Position Sequencing By Hybridization

Vazquez, Michael L; Mueller, Richard A; Talley, John J; Getman, Daniel; DeCrescenzo, Gary A; Freskos, John N

Title: Position Sequencing By Hybridization

Abstract

Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

Inventors:

Vazquez, Michael L ^[1]; Mueller, Richard A ^[2]; Talley, John J ^[3]; Getman, Daniel ^[4]; DeCrescenzo, Gary A ^[5]; Freskos, John N ^[6]

Gurnee, IL
Glencoe, IL
St. Louis, MO
Chesterfield, MO
St. Peters, MO
Clayton, MO

Issue Date:: 1995-10-31

Research Org.:: Boston University

OSTI Identifier:: 879209

Patent Number(s):: 5463104

Application Number:: 08/110912

Assignee:: G. D. Searle & Co. (Skokie, IL)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/381 - having five-membered rings

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C311/29 - having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/195 - having an amino group
A61K31/5375 - 1,4-Oxazines, e.g. morpholine

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C311/18 - to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/12 - Antivirals

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/4406 - only substituted in position 3, e.g. zimeldine
A61K31/18 - Sulfonamides

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C311/05 - to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/18 - for HIV

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/4409 - only substituted in position 4, e.g. isoniazid, iproniazid
A61K31/197 - the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid

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DOE Contract Number:: FG02-93ER61609

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Citation Formats


                    Vazquez, Michael L, Mueller, Richard A, Talley, John J, Getman, Daniel, DeCrescenzo, Gary A, and Freskos, John N. Position Sequencing By Hybridization.  United States: N. p., 1995. 
        Web.

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                    Vazquez, Michael L, Mueller, Richard A, Talley, John J, Getman, Daniel, DeCrescenzo, Gary A, & Freskos, John N. Position Sequencing By Hybridization.  United States.

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                    Vazquez, Michael L, Mueller, Richard A, Talley, John J, Getman, Daniel, DeCrescenzo, Gary A, and Freskos, John N. Tue .  
        "Position Sequencing By Hybridization".  United States.  https://www.osti.gov/servlets/purl/879209.

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@article{osti_879209,

  title        = {Position Sequencing By Hybridization},

  author       = {Vazquez, Michael L and Mueller, Richard A and Talley, John J and Getman, Daniel and DeCrescenzo, Gary A and Freskos, John N},

  abstractNote = {Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1995},

  month        = {10}

}

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Works referenced in this record:

A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation
journal, January 1990

McQuade, T.; Tomasselli, A.; Liu, L.
Science, Vol. 247, Issue 4941
https://doi.org/10.1126/science.2405486

Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease
journal, August 1990

Erickson, J.; Neidhart, D.; VanDrie, J.
Science, Vol. 249, Issue 4968
https://doi.org/10.1126/science.2200122

Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues
journal, January 1990

Meek, Thomas D.; Lambert, Dennis M.; Dreyer, Geoffrey B.
Nature, Vol. 343, Issue 6253
https://doi.org/10.1038/343090a0

Ro-31-8959/003
journal, January 1991

Martin, J. A.
Drugs of the Future, Vol. 16, Issue 3
https://doi.org/10.1358/dof.1991.016.03.132610

Rational design of peptide-based HIV proteinase inhibitors
journal, April 1990

Roberts, N.; Martin, J.; Kinchington, D.
Science, Vol. 248, Issue 4953
https://doi.org/10.1126/science.2183354

Novel renin inhibitors containing analogs of statine retro-inverted at the C-termini. Specificity at the P2 histidine site
journal, July 1987

Rosenberg, Saul H.; Plattner, Jacob J.; Woods, Keith W.
Journal of Medicinal Chemistry, Vol. 30, Issue 7
https://doi.org/10.1021/jm00390a018

Sequence specificity of retroviral proteases
journal, August 1987

Pear, Laurence H.; Taylo, William R.
Nature, Vol. 328, Issue 6130
https://doi.org/10.1038/328482b0

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Similar Records

Title: Position Sequencing By Hybridization

Abstract

Citation Formats

A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation journal, January 1990

Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease journal, August 1990

Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues journal, January 1990

Ro-31-8959/003 journal, January 1991

Rational design of peptide-based HIV proteinase inhibitors journal, April 1990

Novel renin inhibitors containing analogs of statine retro-inverted at the C-termini. Specificity at the P2 histidine site journal, July 1987

Sequence specificity of retroviral proteases journal, August 1987

A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation
journal, January 1990

Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease
journal, August 1990

Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues
journal, January 1990

Ro-31-8959/003
journal, January 1991

Rational design of peptide-based HIV proteinase inhibitors
journal, April 1990

Novel renin inhibitors containing analogs of statine retro-inverted at the C-termini. Specificity at the P2 histidine site
journal, July 1987

Sequence specificity of retroviral proteases
journal, August 1987