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Title: Treatment of addiction and addiction-related behavior

Abstract

The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. The present invention also provides a method of treatment of cocaine, morphine, heroin, nicotine, amphetamine, methamphetamine, or ethanol addiction by treating a mammal with an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. In one embodiment, the method of the present invention includes administering to the mammal an effective amount of a composition which increases central nervous system GABA levels wherein the effective amount is sufficient to diminish, inhibit or eliminate behavior associated with craving or use of drugs of abuse. The composition includes GVG, gabapentin, valproic acid, progabide, gamma-hydroxybutyric acid, fengabine, cetylGABA, topiramate or tiagabine or a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof.

Inventors:
 [1];  [2];  [3]
  1. (Manorville, NY)
  2. (Cos Cob, CT)
  3. (Miller Place, NY)
Issue Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY
OSTI Identifier:
875138
Patent Number(s):
6541520
Assignee:
Brookhaven Science Associates (Upton, NY) BNL
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
treatment; addiction; addiction-related; behavior; provides; highly; efficient; method; treating; substance; changing; mammal; suffering; administering; effective; amount; gamma; vinylgaba; pharmaceutically; acceptable; salt; cocaine; morphine; heroin; nicotine; amphetamine; methamphetamine; ethanol; embodiment; composition; increases; central; nervous; gaba; levels; sufficient; diminish; inhibit; eliminate; associated; craving; drugs; abuse; gvg; gabapentin; valproic; acid; progabide; gamma-hydroxybutyric; fengabine; cetylgaba; topiramate; tiagabine; enantiomer; racemic; mixture; pharmaceutically acceptable; efficient method; /514/

Citation Formats

Dewey, Stephen L., Brodie, Jonathan D., and Ashby, Jr., Charles R. Treatment of addiction and addiction-related behavior. United States: N. p., 2003. Web.
Dewey, Stephen L., Brodie, Jonathan D., & Ashby, Jr., Charles R. Treatment of addiction and addiction-related behavior. United States.
Dewey, Stephen L., Brodie, Jonathan D., and Ashby, Jr., Charles R. Wed . "Treatment of addiction and addiction-related behavior". United States. https://www.osti.gov/servlets/purl/875138.
@article{osti_875138,
title = {Treatment of addiction and addiction-related behavior},
author = {Dewey, Stephen L. and Brodie, Jonathan D. and Ashby, Jr., Charles R.},
abstractNote = {The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. The present invention also provides a method of treatment of cocaine, morphine, heroin, nicotine, amphetamine, methamphetamine, or ethanol addiction by treating a mammal with an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. In one embodiment, the method of the present invention includes administering to the mammal an effective amount of a composition which increases central nervous system GABA levels wherein the effective amount is sufficient to diminish, inhibit or eliminate behavior associated with craving or use of drugs of abuse. The composition includes GVG, gabapentin, valproic acid, progabide, gamma-hydroxybutyric acid, fengabine, cetylGABA, topiramate or tiagabine or a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {1}
}

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