) a plurality of nitric oxide generating functional groups associated with the crosslinked chemical combination. Once exposed to a physiological environment, the coating generates nitric oxide thereby inhibiting platelet aggregation. In one embodiment, the nitric oxide generating functional groups are provided by a nitrated compound (e.g., nitrocellulose) imbedded in the polymeric composition. In another embodiment, the nitric oxide generating functional groups comprise N2O2- groups covalently bonded to amino groups on the polymer.

Inventors:
 [1];  [2]
  1. Utica, OH
  2. Lansing, MI
Issue Date:
Research Org.:
Midwest Research Institute, Kansas City, MO (United States)
OSTI Identifier:
879820
Patent Number(s):
6951902
Application Number:
10/222370
Assignee:
Michigan Biotechnology Institute (Lansing, MI)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC36-98GO10337
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

McDonald, William F, and Koren, Amy B. Two Dimensional Polymer That Generates Nitric Oxide.. United States: N. p., 2005. Web.
McDonald, William F, & Koren, Amy B. Two Dimensional Polymer That Generates Nitric Oxide.. United States.
McDonald, William F, and Koren, Amy B. Tue . "Two Dimensional Polymer That Generates Nitric Oxide.". United States. https://www.osti.gov/servlets/purl/879820.
@article{osti_879820,
title = {Two Dimensional Polymer That Generates Nitric Oxide.},
author = {McDonald, William F and Koren, Amy B},
abstractNote = {A polymeric composition that generates nitric oxide and a process for rendering the surface of a substrate nonthrombogenic by applying a coating of the polymeric composition to the substrate are disclosed. The composition comprises: (1) a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, and (ii) a crosslinking agent containing functional groups capable of reacting with the amino groups; and (2) a plurality of nitric oxide generating functional groups associated with the crosslinked chemical combination. Once exposed to a physiological environment, the coating generates nitric oxide thereby inhibiting platelet aggregation. In one embodiment, the nitric oxide generating functional groups are provided by a nitrated compound (e.g., nitrocellulose) imbedded in the polymeric composition. In another embodiment, the nitric oxide generating functional groups comprise N2O2- groups covalently bonded to amino groups on the polymer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {10}
}

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Works referenced in this record:

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