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Title: Robust Accurate Non-Invasive Analyte Monitor

Abstract

An improved method and apparatus for determining noninvasively and in vivo one or more unknown values of a known characteristic, particularly the concentration of an analyte in human tissue. The method includes: (1) irradiating the tissue with infrared energy (400 nm-2400 nm) having at least several wavelengths in a given range of wavelengths so that there is differential absorption of at least some of the wavelengths by the tissue as a function of the wavelengths and the known characteristic, the differential absorption causeing intensity variations of the wavelengths incident from the tissue; (2) providing a first path through the tissue; (3) optimizing the first path for a first sub-region of the range of wavelengths to maximize the differential absorption by at least some of the wavelengths in the first sub-region; (4) providing a second path through the tissue; and (5) optimizing the second path for a second sub-region of the range, to maximize the differential absorption by at least some of the wavelengths in the second sub-region. In the preferred embodiment a third path through the tissue is provided for, which path is optimized for a third sub-region of the range. With this arrangement, spectral variations which are the resultmore » of tissue differences (e.g., melanin and temperature) can be reduced. At least one of the paths represents a partial transmission path through the tissue. This partial transmission path may pass through the nail of a finger once and, preferably, twice. Also included are apparatus for: (1) reducing the arterial pulsations within the tissue; and (2) maximizing the blood content i the tissue.« less

Inventors:
 [1]
  1. 1603 Solano NE., Albuquerque, NM 87110
Issue Date:
OSTI Identifier:
879399
Patent Number(s):
5830132
Application Number:
08/794677
Assignee:
Robinson, Mark R. (1603 Solano NE., Albuquerque, NM 87110)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Robinson, Mark R. Robust Accurate Non-Invasive Analyte Monitor. United States: N. p., 1998. Web.
Robinson, Mark R. Robust Accurate Non-Invasive Analyte Monitor. United States.
Robinson, Mark R. Tue . "Robust Accurate Non-Invasive Analyte Monitor". United States. https://www.osti.gov/servlets/purl/879399.
@article{osti_879399,
title = {Robust Accurate Non-Invasive Analyte Monitor},
author = {Robinson, Mark R},
abstractNote = {An improved method and apparatus for determining noninvasively and in vivo one or more unknown values of a known characteristic, particularly the concentration of an analyte in human tissue. The method includes: (1) irradiating the tissue with infrared energy (400 nm-2400 nm) having at least several wavelengths in a given range of wavelengths so that there is differential absorption of at least some of the wavelengths by the tissue as a function of the wavelengths and the known characteristic, the differential absorption causeing intensity variations of the wavelengths incident from the tissue; (2) providing a first path through the tissue; (3) optimizing the first path for a first sub-region of the range of wavelengths to maximize the differential absorption by at least some of the wavelengths in the first sub-region; (4) providing a second path through the tissue; and (5) optimizing the second path for a second sub-region of the range, to maximize the differential absorption by at least some of the wavelengths in the second sub-region. In the preferred embodiment a third path through the tissue is provided for, which path is optimized for a third sub-region of the range. With this arrangement, spectral variations which are the result of tissue differences (e.g., melanin and temperature) can be reduced. At least one of the paths represents a partial transmission path through the tissue. This partial transmission path may pass through the nail of a finger once and, preferably, twice. Also included are apparatus for: (1) reducing the arterial pulsations within the tissue; and (2) maximizing the blood content i the tissue.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {11}
}

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Works referenced in this record:

Post-Prandial Blood Glucose Determination by Quantitative Mid-Infrared Spectroscopy
journal, June 1992


The Optics of Human Skin
journal, July 1981


Noninvasive Glucose Monitoring in Diabetic Patients: A Preliminary Evaluation
journal, September 1992


Near-IR fiber-optic probe for electrolytes in aqueous solution
journal, February 1993


Reagentless Near-Infrared Determination of Glucose in Whole Blood Using Multivariate Calibration
journal, October 1992


Acousto-Optic Devices: Optical Elements for Spectroscopy
journal, October 1992