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Title: No-carrier-added (18F)-N-methylspiroperidol

Abstract

There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [.sup.18 F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [.sup.18 F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.

Inventors:
 [1];  [2];  [3]
  1. (East Setauket, NY)
  2. (Bellport, NY)
  3. (Setauket, NY)
Issue Date:
Research Org.:
ASSOC UNIVERSITIES INC
OSTI Identifier:
875158
Patent Number(s):
H1209
Assignee:
United States of America as represented by United States (Washington, DC) BNL
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
no-carrier-added; 18f; -n-methylspiroperidol; disclosed; radioligand; labeled; positron; emitting; radionuclide; suitable; dynamic; study; living; humans; emission; transaxial; tomography; 18; exhibiting; extremely; affinity; dopamine; receptors; provides; enhanced; uptake; retention; brain; concomitant; reduced; radiation; burden; characteristics; combine; provide; superior; radioligands; mapping; normal; disease; additionally; synthetic; procedure; material; positron emission; provides enhanced; dopamine receptor; transaxial tomography; emission transaxial; emitting radionuclide; dynamic study; living human; living humans; /424/999/

Citation Formats

Shiue, Chyng-Yann, Fowler, Joanna S., and Wolf, Alfred P. No-carrier-added (18F)-N-methylspiroperidol. United States: N. p., 1993. Web.
Shiue, Chyng-Yann, Fowler, Joanna S., & Wolf, Alfred P. No-carrier-added (18F)-N-methylspiroperidol. United States.
Shiue, Chyng-Yann, Fowler, Joanna S., and Wolf, Alfred P. Fri . "No-carrier-added (18F)-N-methylspiroperidol". United States. https://www.osti.gov/servlets/purl/875158.
@article{osti_875158,
title = {No-carrier-added (18F)-N-methylspiroperidol},
author = {Shiue, Chyng-Yann and Fowler, Joanna S. and Wolf, Alfred P.},
abstractNote = {There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [.sup.18 F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [.sup.18 F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {1}
}

Patent:

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