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Title: Microfabricated electrochemiluminescence cell for chemical reaction detection

Abstract

A detector cell for a silicon-based or non-silicon-based sleeve type chemical reaction chamber that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The detector cell is an electrochemiluminescence cell constructed of layers of silicon with a cover layer of glass, with spaced electrodes located intermediate various layers forming the cell. The cell includes a cavity formed therein and fluid inlets for directing reaction fluid therein. The reaction chamber and detector cell may be utilized in any chemical reaction system for synthesis or processing of organic, inorganic, or biochemical reactions, such as the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction, which are examples of a synthetic, thermal-cycling-based reaction. The ECL cell may also be used in synthesis instruments, particularly those for DNA amplification and synthesis.

Inventors:
 [1];  [2];  [2]
  1. (Berkeley, CA)
  2. (Davis, CA)
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
875055
Patent Number(s):
6521181
Assignee:
The Regents of the University of Calfornia (Oakland, CA) LLNL
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
microfabricated; electrochemiluminescence; cell; chemical; reaction; detection; detector; silicon-based; non-silicon-based; sleeve; type; chamber; combines; heaters; doped; polysilicon; heating; bulk; silicon; convection; cooling; constructed; layers; cover; layer; glass; spaced; electrodes; located; intermediate; forming; cavity; formed; fluid; inlets; directing; utilized; synthesis; processing; organic; inorganic; biochemical; reactions; polymerase; chain; pcr; andor; dna; ligase; examples; synthetic; thermal-cycling-based; ecl; instruments; amplification; reaction chamber; chemical reaction; bulk silicon; detector cell; /422/435/

Citation Formats

Northrup, M. Allen, Hsueh, Yun-Tai, and Smith, Rosemary L. Microfabricated electrochemiluminescence cell for chemical reaction detection. United States: N. p., 2003. Web.
Northrup, M. Allen, Hsueh, Yun-Tai, & Smith, Rosemary L. Microfabricated electrochemiluminescence cell for chemical reaction detection. United States.
Northrup, M. Allen, Hsueh, Yun-Tai, and Smith, Rosemary L. Wed . "Microfabricated electrochemiluminescence cell for chemical reaction detection". United States. https://www.osti.gov/servlets/purl/875055.
@article{osti_875055,
title = {Microfabricated electrochemiluminescence cell for chemical reaction detection},
author = {Northrup, M. Allen and Hsueh, Yun-Tai and Smith, Rosemary L.},
abstractNote = {A detector cell for a silicon-based or non-silicon-based sleeve type chemical reaction chamber that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The detector cell is an electrochemiluminescence cell constructed of layers of silicon with a cover layer of glass, with spaced electrodes located intermediate various layers forming the cell. The cell includes a cavity formed therein and fluid inlets for directing reaction fluid therein. The reaction chamber and detector cell may be utilized in any chemical reaction system for synthesis or processing of organic, inorganic, or biochemical reactions, such as the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction, which are examples of a synthetic, thermal-cycling-based reaction. The ECL cell may also be used in synthesis instruments, particularly those for DNA amplification and synthesis.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {1}
}

Patent:

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