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Title: Phthalamide lanthanide complexes for use as luminescent markers

Abstract

The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.

Inventors:
 [1];  [1];  [2];  [1]
  1. Berkeley, CA
  2. Boston, MA
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
875026
Patent Number(s):
6515113
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
phthalamide; lanthanide; complexes; luminescent; markers; provides; metal; chelates; comprising; series; complexing; agent; phthalamidyl; moiety; provided; probes; incorporating; ligands; methods; utilizing; complexing agent; metal chelate; lanthanide metal; /999/435/436/

Citation Formats

Raymond, Kenneth N, Petoud, Stephane, Cohen, Seth M, and Xu, Jide. Phthalamide lanthanide complexes for use as luminescent markers. United States: N. p., 2003. Web.
Raymond, Kenneth N, Petoud, Stephane, Cohen, Seth M, & Xu, Jide. Phthalamide lanthanide complexes for use as luminescent markers. United States.
Raymond, Kenneth N, Petoud, Stephane, Cohen, Seth M, and Xu, Jide. Wed . "Phthalamide lanthanide complexes for use as luminescent markers". United States. https://www.osti.gov/servlets/purl/875026.
@article{osti_875026,
title = {Phthalamide lanthanide complexes for use as luminescent markers},
author = {Raymond, Kenneth N and Petoud, Stephane and Cohen, Seth M and Xu, Jide},
abstractNote = {The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {1}
}

Patent:

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Works referenced in this record:

Time-resolved detection of lanthanide luminescence for ultrasensitive bioanalytical assays
journal, January 1995

  • Gudgin Dickson, Eva F.; Pollak, Alfred; Diamandis, Eleftherios P.
  • Journal of Photochemistry and Photobiology B: Biology, Vol. 27, Issue 1, p. 3-19
  • DOI: 10.1016/1011-1344(94)07086-4

Development of luminescent lanthanide chelate labels for diagnostic assays
journal, March 1997

  • Hemmilä, Ilkka; Mukkala, Veli-Matti; Takalo, Harri
  • Journal of Alloys and Compounds, Vol. 249, Issue 1-2, p. 158-162
  • DOI: 10.1016/S0925-8388(96)02834-4

Water-Soluble Neutral Calix[4]arene−Lanthanide Complexes: Synthesis and Luminescence Properties
journal, June 1997

  • Steemers, Frank J.; Meuris, Hans G.; Verboom, Willem
  • The Journal of Organic Chemistry, Vol. 62, Issue 13, p. 4229-4235
  • DOI: 10.1021/jo970132j

Towards materials with planned properties: dinuclear f-f helicates and d-f non-covalent podates based on benzimidazole-pyridine binding units
journal, March 1997

  • Bünzli, Jean-Claude G.; Petoud, Stéphane; Piguet, Claude
  • Journal of Alloys and Compounds, Vol. 249, Issue 1-2, p. 14-24
  • DOI: 10.1016/S0925-8388(96)02519-4

Lifetime- and Color-Tailored Fluorophores in the Micro- to Millisecond Time Regime
journal, February 2000

  • Chen, Jiyan; Selvin, Paul R.
  • Journal of the American Chemical Society, Vol. 122, Issue 4, p. 657-660
  • DOI: 10.1021/ja9913986

Time-resolved fluorescence of a new europium-chelate complex: demonstration of highly sensitive detection of protein and DNA samples
journal, November 1993

  • Saha, Ashis K.; Kross, Kathryn; Kloszewski, Edmond D.
  • Journal of the American Chemical Society, Vol. 115, Issue 23, p. 11032-11033
  • DOI: 10.1021/ja00076a088

Spectroscopic properties and design of highly luminescent lanthanide coordination complexes
journal, January 2000

  • de Sa, G. F.; Malta, O. L.; de Mello Donega, C.
  • Coordination Chemistry Reviews, Vol. 196, Issue 1, p. 165-195
  • DOI: 10.1016/S0010-8545(99)00054-5

Comparative study of fluorescent ternary terbium complexes. Application in enzyme amplified fluorimetric immunoassay for α-fetoprotein
journal, December 1996

  • Veiopoulou, Christina J.; Lianidou, Evriklia S.; Ioannou, Pinelopi C.
  • Analytica Chimica Acta, Vol. 335, Issue 1-2, p. 177-184
  • DOI: 10.1016/S0003-2670(96)00375-3

Luminescence and structure of europium compounds
journal, January 2000

  • Vicentini, G.; Zinner, L. B.; Zukerman-Schpector, J.
  • Coordination Chemistry Reviews, Vol. 196, Issue 1, p. 353-382
  • DOI: 10.1016/S0010-8545(99)00220-9

Time-Resolved Fluorescence of Lanthanide Probes and Applications in Biotechnology
journal, January 1987

  • Soini, Erkki; Lövgren, Timo; Reimer, Charles B.
  • C R C Critical Reviews in Analytical Chemistry, Vol. 18, Issue 2, p. 105-154
  • DOI: 10.1080/10408348708542802

Homogeneous Time-Resolved Il-2–Il-2rα Assay Using Fluorescence Resonance Energy Transfer
journal, July 1998

  • Stenroos, Karolina; Hurskainen, Pertti; Eriksson, Susann
  • Cytokine, Vol. 10, Issue 7
  • DOI: 10.1006/cyto.1997.0321