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Title: Boron uptake in tumors, cerebrum and blood from [10B]NA4B24H22S2

Abstract

A stable boronated (.sup.10 B-labeled) compound, sodium mercaptoundecahydrododecaborate is infused in the form of the disulfide dimer, [.sup.10 B]Na.sub.4 B.sub.24 H.sub.22 S.sub.2, at a dose of about 200 .mu.g .sup.10 B per gm body weight. The infusion is performed into the blood or peritoneal cavity of the patient slowly over a period of many days, perhaps one week or more, at the rate of roughly 1 .mu.g .sup.10 B per gm body weight per hour. Use of this particular boronated dimer in the manner or similarly to the manner so described permits radiotherapeutically effective amounts of boron to accumulate in tumors to be treated by boron neutron capture radiation therapy and also permits sufficient retention of boron in tumor after the cessation of the slow infusion, so as to allow the blood concentration of .sup.10 B to drop or to be reduced artificially to a radiotherapeutically effective level, less than one-half of the concentration of .sup.10 B in the tumor.

Inventors:
 [1];  [2];  [3]
  1. (Bayside, NY)
  2. (Patchogue, NY)
  3. (Setauket, NY)
Issue Date:
Research Org.:
ASSOC UNIVERSITIES INC
OSTI Identifier:
875212
Patent Number(s):
H505
Assignee:
United States of America as represented by United States (Washington, DC) BNL
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
boron; uptake; tumors; cerebrum; blood; 10b; na4b24h22s2; stable; boronated; 10; b-labeled; compound; sodium; mercaptoundecahydrododecaborate; infused; form; disulfide; dimer; na; 24; 22; dose; 200; gm; weight; infusion; performed; peritoneal; cavity; patient; slowly; period; days; week; rate; roughly; hour; particular; manner; similarly; described; permits; radiotherapeutically; effective; amounts; accumulate; treated; neutron; capture; radiation; therapy; sufficient; retention; tumor; cessation; slow; allow; concentration; drop; reduced; artificially; level; one-half; effective amount; neutron capture; boron neutron; radiation therapy; therapeutically effective; particular boron; /424/

Citation Formats

Slatkin, Daniel N., Micca, Peggy L., and Fairchild, Ralph G. Boron uptake in tumors, cerebrum and blood from [10B]NA4B24H22S2. United States: N. p., 1988. Web.
Slatkin, Daniel N., Micca, Peggy L., & Fairchild, Ralph G. Boron uptake in tumors, cerebrum and blood from [10B]NA4B24H22S2. United States.
Slatkin, Daniel N., Micca, Peggy L., and Fairchild, Ralph G. Fri . "Boron uptake in tumors, cerebrum and blood from [10B]NA4B24H22S2". United States. https://www.osti.gov/servlets/purl/875212.
@article{osti_875212,
title = {Boron uptake in tumors, cerebrum and blood from [10B]NA4B24H22S2},
author = {Slatkin, Daniel N. and Micca, Peggy L. and Fairchild, Ralph G.},
abstractNote = {A stable boronated (.sup.10 B-labeled) compound, sodium mercaptoundecahydrododecaborate is infused in the form of the disulfide dimer, [.sup.10 B]Na.sub.4 B.sub.24 H.sub.22 S.sub.2, at a dose of about 200 .mu.g .sup.10 B per gm body weight. The infusion is performed into the blood or peritoneal cavity of the patient slowly over a period of many days, perhaps one week or more, at the rate of roughly 1 .mu.g .sup.10 B per gm body weight per hour. Use of this particular boronated dimer in the manner or similarly to the manner so described permits radiotherapeutically effective amounts of boron to accumulate in tumors to be treated by boron neutron capture radiation therapy and also permits sufficient retention of boron in tumor after the cessation of the slow infusion, so as to allow the blood concentration of .sup.10 B to drop or to be reduced artificially to a radiotherapeutically effective level, less than one-half of the concentration of .sup.10 B in the tumor.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1988},
month = {1}
}

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