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Title: Methods for boron delivery to mammalian tissue

Abstract

Boron neutron capture therapy can be used to destroy tumors. This treatment modality is enhanced by delivering compounds to the tumor site where the compounds have high concentrations of boron, the boron compounds being encapsulated in the bilayer of a liposome or in the bilayer as well as the internal space of the liposomes. Preferred compounds, include carborane units with multiple boron atoms within the carborane cage structure. Liposomes with increased tumor specificity may also be used.

Inventors:
 [1];  [2];  [2]
  1. Encino, CA
  2. Los Angeles, CA
Issue Date:
Research Org.:
Univ. of California (United States)
OSTI Identifier:
875036
Patent Number(s):
6517808
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
FG03-95ER61975
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
methods; boron; delivery; mammalian; tissue; neutron; capture; therapy; destroy; tumors; treatment; modality; enhanced; delivering; compounds; tumor; site; concentrations; encapsulated; bilayer; liposome; internal; space; liposomes; carborane; units; multiple; atoms; cage; structure; increased; specificity; neutron capture; boron neutron; mammalian tissue; /424/

Citation Formats

Hawthorne, M Frederick, Feaks, Debra A, and Shelly, Kenneth J. Methods for boron delivery to mammalian tissue. United States: N. p., 2003. Web.
Hawthorne, M Frederick, Feaks, Debra A, & Shelly, Kenneth J. Methods for boron delivery to mammalian tissue. United States.
Hawthorne, M Frederick, Feaks, Debra A, and Shelly, Kenneth J. Wed . "Methods for boron delivery to mammalian tissue". United States. https://www.osti.gov/servlets/purl/875036.
@article{osti_875036,
title = {Methods for boron delivery to mammalian tissue},
author = {Hawthorne, M Frederick and Feaks, Debra A and Shelly, Kenneth J},
abstractNote = {Boron neutron capture therapy can be used to destroy tumors. This treatment modality is enhanced by delivering compounds to the tumor site where the compounds have high concentrations of boron, the boron compounds being encapsulated in the bilayer of a liposome or in the bilayer as well as the internal space of the liposomes. Preferred compounds, include carborane units with multiple boron atoms within the carborane cage structure. Liposomes with increased tumor specificity may also be used.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {1}
}

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Works referenced in this record:

Model studies directed toward the boron neutron-capture therapy of cancer: boron delivery to murine tumors with liposomes.
journal, October 1992

  • Shelly, K.; Feakes, D. A.; Hawthorne, M. F.
  • Proceedings of the National Academy of Sciences, Vol. 89, Issue 19
  • DOI: 10.1073/pnas.89.19.9039