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Title: Method For Screening Microcrystallizations For Crystal Formation

Abstract

A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor solution whose composition varies within the array and a molecule to be crystallized, the drop having a volume of less than 1 microliter; storing the array of microcrystallizations under conditions suitable for molecule crystals to form in the drops in the array; and detecting molecule crystal formation in the drops by taking images of the drops.

Inventors:
 [1]
  1. (Chicago, IL), Stevens, Raymond C. (La Jolla, CA), Schultz, Peter G. (La Jolla, CA), Jaklevic, Joseph M. (Lafayette, CA), Yegian, Derek T. (Oakland, CA), Cornell, Earl W. (Antioch, CA), Nordmeyer, Robert A. (San Leandro, CA)
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
879710
Patent Number(s):
6630006
Application Number:
09/851397
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Santarsiero, Bernard D. Method For Screening Microcrystallizations For Crystal Formation. United States: N. p., 2003. Web.
Santarsiero, Bernard D. Method For Screening Microcrystallizations For Crystal Formation. United States.
Santarsiero, Bernard D. Tue . "Method For Screening Microcrystallizations For Crystal Formation". United States. https://www.osti.gov/servlets/purl/879710.
@article{osti_879710,
title = {Method For Screening Microcrystallizations For Crystal Formation},
author = {Santarsiero, Bernard D.},
abstractNote = {A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor solution whose composition varies within the array and a molecule to be crystallized, the drop having a volume of less than 1 microliter; storing the array of microcrystallizations under conditions suitable for molecule crystals to form in the drops in the array; and detecting molecule crystal formation in the drops by taking images of the drops.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {10}
}

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