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Title: Samarium-145 and its use as a radiation source

Abstract

The present invention covers a new radiation source, samarium-145, with radiation energies slightly above those of I-125 and a half-life of 340 days. The samarium-145 source is produced by neutron irradiation of SM-144. This new source is useful as the implanted radiation source in photon activation therapy of malignant tumors to activate the stable I-127 contained in the IdUrd accumulated in the tumor, causing radiation sensitization and Auger cascades that irreperably damage the tumor cells. This new source is also useful as a brachytherapy source.

Inventors:
 [1];  [2];  [3]
  1. (Setauket, NY)
  2. (Plainview, NY)
  3. (Great Neck, NY)
Issue Date:
Research Org.:
ASSOC UNIVERSITIES INC
OSTI Identifier:
875239
Patent Number(s):
H669
Assignee:
United States of America as represented by United States (Washington, DC) BNL
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
samarium-145; radiation; source; covers; energies; slightly; i-125; half-life; 340; days; produced; neutron; irradiation; sm-144; useful; implanted; photon; activation; therapy; malignant; tumors; activate; stable; i-127; contained; idurd; accumulated; tumor; causing; sensitization; auger; cascades; irreperably; damage; cells; brachytherapy; neutron irradiation; radiation source; tumor cells; radiation energies; malignant tumors; /424/

Citation Formats

Fairchild, Ralph G., Laster, Brenda H., and Packer, Samuel. Samarium-145 and its use as a radiation source. United States: N. p., 1989. Web.
Fairchild, Ralph G., Laster, Brenda H., & Packer, Samuel. Samarium-145 and its use as a radiation source. United States.
Fairchild, Ralph G., Laster, Brenda H., and Packer, Samuel. Sun . "Samarium-145 and its use as a radiation source". United States. https://www.osti.gov/servlets/purl/875239.
@article{osti_875239,
title = {Samarium-145 and its use as a radiation source},
author = {Fairchild, Ralph G. and Laster, Brenda H. and Packer, Samuel},
abstractNote = {The present invention covers a new radiation source, samarium-145, with radiation energies slightly above those of I-125 and a half-life of 340 days. The samarium-145 source is produced by neutron irradiation of SM-144. This new source is useful as the implanted radiation source in photon activation therapy of malignant tumors to activate the stable I-127 contained in the IdUrd accumulated in the tumor, causing radiation sensitization and Auger cascades that irreperably damage the tumor cells. This new source is also useful as a brachytherapy source.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1989},
month = {1}
}

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