Fluorescence based biosensor

Lu, Yi; Liu, Juewen

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A - human necessities
A01 - agriculture
A21 - baking
A22 - butchering
A23 - foods or foodstuffs
A24 - tobacco
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A42 - headwear
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Title: Fluorescence based biosensor

Abstract

A novel biosensor comprises at least one fluorophore and at least two quenchers, and is capable of selectively and specifically detecting the presence of an ion in the presence of other ions.

Inventors:

Lu, Yi ^[1]; Liu, Juewen ^[2]

Champaign, IL
Urbana, IL

Issue Date:: 2005-05-10

Research Org.:: Univ. of Illinois at Urbana-Champaign, IL (United States)

OSTI Identifier:: 879776

Patent Number(s):: 6890719

Application Number:: 10/144094

Assignee:: The Board of Trustess of the University of Illinois (Urbana, IL)

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

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C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/68 - involving nucleic acids
C12Q1/6825 - Nucleic acid detection involving sensors
C12Q2521/337 - Ribozyme
C12Q2541/101 - Selex
C12Q2563/137 - Metal/ion, e.g. metal label
C12Q2565/501 - being an array of oligonucleotides

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S436/80 - Fluorescent dyes, e.g. rhodamine
Y10S977/924 - using nanostructure as support of dna analysis

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/143333 - Saccharide [e.g., DNA, etc.]

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DOE Contract Number:: FG02-01ER63179

Resource Type:: Patent

Country of Publication:: United States

Language:: English

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                    Lu, Yi, and Liu, Juewen. Fluorescence based biosensor.  United States: N. p., 2005. 
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        "Fluorescence based biosensor".  United States.  https://www.osti.gov/servlets/purl/879776.

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@article{osti_879776,

  title        = {Fluorescence based biosensor},

  author       = {Lu, Yi and Liu, Juewen},

  abstractNote = {A novel biosensor comprises at least one fluorophore and at least two quenchers, and is capable of selectively and specifically detecting the presence of an ion in the presence of other ions.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2005},

  month        = {5}

}

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Hybridization-based biosensor containing hairpin probes and use thereof

Patent Miller, Benjamin L [Penfield, NY]; Strohsahl, Christopher M [Rochester, NY]

A sensor chip that includes: a fluorescence quenching surface; a nucleic acid probe that contains first and second ends with the first end bound to the fluorescence quenching surface, and is characterized by being able to self-anneal into a hairpin conformation; and a first fluorophore bound to the second end of the first nucleic acid molecule. When the first nucleic acid molecule is in the hairpin conformation, the fluorescence quenching surface substantially quenches fluorescent emissions by the first fluorophore; and when the first nucleic acid molecule is in a non-hairpin conformation, fluorescent emissions by the fluorophore are substantially free ofmore » « less
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Title: Fluorescence based biosensor

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The Ca2+ Ion as a Cofactor for a Novel RNA-Cleaving Deoxyribozyme journal, December 1996

Fluorescent and Photochemical Probes of Dynamic Biochemical Signals inside Living Cells book, October 1993

In vitro selection of a purine nucleotide-specific hammerheadlike ribozyme journal, March 1998

Photodynamic Fluorescent Metal Ion Sensors with Parts per Billion Sensitivity journal, April 1998

A Fiber-Optic Microarray Biosensor Using Aptamers as Receptors journal, June 2000

Design and optimization of effector-activated ribozyme ligases journal, April 2000

Small-molecule-substrate interactions with a self-aminoacylating ribozyme journal, May 1997

A DNA enzyme with Mg2+-dependent RNA phosphoesterase activity journal, October 1995

Allosteric selection of ribozymes that respond to the second messengers cGMP and cAMP journal, November 1999

Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin journal, August 1997

In vitro evolution of new ribozymes with polynucleotide kinase activity journal, September 1994

Light-directed, spatially addressable parallel chemical synthesis journal, February 1991

Home refinishing, lead paint, and infant blood lead levels. journal, April 1985

Oligonucleotide aptamers that recognize small molecules journal, June 1999

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase journal, August 1990

RNA Cleavage by a DNA Enzyme with Extended Chemical Functionality journal, March 2000

The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage journal, June 1995

Soil contamination from lead in paint chips journal, September 1975

A DNA metalloenzyme with DNA ligase activity journal, June 1995

Peptide platforms for metal ion sensing conference, December 1999

Molecular Beacons: Probes that Fluoresce upon Hybridization journal, March 1996

A Fluorescent Zinc Probe Based on Metal-Induced Peptide Folding journal, January 1996

RNA-catalysed RNA polymerization using nucleoside triphosphates journal, July 1996

Randomization of genes by PCR mutagenesis. journal, August 1992

A Selective, Ratiometric Fluorescent Sensor for Pb 2+ journal, January 2000

RNA-catalysed carbon–carbon bond formation journal, September 1997

Porphyrin Metalation Catalyzed by a Small RNA Molecule journal, January 1996

In vitro selection and characterization of a highly efficient Zn(II)-dependent RNA-cleaving deoxyribozyme journal, January 2000

Optical sensors for determination of heavy metal ions journal, September 1997

Redox Switchable Fluorescent Probe Selective for Either Hg(II) or Cd(II) and Zn(II) journal, June 1999

Light-generated oligonucleotide arrays for rapid DNA sequence analysis. journal, May 1994

In vitro evolution of randomized ribozymes book, January 1996

In vitro selection for altered divalent metal specificity in the RNase P RNA journal, December 1997

Evolution in vitro of an RNA enzyme with altered metal dependence journal, January 1993

Selection of RNA amide synthases journal, September 1997

Properties of an In vitro Selected Pb2+ Cleavage Motif journal, October 1994

Rapid identification and characterization of hammerhead-ribozyme inhibitors using fluorescence-based technology journal, January 2001

Evidence for the metal-cofactor independence of an RNA phosphodiester-cleaving DNA enzyme journal, August 1997

A Selective and Sensitive Fluoroionophore for Hg II , Ag I , and Cu II with Virtually Decoupled Fluorophore and Receptor Units journal, February 2000

Peptide bond formation by in vitro selected ribozymes journal, November 1997

The risk of lead toxicity in homes with lead paint hazard journal, February 1991

High-Density, Covalent Attachment of DNA to Silicon Wafers for Analysis by MALDI-TOF Mass Spectrometry journal, July 1997

An amino acid as a cofactor for a catalytic polynucleotide journal, May 1998

Peptidyl chemosensors incorporating a fret mechanism for detection of Ni(II) journal, August 1998

A small metalloribozyme with a two-step mechanism journal, August 1992

Manual Manufacturing of Oligonucleotide, DNA, and Protein Microchips journal, August 1997

Ribozyme-catalysed amino-acid transfer reactions journal, May 1996

Three-dimensional structure of a hammerhead ribozyme journal, November 1994

DNA enzymes journal, May 1997

Capping DNA with DNA † journal, March 2000

Mutagenic PCR. journal, June 1994

Selected classes of minimised hammerhead ribozyme have very high cleavage rates at low Mg2+ concentration journal, January 1999

Phosphorylating DNA with DNA journal, March 1999

Structural diversity of self-cleaving ribozymes journal, May 2000

Multicolor molecular beacons for allele discrimination journal, January 1998

Desperately seeking sensors journal, July 1995

Design and Evaluation of a Peptidyl Fluorescent Chemosensor for Divalent Zinc journal, January 1996

A general purpose RNA-cleaving DNA enzyme journal, April 1997

Aminoacyl esterase activity of the Tetrahymena ribozyme journal, June 1992

A catalytic DNA for porphyrin metallation journal, September 1996

In vitro evolution of a self-alkylatlng ribozyme journal, April 1995

Designed Signaling Aptamers that Transduce Molecular Recognition to Changes in Fluorescence Intensity journal, March 2000

Covalent Attachment of Hybridizable Oligonucleotides to Glass Supports journal, April 1997

In vitro selection of catalytic RNAs journal, January 1994

In vitro selection of aptamers: the dearth of pure reason journal, June 1996

Structurally complex and highly active RNA ligases derived from random RNA sequences journal, July 1995

Cleavage of an amide bond by a ribozyme journal, January 1995

DNA Probes Using Fluorescence Resonance Energy Transfer (FRET): Designs and Applications journal, November 2001

Expanding the scope of RNA catalysis journal, June 1994

Fluorescence Polarization for Monitoring Ribozyme Reactions in Real Time journal, August 2000

In vitro selection of self-cleaving DNAs journal, December 1996

In vitro evolution of nucleic acids journal, June 1994

In vitro selection of an allosteric ribozyme that transduces analytes to amplicons journal, January 1999

Determination of Picomolar Concentrations of Metal Ions Using Fluorescence Anisotropy: Biosensing with a “Reagentless” Enzyme Transducer journal, November 1998

Adapting Selected Nucleic Acid Ligands (Aptamers) to Biosensors journal, August 1998

A DNA enzyme that cleaves RNA journal, December 1994

The Ca2+ Ion as a Cofactor for a Novel RNA-Cleaving Deoxyribozyme
journal, December 1996

Fluorescent and Photochemical Probes of Dynamic Biochemical Signals inside Living Cells
book, October 1993

In vitro selection of a purine nucleotide-specific hammerheadlike ribozyme
journal, March 1998

Photodynamic Fluorescent Metal Ion Sensors with Parts per Billion Sensitivity
journal, April 1998

A Fiber-Optic Microarray Biosensor Using Aptamers as Receptors
journal, June 2000

Design and optimization of effector-activated ribozyme ligases
journal, April 2000

Small-molecule-substrate interactions with a self-aminoacylating ribozyme
journal, May 1997

A DNA enzyme with Mg2+-dependent RNA phosphoesterase activity
journal, October 1995

Allosteric selection of ribozymes that respond to the second messengers cGMP and cAMP
journal, November 1999

Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin
journal, August 1997

In vitro evolution of new ribozymes with polynucleotide kinase activity
journal, September 1994

Light-directed, spatially addressable parallel chemical synthesis
journal, February 1991

Home refinishing, lead paint, and infant blood lead levels.
journal, April 1985

Oligonucleotide aptamers that recognize small molecules
journal, June 1999

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
journal, August 1990

RNA Cleavage by a DNA Enzyme with Extended Chemical Functionality
journal, March 2000

The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage
journal, June 1995

Soil contamination from lead in paint chips
journal, September 1975

A DNA metalloenzyme with DNA ligase activity
journal, June 1995

Peptide platforms for metal ion sensing
conference, December 1999

Molecular Beacons: Probes that Fluoresce upon Hybridization
journal, March 1996

A Fluorescent Zinc Probe Based on Metal-Induced Peptide Folding
journal, January 1996

RNA-catalysed RNA polymerization using nucleoside triphosphates
journal, July 1996

Randomization of genes by PCR mutagenesis.
journal, August 1992

A Selective, Ratiometric Fluorescent Sensor for Pb ²⁺
journal, January 2000

RNA-catalysed carbon–carbon bond formation
journal, September 1997

Porphyrin Metalation Catalyzed by a Small RNA Molecule
journal, January 1996

In vitro selection and characterization of a highly efficient Zn(II)-dependent RNA-cleaving deoxyribozyme
journal, January 2000

Optical sensors for determination of heavy metal ions
journal, September 1997

Redox Switchable Fluorescent Probe Selective for Either Hg(II) or Cd(II) and Zn(II)
journal, June 1999

Light-generated oligonucleotide arrays for rapid DNA sequence analysis.
journal, May 1994

In vitro evolution of randomized ribozymes
book, January 1996

In vitro selection for altered divalent metal specificity in the RNase P RNA
journal, December 1997

Evolution in vitro of an RNA enzyme with altered metal dependence
journal, January 1993

Selection of RNA amide synthases
journal, September 1997

Properties of an In vitro Selected Pb2+ Cleavage Motif
journal, October 1994

Rapid identification and characterization of hammerhead-ribozyme inhibitors using fluorescence-based technology
journal, January 2001

Evidence for the metal-cofactor independence of an RNA phosphodiester-cleaving DNA enzyme
journal, August 1997

A Selective and Sensitive Fluoroionophore for Hg ^II , Ag ^I , and Cu ^II with Virtually Decoupled Fluorophore and Receptor Units
journal, February 2000

Peptide bond formation by in vitro selected ribozymes
journal, November 1997

The risk of lead toxicity in homes with lead paint hazard
journal, February 1991

High-Density, Covalent Attachment of DNA to Silicon Wafers for Analysis by MALDI-TOF Mass Spectrometry
journal, July 1997

An amino acid as a cofactor for a catalytic polynucleotide
journal, May 1998

Peptidyl chemosensors incorporating a fret mechanism for detection of Ni(II)
journal, August 1998

A small metalloribozyme with a two-step mechanism
journal, August 1992

Manual Manufacturing of Oligonucleotide, DNA, and Protein Microchips
journal, August 1997

Ribozyme-catalysed amino-acid transfer reactions
journal, May 1996

Three-dimensional structure of a hammerhead ribozyme
journal, November 1994

DNA enzymes
journal, May 1997

Capping DNA with DNA ^†
journal, March 2000

Mutagenic PCR.
journal, June 1994

Selected classes of minimised hammerhead ribozyme have very high cleavage rates at low Mg2+ concentration
journal, January 1999

Phosphorylating DNA with DNA
journal, March 1999

Structural diversity of self-cleaving ribozymes
journal, May 2000

Multicolor molecular beacons for allele discrimination
journal, January 1998

Desperately seeking sensors
journal, July 1995

Design and Evaluation of a Peptidyl Fluorescent Chemosensor for Divalent Zinc
journal, January 1996

A general purpose RNA-cleaving DNA enzyme
journal, April 1997

Aminoacyl esterase activity of the Tetrahymena ribozyme
journal, June 1992

A catalytic DNA for porphyrin metallation
journal, September 1996

In vitro evolution of a self-alkylatlng ribozyme
journal, April 1995

Designed Signaling Aptamers that Transduce Molecular Recognition to Changes in Fluorescence Intensity
journal, March 2000

Covalent Attachment of Hybridizable Oligonucleotides to Glass Supports
journal, April 1997

In vitro selection of catalytic RNAs
journal, January 1994

In vitro selection of aptamers: the dearth of pure reason
journal, June 1996

Structurally complex and highly active RNA ligases derived from random RNA sequences
journal, July 1995

Cleavage of an amide bond by a ribozyme
journal, January 1995

DNA Probes Using Fluorescence Resonance Energy Transfer (FRET): Designs and Applications
journal, November 2001

Expanding the scope of RNA catalysis
journal, June 1994

Fluorescence Polarization for Monitoring Ribozyme Reactions in Real Time
journal, August 2000

In vitro selection of self-cleaving DNAs
journal, December 1996

In vitro evolution of nucleic acids
journal, June 1994

In vitro selection of an allosteric ribozyme that transduces analytes to amplicons
journal, January 1999

Determination of Picomolar Concentrations of Metal Ions Using Fluorescence Anisotropy: Biosensing with a “Reagentless” Enzyme Transducer
journal, November 1998

Adapting Selected Nucleic Acid Ligands (Aptamers) to Biosensors
journal, August 1998

A DNA enzyme that cleaves RNA
journal, December 1994