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Title: Antithrombogenic Polymer Coating.

Abstract

An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side chains, a crosslinking agent containing at least two crosslinking functional groups which react with amino groups on the polymer, and a linking agent containing a first functional group which reacts with a third functional group of the crosslinking agent, and (ii) contacting the coating on the substrate with an antithrombogenic agent which covalently bonds to a second functional group of the linking agent. In one example embodiment, the polymer is a polyamide having amino substituted alkyl chains on one side of the polyamide backbone, the crosslinking agent is a phosphine having the general formula (A).sub.3 P wherein A is hydroxyalkyl, the linking agent is a polyhydrazide and the antithrombogenic agent is heparin.

Inventors:
 [1];  [2];  [3];  [4]
  1. San Ramon, CA
  2. Utica, OH
  3. Flint, MI
  4. Ann Arbor, MI
Issue Date:
OSTI Identifier:
879678
Patent Number(s):
6509104
Application Number:
09/730098
Assignee:
Michigan Biotechnology Institute (Lansing, MI)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
DOE Contract Number:  
XXE-9-29058-01
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Huang, Zhi Heng, McDonald, William F, Wright, Stacy C, and Taylor, Andrew C. Antithrombogenic Polymer Coating.. United States: N. p., 2003. Web.
Huang, Zhi Heng, McDonald, William F, Wright, Stacy C, & Taylor, Andrew C. Antithrombogenic Polymer Coating.. United States.
Huang, Zhi Heng, McDonald, William F, Wright, Stacy C, and Taylor, Andrew C. Tue . "Antithrombogenic Polymer Coating.". United States. https://www.osti.gov/servlets/purl/879678.
@article{osti_879678,
title = {Antithrombogenic Polymer Coating.},
author = {Huang, Zhi Heng and McDonald, William F and Wright, Stacy C and Taylor, Andrew C},
abstractNote = {An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side chains, a crosslinking agent containing at least two crosslinking functional groups which react with amino groups on the polymer, and a linking agent containing a first functional group which reacts with a third functional group of the crosslinking agent, and (ii) contacting the coating on the substrate with an antithrombogenic agent which covalently bonds to a second functional group of the linking agent. In one example embodiment, the polymer is a polyamide having amino substituted alkyl chains on one side of the polyamide backbone, the crosslinking agent is a phosphine having the general formula (A).sub.3 P wherein A is hydroxyalkyl, the linking agent is a polyhydrazide and the antithrombogenic agent is heparin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {1}
}

Works referenced in this record:

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journal, August 1989


Synthesis and in Vitro Degradation of New Polyvalent Hydrazide Cross-Linked Hydrogels of Hyaluronic Acid
journal, September 1997


The Search for Thromboresistance Using Immobilized Heparin
journal, December 1987


A New Method for Direct Detection of Heparin on Surface-Modified Intraocular Lenses
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Binding of the basement-membrane glycoprotein laminin to glycosaminoglycans. An affinity-chromatography study
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Controlled chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of hydrazide derivatives
journal, April 1998


Immobilization of protein ligands with methyl vinyl ether-maleic anhydride copolymer
journal, April 1992


Colorimetric method for the assay of heparin content in immobilized heparin preparations
journal, December 1980


Immobilised phosphines incorporating the chiral biopolymers chitosan and chitin
journal, January 1994


Application of tris(hydroxymethyl)phosphine as a coupling agent for alcohol dehydrogenase immobilization
journal, April 1996


Water-soluble tris(hydroxymethyl)phosphine complexes with nickel, palladium, and platinum. Crystal structure of [Pd{P(CH2OH)3}4].cntdot.CH3
journal, July 1992


New polyurethane compositions able to bond high amounts of both albumin and heparin
journal, January 1995


Oriented immobilization of periodateoxidized monoclonal antibodies on amino and hydrazide derivatives of eupergit C
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Immobilization of glycoconjugates by their oligosaccharides: Use of hydrazido-derivatized matrices
journal, November 1990


P(CH2OH)3? a new coupling reagent for the covalent immobilisation of enzymes
journal, January 1994


Dermatan Sulfate-Reactive Lectin from Chicken Liver
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The derivatization of oxidized polysaccharides for protein immobilization and affinity chromotography
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Preparation of surface-modified albumin nanospheres
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