No-carrier-added (18F)-N-methylspiroperidol

Shiue, Chyng-Yann; Fowler, Joanna S; Wolf, Alfred P

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Title: No-carrier-added (18F)-N-methylspiroperidol

Abstract

There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [.sup.18 F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [.sup.18 F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.

Inventors:

Shiue, Chyng-Yann ^[1]; Fowler, Joanna S ^[2]; Wolf, Alfred P ^[3]

East Setauket, NY
Bellport, NY
Setauket, NY

Issue Date:: 1993-01-01

Research Org.:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 875158

Patent Number(s):: H001209

Application Number:: 06/784149

Assignee:: United States of America as represented by United States (Washington, DC)

DOE Contract Number:: AC02-76CH00016

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: no-carrier-added; disclosed; radioligand; labeled; positron; emitting; radionuclide; suitable; dynamic; study; living; humans; emission; transaxial; tomography; exhibiting; extremely; affinity; receptors; provides; enhanced; uptake; retention; brain; concomitant; reduced; radiation; burden; characteristics; combine; disease; additionally; synthetic; procedure; material; positron emission; provides enhanced; dopamine receptor; transaxial tomography; emission transaxial; emitting radionuclide; dynamic study; living human; statutory invention registration; /424/999/

Citation Formats


                    Shiue, Chyng-Yann, Fowler, Joanna S, and Wolf, Alfred P. No-carrier-added (18F)-N-methylspiroperidol.  United States: N. p., 1993. 
        Web.

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                    Shiue, Chyng-Yann, Fowler, Joanna S, & Wolf, Alfred P. No-carrier-added (18F)-N-methylspiroperidol.  United States.

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                    Shiue, Chyng-Yann, Fowler, Joanna S, and Wolf, Alfred P. Fri .  
        "No-carrier-added (18F)-N-methylspiroperidol".  United States.  https://www.osti.gov/servlets/purl/875158.

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@article{osti_875158,

  title        = {No-carrier-added (18F)-N-methylspiroperidol},

  author       = {Shiue, Chyng-Yann and Fowler, Joanna S and Wolf, Alfred P},

  abstractNote = {There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [.sup.18 F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [.sup.18 F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1993},

  month        = {1}

}

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Works referenced in this record:

Imaging dopamine receptors in the human brain by positron tomography
journal, September 1983

Wagner, H.; Burns, H.; Dannals, R.
Science, Vol. 221, Issue 4617
https://doi.org/10.1126/science.6604315

Preliminary studies with [18F]haloperidol: a radioligand for in vivo studies of the dopamine receptors
journal, June 1980

Tewson, T. J.; Raichle, M. E.; Welch, M. J.
Brain Research, Vol. 192, Issue 1
https://doi.org/10.1016/0006-8993(80)91032-X

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No-carrier-added (18F)-N-methylspiroperidol

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Similar Records

Title: No-carrier-added (18F)-N-methylspiroperidol

Abstract

Citation Formats

Imaging dopamine receptors in the human brain by positron tomography journal, September 1983

Preliminary studies with [18F]haloperidol: a radioligand for in vivo studies of the dopamine receptors journal, June 1980

Imaging dopamine receptors in the human brain by positron tomography
journal, September 1983

Preliminary studies with [18F]haloperidol: a radioligand for in vivo studies of the dopamine receptors
journal, June 1980