Title: Treatment of addiction and addiction-related behavior

Abstract

The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. The present invention also provides a method of treatment of cocaine, morphine, heroin, nicotine, amphetamine, methamphetamine, or ethanol addiction by treating a mammal with an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. In one embodiment, the method of the present invention includes administering to the mammal an effective amount of a composition which increases central nervous system GABA levels wherein the effective amount is sufficient to diminish, inhibit or eliminate behavior associated with craving or use of drugs of abuse. The composition includes GVG, gabapentin, valproic acid, progabide, gamma-hydroxybutyric acid, fengabine, cetylGABA, topiramate or tiagabine or a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof.

Inventors:

Dewey, Stephen L ^[1]; Brodie, Jonathan D ^[2]; Ashby, Jr., Charles R. ^[3]

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+ Show Inventor Affiliations

1. Manorville, NY
2. Cos Cob, CT
3. (Miller Place, NY)

Issue Date:

2003-01-01

Research Org.:

Brookhaven National Laboratory (BNL), Upton, NY (United States)

OSTI Identifier:

875138

Patent Number(s):

6541520

Assignee:

Brookhaven Science Associates (Upton, NY)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K31/00 - Medicinal preparations containing organic active ingredients
A61K31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone}
A61K31/16 - Amides, e.g. hydroxamic acids
A61K31/165 - having aromatic rings, e.g. colchicine, atenolol, progabide
A61K31/19 - Carboxylic acids, e.g. valproic acid
A61K31/195 - having an amino group
A61K31/197 - the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
A61K31/221 - with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
A61K31/35 - having six-membered rings with one oxygen as the only ring hetero atom
A61K31/4535 - containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P25/30 - for treating abuse or dependence
A61P25/32 - Alcohol-abuse
A61P25/34 - Tobacco-abuse
A61P25/36 - Opioid-abuse

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DOE Contract Number:  

AC02-98CH10886

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

treatment; addiction; addiction-related; behavior; provides; highly; efficient; method; treating; substance; changing; mammal; suffering; administering; effective; amount; gamma; vinylgaba; pharmaceutically; acceptable; salt; cocaine; morphine; heroin; nicotine; amphetamine; methamphetamine; ethanol; embodiment; composition; increases; central; nervous; gaba; levels; sufficient; diminish; inhibit; eliminate; associated; craving; drugs; abuse; gvg; gabapentin; valproic; acid; progabide; gamma-hydroxybutyric; fengabine; cetylgaba; topiramate; tiagabine; enantiomer; racemic; mixture; pharmaceutically acceptable; efficient method; /514/