Method And Apparatus For Examining A Tissue Using The Spectral Wing Emission Therefrom Induced By Visible To Infrared Photoexcitation.

Title: Method And Apparatus For Examining A Tissue Using The Spectral Wing Emission Therefrom Induced By Visible To Infrared Photoexcitation.

Abstract

Method and an apparatus for examining a tissue using the spectral wing emission therefrom induced by visible to infrared photoexcitation. In one aspect, the method is used to characterize the condition of a tissue sample and comprises the steps of (a) photoexciting the tissue sample with substantially monochromatic light having a wavelength of at least 600 nm; and (b) using the resultant far red and near infrared spectral wing emission (SW) emitted from the tissue sample to characterize the condition of the tissue sample. In one embodiment, the substantially monochromatic photoexciting light is a continuous beam of light, and the resultant steady-state far red and near infrared SW emission from the tissue sample is used to characterize the condition of the tissue sample. In another embodiment, the substantially monochromatic photoexciting light is a light pulse, and the resultant time-resolved far red and near infrared SW emission emitted from the tissue sample is used to characterize the condition of the tissue sample. In still another embodiment, the substantially monochromatic photoexciting light is a polarized light pulse, and the parallel and perpendicular components of the resultant polarized time-resolved SW emission emitted from the tissue sample are used to characterize the condition ofmore » the tissue sample.« less

Inventors:

Alfano, Robert R ^[1]; Demos, Stavros G ^[2]; Zhang, Gang ^[3]

3777 Independence Ave., Bronx, NY 10463
3550 Pacific Ave., Apt. 304, Livermore, CA 94550
3 Rieder Rd., Edison, NJ 08817

Issue Date:: 2003-12-16

Research Org.:: City Univ. of New York (CUNY), NY (United States)

OSTI Identifier:: 879642

Patent Number(s):: 6665556

Application Number:: 09/493939

Assignee:: Alfano, Robert R. (3777 Independence Ave., Bronx, NY 10463); Demos, Stavros G. (3550 Pacific Ave., Apt. 304, Livermore, CA 94550); Zhang, Gang (3 Rieder Rd., Edison, NJ 08817)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B1/0638 - {providing two or more wavelengths}
A61B1/043 - {for fluorescence imaging}
A61B5/0071 - {by measuring fluorescence emission}
A61B5/0075 - {by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
A61B1/063 - {for monochromatic illumination}
A61B5/0084 - {for introduction into the body, e.g. by catheters

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DOE Contract Number:: FG02-98ER62560

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Citation Formats


                    Alfano, Robert R, Demos, Stavros G, and Zhang, Gang. Method And Apparatus For Examining A Tissue Using The Spectral Wing Emission Therefrom Induced By Visible To Infrared Photoexcitation..  United States: N. p., 2003. 
        Web.

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                    Alfano, Robert R, Demos, Stavros G, & Zhang, Gang. Method And Apparatus For Examining A Tissue Using The Spectral Wing Emission Therefrom Induced By Visible To Infrared Photoexcitation..  United States.

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                    Alfano, Robert R, Demos, Stavros G, and Zhang, Gang. Tue .  
        "Method And Apparatus For Examining A Tissue Using The Spectral Wing Emission Therefrom Induced By Visible To Infrared Photoexcitation.".  United States.  https://www.osti.gov/servlets/purl/879642.

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@article{osti_879642,

  title        = {Method And Apparatus For Examining A Tissue Using The Spectral Wing Emission Therefrom Induced By Visible To Infrared Photoexcitation.},

  author       = {Alfano, Robert R and Demos, Stavros G and Zhang, Gang},

  abstractNote = {Method and an apparatus for examining a tissue using the spectral wing emission therefrom induced by visible to infrared photoexcitation. In one aspect, the method is used to characterize the condition of a tissue sample and comprises the steps of (a) photoexciting the tissue sample with substantially monochromatic light having a wavelength of at least 600 nm; and (b) using the resultant far red and near infrared spectral wing emission (SW) emitted from the tissue sample to characterize the condition of the tissue sample. In one embodiment, the substantially monochromatic photoexciting light is a continuous beam of light, and the resultant steady-state far red and near infrared SW emission from the tissue sample is used to characterize the condition of the tissue sample. In another embodiment, the substantially monochromatic photoexciting light is a light pulse, and the resultant time-resolved far red and near infrared SW emission emitted from the tissue sample is used to characterize the condition of the tissue sample. In still another embodiment, the substantially monochromatic photoexciting light is a polarized light pulse, and the parallel and perpendicular components of the resultant polarized time-resolved SW emission emitted from the tissue sample are used to characterize the condition of the tissue sample.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2003},

  month        = {12}

}

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Works referenced in this record:

Near-infrared Fluorescence Spectroscopy Detects Alzheimer's Disease In Vitro
journal, August 1999

Hanlon, Eugene B.; Itzkan, Irving; Dasari, Ramachandra R.
Photochemistry and Photobiology, Vol. 70, Issue 2
https://doi.org/10.1111/j.1751-1097.1999.tb07994.x

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Title: Method And Apparatus For Examining A Tissue Using The Spectral Wing Emission Therefrom Induced By Visible To Infrared Photoexcitation.

Abstract

Citation Formats

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