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Title: Antithrombogenic Polymer Coating.

Abstract

An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side chains, a crosslinking agent containing at least two crosslinking functional groups which react with amino groups on the polymer, and a linking agent containing a first functional group which reacts with a third functional group of the crosslinking agent, and (ii) contacting the coating on the substrate with an antithrombogenic agent which covalently bonds to a second functional group of the linking agent. In one example embodiment, the polymer is a polyamide having amino substituted alkyl chains on one side of the polyamide backbone, the crosslinking agent is a phosphine having the general formula (A).sub.3 P wherein A is hydroxyalkyl, the linking agent is a polyhydrazide and the antithrombogenic agent is heparin.

Inventors:
 [1];  [2];  [3];  [4]
  1. (San Ramon, CA)
  2. (Utica, OH)
  3. (Flint, MI)
  4. (Ann Arbor, MI)
Issue Date:
OSTI Identifier:
879678
Patent Number(s):
6509104
Application Number:
09/730098
Assignee:
Michigan Biotechnology Institute (Lansing, MI) OSTI
DOE Contract Number:  
XXE-9-29058-01
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Huang, Zhi Heng, McDonald, William F., Wright, Stacy C., and Taylor, Andrew C. Antithrombogenic Polymer Coating.. United States: N. p., 2003. Web.
Huang, Zhi Heng, McDonald, William F., Wright, Stacy C., & Taylor, Andrew C. Antithrombogenic Polymer Coating.. United States.
Huang, Zhi Heng, McDonald, William F., Wright, Stacy C., and Taylor, Andrew C. Tue . "Antithrombogenic Polymer Coating.". United States. https://www.osti.gov/servlets/purl/879678.
@article{osti_879678,
title = {Antithrombogenic Polymer Coating.},
author = {Huang, Zhi Heng and McDonald, William F. and Wright, Stacy C. and Taylor, Andrew C.},
abstractNote = {An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side chains, a crosslinking agent containing at least two crosslinking functional groups which react with amino groups on the polymer, and a linking agent containing a first functional group which reacts with a third functional group of the crosslinking agent, and (ii) contacting the coating on the substrate with an antithrombogenic agent which covalently bonds to a second functional group of the linking agent. In one example embodiment, the polymer is a polyamide having amino substituted alkyl chains on one side of the polyamide backbone, the crosslinking agent is a phosphine having the general formula (A).sub.3 P wherein A is hydroxyalkyl, the linking agent is a polyhydrazide and the antithrombogenic agent is heparin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {1}
}

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