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Title: Copolymers for capillary gel electrophoresis

Abstract

This invention relates to an electrophoresis separation medium having a gel matrix of at least one random, linear copolymer comprising a primary comonomer and at least one secondary comonomer, wherein the comonomers are randomly distributed along the copolymer chain. The primary comonomer is an acrylamide or an acrylamide derivative that provides the primary physical, chemical, and sieving properties of the gel matrix. The at least one secondary comonomer imparts an inherent physical, chemical, or sieving property to the copolymer chain. The primary and secondary comonomers are present in a ratio sufficient to induce desired properties that optimize electrophoresis performance. The invention also relates to a method of separating a mixture of biological molecules using this gel matrix, a method of preparing the novel electrophoresis separation medium, and a capillary tube filled with the electrophoresis separation medium.

Inventors:
;
Issue Date:
Research Org.:
SpectruMedix LLC, State College, PA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
879705
Patent Number(s):
6926815
Application Number:
09/843,918
Assignee:
SpectruMedix LLC (State College, PA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
FG02-97ER82461
Resource Type:
Patent
Resource Relation:
Patent File Date: 2001 Apr 30
Country of Publication:
United States
Language:
English

Citation Formats

Liu, Changsheng, and Li, Qingbo. Copolymers for capillary gel electrophoresis. United States: N. p., 2005. Web.
Liu, Changsheng, & Li, Qingbo. Copolymers for capillary gel electrophoresis. United States.
Liu, Changsheng, and Li, Qingbo. Tue . "Copolymers for capillary gel electrophoresis". United States. https://www.osti.gov/servlets/purl/879705.
@article{osti_879705,
title = {Copolymers for capillary gel electrophoresis},
author = {Liu, Changsheng and Li, Qingbo},
abstractNote = {This invention relates to an electrophoresis separation medium having a gel matrix of at least one random, linear copolymer comprising a primary comonomer and at least one secondary comonomer, wherein the comonomers are randomly distributed along the copolymer chain. The primary comonomer is an acrylamide or an acrylamide derivative that provides the primary physical, chemical, and sieving properties of the gel matrix. The at least one secondary comonomer imparts an inherent physical, chemical, or sieving property to the copolymer chain. The primary and secondary comonomers are present in a ratio sufficient to induce desired properties that optimize electrophoresis performance. The invention also relates to a method of separating a mixture of biological molecules using this gel matrix, a method of preparing the novel electrophoresis separation medium, and a capillary tube filled with the electrophoresis separation medium.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {8}
}

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Works referenced in this record:

Multiplexed fluorescence detector for capillary electrophoresis using axial optical fiber illumination
journal, April 1993


High-Speed DNA Sequencing by Using Mixed Poly(ethylene oxide) Solutions in Uncoated Capillary Columns
journal, July 1995


Separations of DNA fragments by capillary electrophoresis in N-substituted polyacrylamides
journal, September 1997


Separation of polyelectrolytes of variable compositions by free-zone capillary electrophoresis
journal, April 1997