Robust Accurate Non-Invasive Analyte Monitor

Robinson, Mark R

Title: Robust Accurate Non-Invasive Analyte Monitor

Abstract

An improved method and apparatus for determining noninvasively and in vivo one or more unknown values of a known characteristic, particularly the concentration of an analyte in human tissue. The method includes: (1) irradiating the tissue with infrared energy (400 nm-2400 nm) having at least several wavelengths in a given range of wavelengths so that there is differential absorption of at least some of the wavelengths by the tissue as a function of the wavelengths and the known characteristic, the differential absorption causeing intensity variations of the wavelengths incident from the tissue; (2) providing a first path through the tissue; (3) optimizing the first path for a first sub-region of the range of wavelengths to maximize the differential absorption by at least some of the wavelengths in the first sub-region; (4) providing a second path through the tissue; and (5) optimizing the second path for a second sub-region of the range, to maximize the differential absorption by at least some of the wavelengths in the second sub-region. In the preferred embodiment a third path through the tissue is provided for, which path is optimized for a third sub-region of the range. With this arrangement, spectral variations which are the resultmore » « less

Inventors:

Robinson, Mark R ^[1]

1603 Solano NE., Albuquerque, NM 87110

Issue Date:: 1998-11-03

OSTI Identifier:: 879399

Patent Number(s):: 5830132

Application Number:: 08/794677

Assignee:: Robinson, Mark R. (1603 Solano NE., Albuquerque, NM 87110)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

Show more

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N2201/0621 - Supply

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B5/1455 - using optical sensors, e.g. spectral photometrical oximeters
A61B2562/0233 - Special features of optical sensors or probes classified in A61B5/00

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N21/3151 - {using two sources of radiation of different wavelengths
G01N21/49 - within a body or fluid

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B5/14532 - {for measuring glucose, e.g. by tissue impedance measurement}

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N21/359 - using near infra-red light

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B2562/046 - in a matrix array

Show less

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Citation Formats


                    Robinson, Mark R. Robust Accurate Non-Invasive Analyte Monitor.  United States: N. p., 1998. 
        Web.

Copy to clipboard


                    Robinson, Mark R. Robust Accurate Non-Invasive Analyte Monitor.  United States.

Copy to clipboard


                    Robinson, Mark R. Tue .  
        "Robust Accurate Non-Invasive Analyte Monitor".  United States.  https://www.osti.gov/servlets/purl/879399.

Copy to clipboard


                    
@article{osti_879399,

  title        = {Robust Accurate Non-Invasive Analyte Monitor},

  author       = {Robinson, Mark R},

  abstractNote = {An improved method and apparatus for determining noninvasively and in vivo one or more unknown values of a known characteristic, particularly the concentration of an analyte in human tissue. The method includes: (1) irradiating the tissue with infrared energy (400 nm-2400 nm) having at least several wavelengths in a given range of wavelengths so that there is differential absorption of at least some of the wavelengths by the tissue as a function of the wavelengths and the known characteristic, the differential absorption causeing intensity variations of the wavelengths incident from the tissue; (2) providing a first path through the tissue; (3) optimizing the first path for a first sub-region of the range of wavelengths to maximize the differential absorption by at least some of the wavelengths in the first sub-region; (4) providing a second path through the tissue; and (5) optimizing the second path for a second sub-region of the range, to maximize the differential absorption by at least some of the wavelengths in the second sub-region. In the preferred embodiment a third path through the tissue is provided for, which path is optimized for a third sub-region of the range. With this arrangement, spectral variations which are the result of tissue differences (e.g., melanin and temperature) can be reduced. At least one of the paths represents a partial transmission path through the tissue. This partial transmission path may pass through the nail of a finger once and, preferably, twice. Also included are apparatus for: (1) reducing the arterial pulsations within the tissue; and (2) maximizing the blood content i the tissue.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1998},

  month        = {11}

}

Copy to clipboard

Patent:

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Post-Prandial Blood Glucose Determination by Quantitative Mid-Infrared Spectroscopy
journal, June 1992

Ward, Kenneth J.; Haaland, David M.; Robinson, M. Ries
Applied Spectroscopy, Vol. 46, Issue 6
https://doi.org/10.1366/0003702924124493

The Optics of Human Skin
journal, July 1981

Anderson, R. Rox; Parrish, John A.
Journal of Investigative Dermatology, Vol. 77, Issue 1, p. 13-19
https://doi.org/10.1111/1523-1747.ep12479191

Noninvasive Glucose Monitoring in Diabetic Patients: A Preliminary Evaluation
journal, September 1992

Robinson, M. R.; Eaton, R. P.; Haaland, D. M.
Clinical Chemistry, Vol. 38, Issue 9
https://doi.org/10.1093/clinchem/38.9.1618

Near-IR fiber-optic probe for electrolytes in aqueous solution
journal, February 1993

Lin, Jie.; Brown, Chris W.
Analytical Chemistry, Vol. 65, Issue 3
https://doi.org/10.1021/ac00051a017

Reagentless Near-Infrared Determination of Glucose in Whole Blood Using Multivariate Calibration
journal, October 1992

Haaland, David M.; Robinson, M. Ries; Koepp, Gary W.
Applied Spectroscopy, Vol. 46, Issue 10
https://doi.org/10.1366/000370292789619232

Acousto-Optic Devices: Optical Elements for Spectroscopy
journal, October 1992

Tran, Chieu D.
Analytical Chemistry, Vol. 64, Issue 20
https://doi.org/10.1021/ac00044a001

Similar Records in DOE Patents and OSTI.GOV collections:

Non-invasive, in situ diagnosis and monitoring of corrosion in high temperature systems

Patent Findikoglu, Alp Tugrul; Goff, George Scott

Techniques for non-invasive diagnosis and/or monitoring of corrosion in high temperature systems using specialized sensors that produce multi-mode acoustic signals in situ for accurate determination of wall loss and/or physical property changes for a vessel in contact with a high temperature, highly corrosive substance are disclosed. Sensitivity of a few microns (or about 0.1%) of wall loss, detection of changes in physical properties of vessel contents (e.g., approximately 1%), or both, at temperatures of 500° C., 600° C., or higher may be realized. Corrosion may be identified and/or monitored using time domain, frequency domain, or mixed time domain and frequencymore » « less
Full Text Available
Gravity-based, non-invasive reactor system and method for coolant inventory monitoring

Patent Bloom, Scott Harris; Prelewicz, Daniel Adam; Ridgway, Jeffrey Richard

A gravity-based, non-invasive method of measuring a level of fluid in a container comprises use of at least one gravity meter located as proximate a center of mass of the fluid as possible. In a nuclear reactor system a method for monitoring the level of fluid in a nuclear reactor module, a report of a loss or gain of fluid within a cylindrical module may be generated from capturing a time series of gravity data from a first gravity meter mounted as an upper gravity meter and a second gravity meter mounted as a lower gravity meter, for example, proximatemore » « less
Full Text Available
Method and apparatus for non-invasive monitoring of blood glucose

Patent Thomas, Graham H [Livermore, CA]; Watson, Roger M [Modesto, CA]; Noell, J Oakey [Mishawaka, IN]

A new and improved method and apparatus are provided for non-invasive monitoring of changes in blood glucose concentration in a tissue specimen and particularly in an individual. The method uses acoustic velocity measurements for monitoring the effect of glucose concentration upon the density and adiabatic compressibility of the serum. In a preferred embodiment, the acoustic velocity measurements are made through the earlobe of a subject by means of an acoustic probe or monitor which includes a transducer for transmitting and receiving ultrasonic energy pulses to and from the blood flowing in the subject's earlobe and a reflector for facilitating reflectionmore » « less
Full Text Available
Non-invasive hyperthermia apparatus including coaxial applicator having a non-invasive radiometric receiving antenna incorporated therein and method of use thereof

Patent Ross, Michael P [Albquuerque, NM]

A coaxial hyperthermia applicator for applying non-invasively electromagnetic energy to a body against which it is placed. The coaxial applicator antenna has formed integrally within it a non-invasive radiometric antenna for receiving thermoelectromagnetic emissions. The coaxial-configured applicator produces a bell-shaped radiation pattern symmetric about the axis of symmetry of the coaxial applicator. Integrating the radiometric antenna within the coaxial applicator produces a single device that performs dual functions. The first function is to transmit non-invasively energy for heating a subcutaneous tumor. The second function is to receive non-invasively thermal electromagnetic radiation from the tumor by which temperature is sensed andmore » « less
Full Text Available
Single-cell raman spectroscopy for the non-destructive, non-invasive analysis of cells and cellular components

Patent Chan, James W.; Huser, Thomas R.; Lane, Stephen M.; ...

Raman spectra of cells, such as normal human T- and B-cells from peripheral blood or human tonsil and the corresponding transformed cells are obtained by optically trapping the cells and obtaining their Raman spectra. The trapped cells can be subjected to one, two, or more different excitation wavelengths, and each wavelength of the corresponding Raman spectra can be stored in a separate channel. In preferred embodiments, two spectra are subtracted from each other to give a difference spectrum and each channel is analyzed independently to characterize the trapped cell. Alternatively, the Raman spectrum can be subjected to Principal Component Analysismore » « less
Full Text Available

Similar Records

Title: Robust Accurate Non-Invasive Analyte Monitor

Abstract

Citation Formats

Post-Prandial Blood Glucose Determination by Quantitative Mid-Infrared Spectroscopy journal, June 1992

The Optics of Human Skin journal, July 1981

Noninvasive Glucose Monitoring in Diabetic Patients: A Preliminary Evaluation journal, September 1992

Near-IR fiber-optic probe for electrolytes in aqueous solution journal, February 1993

Reagentless Near-Infrared Determination of Glucose in Whole Blood Using Multivariate Calibration journal, October 1992

Acousto-Optic Devices: Optical Elements for Spectroscopy journal, October 1992

Post-Prandial Blood Glucose Determination by Quantitative Mid-Infrared Spectroscopy
journal, June 1992

The Optics of Human Skin
journal, July 1981

Noninvasive Glucose Monitoring in Diabetic Patients: A Preliminary Evaluation
journal, September 1992

Near-IR fiber-optic probe for electrolytes in aqueous solution
journal, February 1993

Reagentless Near-Infrared Determination of Glucose in Whole Blood Using Multivariate Calibration
journal, October 1992

Acousto-Optic Devices: Optical Elements for Spectroscopy
journal, October 1992