Agouti polynucleotide compositions and methods of use

Title: Agouti polynucleotide compositions and methods of use

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Abstract

Disclosed are methods and compositions comprising novel agouti polypeptides and the polynucleotides which encode them. Also disclosed are DNA segments encoding these proteins derived from human and murine cell lines, and the use of these polynucleotides and polypeptides in a variety of diagnostic and therapeutic applications. Methods, compositions, kits, and devices are also provided for identifying compounds which are inhibitors of agouti activity, and for altering fatty acid synthetase activity and intracellular calcium levels in transformed cells.

Inventors:

Woychik, Richard P. ^[1]; Bultman, Scott J. ^[2]; Michaud, Edward J. ^[3]

(Orinda, CA)
(Lakewood, OH)
(Kingston, TN)

Issue Date:: 2003-02-04

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN

OSTI Identifier:: 875024

Patent Number(s):: 6514747

Application Number:: 09/781,811

Assignee:: UT-Battelle, LLC (Oak Ridge, TN) ORNL

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: agouti; polynucleotide; compositions; methods; disclosed; comprising; novel; polypeptides; polynucleotides; encode; dna; segments; encoding; proteins; derived; human; murine; cell; lines; variety; diagnostic; therapeutic; applications; kits; devices; provided; identifying; compounds; inhibitors; activity; altering; fatty; acid; synthetase; intracellular; calcium; levels; transformed; cells; fatty acid; /435/999/

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                    Woychik, Richard P., Bultman, Scott J., and Michaud, Edward J. Agouti polynucleotide compositions and methods of use.  United States: N. p., 2003. 
        Web.

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                    Woychik, Richard P., Bultman, Scott J., & Michaud, Edward J. Agouti polynucleotide compositions and methods of use.  United States.

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                    Woychik, Richard P., Bultman, Scott J., and Michaud, Edward J. Tue .  
        "Agouti polynucleotide compositions and methods of use".  United States.  https://www.osti.gov/servlets/purl/875024.

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@article{osti_875024,

  title        = {Agouti polynucleotide compositions and methods of use},

  author       = {Woychik, Richard P. and Bultman, Scott J. and Michaud, Edward J.},

  abstractNote = {Disclosed are methods and compositions comprising novel agouti polypeptides and the polynucleotides which encode them. Also disclosed are DNA segments encoding these proteins derived from human and murine cell lines, and the use of these polynucleotides and polypeptides in a variety of diagnostic and therapeutic applications. Methods, compositions, kits, and devices are also provided for identifying compounds which are inhibitors of agouti activity, and for altering fatty acid synthetase activity and intracellular calcium levels in transformed cells.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2003},

  month        = {2}

}

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