Gastrin Receptor-Avid Peptide Conjugates
Abstract
A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.
- Inventors:
-
- Columbia, MO
- Baltimore, MD
- Ashland, MO
- Issue Date:
- Research Org.:
- Univ. of Missouri, Columbia, MO (United States)
- OSTI Identifier:
- 879767
- Patent Number(s):
- 6921526
- Application Number:
- 10/122611
- Assignee:
- Curators of the University of Missouri (Columbia, MO)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- DOE Contract Number:
- FG02-89ER60875
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Hoffman, Timothy J, Volkert, Wynn A, Li, Ning, Sieckman, Gary, and Higginbotham, Chrys-Ann. Gastrin Receptor-Avid Peptide Conjugates. United States: N. p., 2005.
Web.
Hoffman, Timothy J, Volkert, Wynn A, Li, Ning, Sieckman, Gary, & Higginbotham, Chrys-Ann. Gastrin Receptor-Avid Peptide Conjugates. United States.
Hoffman, Timothy J, Volkert, Wynn A, Li, Ning, Sieckman, Gary, and Higginbotham, Chrys-Ann. Tue .
"Gastrin Receptor-Avid Peptide Conjugates". United States. https://www.osti.gov/servlets/purl/879767.
@article{osti_879767,
title = {Gastrin Receptor-Avid Peptide Conjugates},
author = {Hoffman, Timothy J and Volkert, Wynn A and Li, Ning and Sieckman, Gary and Higginbotham, Chrys-Ann},
abstractNote = {A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {7}
}
Works referenced in this record:
Design and characterization of -melanotropin peptide analogs cyclized through rhenium and technetium metal coordination
journal, October 1998
- Giblin, M. F.; Wang, N.; Hoffman, T. J.
- Proceedings of the National Academy of Sciences, Vol. 95, Issue 22