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Title: Nucleic Acid Encoding A Lectin-Derived Progenitor Cell Preservation Factor

Abstract

The invention relates to an isolated nucleic acid molecule that encodes a protein that is effective to preserve progenitor cells, such as hematopoietic progenitor cells. The nucleic acid comprises a sequence defined by SEQ ID NO:1, a homolog thereof, or a fragment thereof. The encoded protein has an amino acid sequence that comprises a sequence defined by SEQ ID NO:2, a homolog thereof, or a fragment thereof that contains an amino acid sequence TNNVLQVT. Methods of using the encoded protein for preserving progenitor cells in vitro, ex vivo, and in vivo are also described. The invention, therefore, include methods such as myeloablation therapies for cancer treatment wherein myeloid reconstitution is facilitated by means of the specified protein. Other therapeutic utilities are also enabled through the invention, for example, expanding progenitor cell populations ex vivo to increase chances of engraftation, improving conditions for transporting and storing progenitor cells, and facilitating gene therapy to treat and cure a broad range of life-threatening hematologic diseases.

Inventors:
 [1];  [2];  [3]
  1. Dugenta, IT
  2. La Jolla, CA
  3. New York, NY
Issue Date:
Research Org.:
Univ. of California (United States)
OSTI Identifier:
879431
Patent Number(s):
6310195
Application Number:
08/881189
Assignee:
ImClone Systems Incorporated (New York, NY)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
FG03-86ER13497
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Colucci, M Gabriella, Chrispeels, Maarten J, and Moore, Jeffrey G. Nucleic Acid Encoding A Lectin-Derived Progenitor Cell Preservation Factor. United States: N. p., 2001. Web.
Colucci, M Gabriella, Chrispeels, Maarten J, & Moore, Jeffrey G. Nucleic Acid Encoding A Lectin-Derived Progenitor Cell Preservation Factor. United States.
Colucci, M Gabriella, Chrispeels, Maarten J, and Moore, Jeffrey G. Tue . "Nucleic Acid Encoding A Lectin-Derived Progenitor Cell Preservation Factor". United States. https://www.osti.gov/servlets/purl/879431.
@article{osti_879431,
title = {Nucleic Acid Encoding A Lectin-Derived Progenitor Cell Preservation Factor},
author = {Colucci, M Gabriella and Chrispeels, Maarten J and Moore, Jeffrey G},
abstractNote = {The invention relates to an isolated nucleic acid molecule that encodes a protein that is effective to preserve progenitor cells, such as hematopoietic progenitor cells. The nucleic acid comprises a sequence defined by SEQ ID NO:1, a homolog thereof, or a fragment thereof. The encoded protein has an amino acid sequence that comprises a sequence defined by SEQ ID NO:2, a homolog thereof, or a fragment thereof that contains an amino acid sequence TNNVLQVT. Methods of using the encoded protein for preserving progenitor cells in vitro, ex vivo, and in vivo are also described. The invention, therefore, include methods such as myeloablation therapies for cancer treatment wherein myeloid reconstitution is facilitated by means of the specified protein. Other therapeutic utilities are also enabled through the invention, for example, expanding progenitor cell populations ex vivo to increase chances of engraftation, improving conditions for transporting and storing progenitor cells, and facilitating gene therapy to treat and cure a broad range of life-threatening hematologic diseases.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {10}
}

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