Methods for boron delivery to mammalian tissue
Abstract
Boron neutron capture therapy can be used to destroy tumors. This treatment modality is enhanced by delivering compounds to the tumor site where the compounds have high concentrations of boron, the boron compounds being encapsulated in the bilayer of a liposome or in the bilayer as well as the internal space of the liposomes. Preferred compounds, include carborane units with multiple boron atoms within the carborane cage structure. Liposomes with increased tumor specificity may also be used.
- Inventors:
-
- (Encino, CA)
- (Los Angeles, CA)
- Issue Date:
- Research Org.:
- University of California
- OSTI Identifier:
- 875036
- Patent Number(s):
- 6517808
- Assignee:
- The Regents of the University of California (Oakland, CA) OAK
- DOE Contract Number:
- FG03-95ER61975
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- methods; boron; delivery; mammalian; tissue; neutron; capture; therapy; destroy; tumors; treatment; modality; enhanced; delivering; compounds; tumor; site; concentrations; encapsulated; bilayer; liposome; internal; space; liposomes; carborane; units; multiple; atoms; cage; structure; increased; specificity; neutron capture; boron neutron; mammalian tissue; /424/
Citation Formats
Hawthorne, M. Frederick, Feaks, Debra A., and Shelly, Kenneth J. Methods for boron delivery to mammalian tissue. United States: N. p., 2003.
Web.
Hawthorne, M. Frederick, Feaks, Debra A., & Shelly, Kenneth J. Methods for boron delivery to mammalian tissue. United States.
Hawthorne, M. Frederick, Feaks, Debra A., and Shelly, Kenneth J. Wed .
"Methods for boron delivery to mammalian tissue". United States. https://www.osti.gov/servlets/purl/875036.
@article{osti_875036,
title = {Methods for boron delivery to mammalian tissue},
author = {Hawthorne, M. Frederick and Feaks, Debra A. and Shelly, Kenneth J.},
abstractNote = {Boron neutron capture therapy can be used to destroy tumors. This treatment modality is enhanced by delivering compounds to the tumor site where the compounds have high concentrations of boron, the boron compounds being encapsulated in the bilayer of a liposome or in the bilayer as well as the internal space of the liposomes. Preferred compounds, include carborane units with multiple boron atoms within the carborane cage structure. Liposomes with increased tumor specificity may also be used.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {1}
}
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