No-carrier-added (18F)-N-methylspiroperidol
Abstract
There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [.sup.18 F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [.sup.18 F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.
- Inventors:
-
- East Setauket, NY
- Bellport, NY
- Setauket, NY
- Issue Date:
- Research Org.:
- Associated Universities, Inc., Upton, NY (United States)
- OSTI Identifier:
- 875158
- Patent Number(s):
- H1209
- Assignee:
- United States of America as represented by United States (Washington, DC)
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- no-carrier-added; 18f; -n-methylspiroperidol; disclosed; radioligand; labeled; positron; emitting; radionuclide; suitable; dynamic; study; living; humans; emission; transaxial; tomography; 18; exhibiting; extremely; affinity; dopamine; receptors; provides; enhanced; uptake; retention; brain; concomitant; reduced; radiation; burden; characteristics; combine; provide; superior; radioligands; mapping; normal; disease; additionally; synthetic; procedure; material; positron emission; provides enhanced; dopamine receptor; transaxial tomography; emission transaxial; emitting radionuclide; dynamic study; living human; living humans; /424/999/
Citation Formats
Shiue, Chyng-Yann, Fowler, Joanna S, and Wolf, Alfred P. No-carrier-added (18F)-N-methylspiroperidol. United States: N. p., 1993.
Web.
Shiue, Chyng-Yann, Fowler, Joanna S, & Wolf, Alfred P. No-carrier-added (18F)-N-methylspiroperidol. United States.
Shiue, Chyng-Yann, Fowler, Joanna S, and Wolf, Alfred P. Fri .
"No-carrier-added (18F)-N-methylspiroperidol". United States. https://www.osti.gov/servlets/purl/875158.
@article{osti_875158,
title = {No-carrier-added (18F)-N-methylspiroperidol},
author = {Shiue, Chyng-Yann and Fowler, Joanna S and Wolf, Alfred P},
abstractNote = {There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [.sup.18 F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [.sup.18 F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {1}
}
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