Title: Method And Apparatus For High Resolution Ex-Situ Nmr Spectroscopy

Abstract

A method and apparatus for ex-situ nuclear magnetic resonance spectroscopy for use on samples outside the physical limits of the magnets in inhomogeneous static and radio-frequency fields. Chemical shift spectra can be resolved with the method using sequences of correlated, composite z-rotation pulses in the presence of spatially matched static and radio frequency field gradients producing nutation echoes. The amplitude of the echoes is modulated by the chemical shift interaction and an inhomogeneity free FID may be recovered by stroboscopically sampling the maxima of the echoes. In an alternative embodiment, full-passage adiabatic pulses are consecutively applied. One embodiment of the apparatus generates a static magnetic field that has a variable saddle point.

Inventors:

Pines, Alexander ^[1]; Meriles, Carlos A ^[2]; Heise, Henrike ^[3]; Sakellariou, Dimitrios ^[4]; Moule, Adam ^[1]

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1. Berkeley, CA
2. El Cerrito, CA
3. Goettingen, DE
4. Oakland, CA

Issue Date:

Tue Jan 06 00:00:00 EST 2004

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

OSTI Identifier:

879818

Patent Number(s):

6674282

Application Number:

10/218974

Assignee:

The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

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G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

G01R33/3808 - {Magnet assemblies for single-sided MR wherein the magnet assembly is located on one side of a subject only
G01R33/445 - {MR involving a non-standard magnetic field B0, e.g. of low magnitude as in the earth's magnetic field or in nanoTesla spectroscopy, comprising a polarizing magnetic field for pre-polarisation, B0 with a temporal variation of its magnitude or direction such as field cycling of B0 or rotation of the direction of B0, or spatially inhomogeneous B0 like in fringe-field MR or in stray-field imaging}
G01R33/46 - NMR spectroscopy
G01R33/4608 - {RF excitation sequences for enhanced detection, e.g. NOE, polarisation transfer, selection of a coherence transfer pathway}
G01R33/4616 - {using specific RF pulses or specific modulation schemes, e.g. stochastic excitation, adiabatic RF pulses, composite pulses, binomial pulses, Shinnar-le-Roux pulses, spectrally selective pulses not being used for spatial selection}
G01R33/48 - NMR imaging systems
G01R33/485 - based on chemical shift information {CSI or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites}

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DOE Contract Number:  

AC03-76SF00098

Resource Type:

Patent

Country of Publication:

United States

Language:

English