Use Of Green Porphyrinsto Treat Neovasculature In The Eyes

Levy, Julia; Miller, Joan W; Gradoudas, Evangelos S; Hasan, Tayyaba; Schmidt-Erfurth, Ursula

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Title: Use Of Green Porphyrinsto Treat Neovasculature In The Eyes

Abstract

Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions.

Inventors:

Levy, Julia ^[1]; Miller, Joan W ^[2]; Gradoudas, Evangelos S ^[2]; Hasan, Tayyaba ^[3]; Schmidt-Erfurth, Ursula ^[4]

Vancouver, CA
Boston, MA
Arlington, MA
Luebeck, DE

Issue Date:: 1998-08-25

Research Org.:: Massachusetts General Hospital

OSTI Identifier:: 879252

Patent Number(s):: 5798349

Application Number:: 08/390591

Assignee:: The General Hospital Corporation (Boston, MA); Quadra Logic Technologies, Inc. (Vancouver, B.C., CA); Massachuesetts Eye & Ear Infirmary (Boston, MA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61F - FILTERS IMPLANTABLE INTO BLOOD VESSELS

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61F - FILTERS IMPLANTABLE INTO BLOOD VESSELS
A61F9/008 - using laser

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/409 - having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
A61K31/555 - containing heavy metals, e.g. hemin, hematin, melarsoprol
A61K41/0071 - {PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines}
A61K49/0036 - {Porphyrins
A61K49/0084 - {liposome, i.e. bilayered vesicular structure}
A61K9/0019 - {Injectable compositions
A61K9/1275 - {Lipoproteins

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DOE Contract Number:: FG02-91ER61228

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Citation Formats


                    Levy, Julia, Miller, Joan W, Gradoudas, Evangelos S, Hasan, Tayyaba, and Schmidt-Erfurth, Ursula. Use Of Green Porphyrinsto Treat Neovasculature In The Eyes.  United States: N. p., 1998. 
        Web.

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                    Levy, Julia, Miller, Joan W, Gradoudas, Evangelos S, Hasan, Tayyaba, & Schmidt-Erfurth, Ursula. Use Of Green Porphyrinsto Treat Neovasculature In The Eyes.  United States.

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                    Levy, Julia, Miller, Joan W, Gradoudas, Evangelos S, Hasan, Tayyaba, and Schmidt-Erfurth, Ursula. Tue .  
        "Use Of Green Porphyrinsto Treat Neovasculature In The Eyes".  United States.  https://www.osti.gov/servlets/purl/879252.

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@article{osti_879252,

  title        = {Use Of Green Porphyrinsto Treat Neovasculature In The Eyes},

  author       = {Levy, Julia and Miller, Joan W and Gradoudas, Evangelos S and Hasan, Tayyaba and Schmidt-Erfurth, Ursula},

  abstractNote = {Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1998},

  month        = {8}

}

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Works referenced in this record:

Photodynamic Therapy of Experimental Choroidal Melanoma Using Lipoprotein-delivered Benzoporphyrin
journal, January 1994

Schmidt-Erfurth, Ursula; Bauman, Wendall; Gragoudas, Evangelos
Ophthalmology, Vol. 101, Issue 1
https://doi.org/10.1016/S0161-6420(13)31242-1

Efficient syntheses of new classes of regiochemically pure benzoporphyrin derivatives
journal, December 1993

Pandey, Ravindra K.; Jagerovic, Nadine; Ryan, Joseph M.
Bioorganic & Medicinal Chemistry Letters, Vol. 3, Issue 12
https://doi.org/10.1016/S0960-894X(01)80726-5

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Similar Records

Title: Use Of Green Porphyrinsto Treat Neovasculature In The Eyes

Abstract

Citation Formats

Photodynamic Therapy of Experimental Choroidal Melanoma Using Lipoprotein-delivered Benzoporphyrin journal, January 1994

Efficient syntheses of new classes of regiochemically pure benzoporphyrin derivatives journal, December 1993

Photodynamic Therapy of Experimental Choroidal Melanoma Using Lipoprotein-delivered Benzoporphyrin
journal, January 1994

Efficient syntheses of new classes of regiochemically pure benzoporphyrin derivatives
journal, December 1993