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Title: Antimocrobial Polymer

Abstract

A polymeric composition having antimicrobial properties and a process for rendering the surface of a substrate antimicrobial are disclosed. The composition comprises a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, (ii) an antimicrobial agent selected from quaternary ammonium compounds, gentian violet compounds, substituted or unsubstituted phenols, biguanide compounds, iodine compounds, and mixtures thereof, and (iii) a crosslinking agent containing functional groups capable of reacting with the amino groups. In one embodiment, the polymer is a polyamide formed from a maleic anhydride or maleic acid ester monomer and alkylamines thereby producing a polyamide having amino substituted alkyl chains on one side of the polyamide backbone; the crosslinking agent is a phosphine having the general formula (A)3P wherein A is hydroxyalkyl; and the antimicrobial agent is chlorhexidine, dimethylchlorophenol, cetyl pyridinium chloride, gentian violet, triclosan, thymol, iodine, and mixtures thereof.

Inventors:
 [1];  [2];  [3]
  1. Utica, OH
  2. Walnut Creek, CA
  3. Columbus, GA
Issue Date:
Research Org.:
Midwest Research Institute, Kansas City, MO (United States)
OSTI Identifier:
879747
Patent Number(s):
6939554
Application Number:
10/068054
Assignee:
Michigan Biotechnology Institute (Lansing, MI)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08G - MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
DOE Contract Number:  
AC36-98GO10337
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

McDonald, William F, Huang, Zhi-Heng, and Wright, Stacy C. Antimocrobial Polymer. United States: N. p., 2005. Web.
McDonald, William F, Huang, Zhi-Heng, & Wright, Stacy C. Antimocrobial Polymer. United States.
McDonald, William F, Huang, Zhi-Heng, and Wright, Stacy C. Tue . "Antimocrobial Polymer". United States. https://www.osti.gov/servlets/purl/879747.
@article{osti_879747,
title = {Antimocrobial Polymer},
author = {McDonald, William F and Huang, Zhi-Heng and Wright, Stacy C},
abstractNote = {A polymeric composition having antimicrobial properties and a process for rendering the surface of a substrate antimicrobial are disclosed. The composition comprises a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, (ii) an antimicrobial agent selected from quaternary ammonium compounds, gentian violet compounds, substituted or unsubstituted phenols, biguanide compounds, iodine compounds, and mixtures thereof, and (iii) a crosslinking agent containing functional groups capable of reacting with the amino groups. In one embodiment, the polymer is a polyamide formed from a maleic anhydride or maleic acid ester monomer and alkylamines thereby producing a polyamide having amino substituted alkyl chains on one side of the polyamide backbone; the crosslinking agent is a phosphine having the general formula (A)3P wherein A is hydroxyalkyl; and the antimicrobial agent is chlorhexidine, dimethylchlorophenol, cetyl pyridinium chloride, gentian violet, triclosan, thymol, iodine, and mixtures thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {9}
}

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Works referenced in this record:

Synthesis and in Vitro Degradation of New Polyvalent Hydrazide Cross-Linked Hydrogels of Hyaluronic Acid
journal, September 1997


Polyacrylic polyhydrazides as reagents for detection of glycoproteins
journal, August 1989


Binding of the basement-membrane glycoprotein laminin to glycosaminoglycans. An affinity-chromatography study
journal, December 1981


Immobilization of protein ligands with methyl vinyl ether-maleic anhydride copolymer
journal, April 1992


Immobilised phosphines incorporating the chiral biopolymers chitosan and chitin
journal, January 1994


Application of tris(hydroxymethyl)phosphine as a coupling agent for alcohol dehydrogenase immobilization
journal, April 1996


Water-soluble tris(hydroxymethyl)phosphine complexes with nickel, palladium, and platinum. Crystal structure of [Pd{P(CH2OH)3}4].cntdot.CH3
journal, July 1992


New polyurethane compositions able to bond high amounts of both albumin and heparin
journal, January 1995


Oriented immobilization of periodateoxidized monoclonal antibodies on amino and hydrazide derivatives of eupergit C
journal, February 1990


Immobilization of glycoconjugates by their oligosaccharides: Use of hydrazido-derivatized matrices
journal, November 1990


P(CH2OH)3? a new coupling reagent for the covalent immobilisation of enzymes
journal, January 1994


The derivatization of oxidized polysaccharides for protein immobilization and affinity chromotography
journal, March 1976


Preparation of surface-modified albumin nanospheres
journal, April 1997