Method And Apparatus For Reducing Sample Dispersion In Turns And Junctions Of Micro-Channel Systems
Abstract
What is disclosed pertains to improvement in the performance of microchannel devices by providing turns, wyes, tees, and other junctions that produce little dispersion of a sample as it traverses the turn or junction. The reduced dispersion results from contraction and expansion regions that reduce the cross-sectional area over some portion of the turn or junction. By carefully designing the geometries of these regions, sample dispersion in turns and junctions is reduced to levels comparable to the effects of ordinary diffusion. The low dispersion features are particularly suited for microfluidic devices and systems using either electromotive force, pressure, or combinations thereof as the principle of fluid transport. Such microfluidic devices and systems are useful for separation of components, sample transport, reaction, mixing, dilution or synthesis, or combinations thereof.
- Inventors:
-
- (Danville, CA), Nilson, Robert H. (Cardiff-by-the-Sea, CA)
- Issue Date:
- Research Org.:
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
- OSTI Identifier:
- 879675
- Patent Number(s):
- 6733730
- Application Number:
- 09/707337
- Assignee:
- Sandia Corporation (Albuquerque, NM)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Griffiths, Stewart K. Method And Apparatus For Reducing Sample Dispersion In Turns And Junctions Of Micro-Channel Systems. United States: N. p., 2004.
Web.
Griffiths, Stewart K. Method And Apparatus For Reducing Sample Dispersion In Turns And Junctions Of Micro-Channel Systems. United States.
Griffiths, Stewart K. Tue .
"Method And Apparatus For Reducing Sample Dispersion In Turns And Junctions Of Micro-Channel Systems". United States. https://www.osti.gov/servlets/purl/879675.
@article{osti_879675,
title = {Method And Apparatus For Reducing Sample Dispersion In Turns And Junctions Of Micro-Channel Systems},
author = {Griffiths, Stewart K.},
abstractNote = {What is disclosed pertains to improvement in the performance of microchannel devices by providing turns, wyes, tees, and other junctions that produce little dispersion of a sample as it traverses the turn or junction. The reduced dispersion results from contraction and expansion regions that reduce the cross-sectional area over some portion of the turn or junction. By carefully designing the geometries of these regions, sample dispersion in turns and junctions is reduced to levels comparable to the effects of ordinary diffusion. The low dispersion features are particularly suited for microfluidic devices and systems using either electromotive force, pressure, or combinations thereof as the principle of fluid transport. Such microfluidic devices and systems are useful for separation of components, sample transport, reaction, mixing, dilution or synthesis, or combinations thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2004},
month = {5}
}
Works referenced in this record:
Coiled columns and resolution in gas chromatography
journal, January 1960
- Calvin Giddings, J.
- Journal of Chromatography A, Vol. 3
Dispersion Sources for Compact Geometries on Microchips
journal, September 1998
- Culbertson, Christopher T.; Jacobson, Stephen C.; Ramsey, J. Michael
- Analytical Chemistry, Vol. 70, Issue 18
Free boundary problem of ECM by alternating-field technique on inverted plane
journal, November 1975
- Nilson, R. H.; Tsuei, Y. G.
- Computer Methods in Applied Mechanics and Engineering, Vol. 6, Issue 3
Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices
journal, April 1994
- Jacobson, Stephen C.; Hergenroder, Roland.; Koutny, Lance B.
- Analytical Chemistry, Vol. 66, Issue 7
Contribution of capillary coiling to zone dispersion in capillary zone electrophoresis
journal, January 1995
- Kašička, Václav; Prusík, Zdeněk; Gaš, Bohuslav
- Electrophoresis, Vol. 16, Issue 1
Wormhole growth in soluble porous materials
journal, September 1990
- Nilson, Robert H.; Griffiths, Stewart K.
- Physical Review Letters, Vol. 65, Issue 13
Transport, Manipulation, and Reaction of Biological Cells On-Chip Using Electrokinetic Effects
journal, April 1997
- Li, Paul C. H.; Harrison, D. Jed
- Analytical Chemistry, Vol. 69, Issue 8