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Title: Transgenic rabbit that expresses a functional human lipoprotein (a)

Abstract

A transgenic rabbit which has in its genomic DNA sequences that encode apolipoprotein (a) and apolipoprotein B polypeptides which are capable of combining to produce lipoprotein (a), a process for creating such a rabbit, and the use of the rabbit to identify compounds which are effective in the treatment of human diseases which are associated with, induced and/or exacerbated by Lp(a) expression.

Inventors:
 [1];  [2];  [3];  [4];  [5];  [6];  [7];  [8]
  1. (Thiais, FR)
  2. (Paris, FR)
  3. (Aubervilliers, FR)
  4. (Saint Maur, FR)
  5. (Buc, FR)
  6. (Versailles, FR)
  7. (Berkeley, CA)
  8. (Oakland, CA)
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
OSTI Identifier:
875011
Patent Number(s):
6512161
Assignee:
Aventis Pharmaceuticals, Inc. (Bridgewater, NJ) LBNL
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
transgenic; rabbit; expresses; functional; human; lipoprotein; genomic; dna; sequences; encode; apolipoprotein; polypeptides; capable; combining; produce; process; creating; identify; compounds; effective; treatment; diseases; associated; induced; andor; exacerbated; lpa; expression; dna sequence; /800/

Citation Formats

Rouy, Didier, Duverger, Nicolas, Emmanuel, Florence, Denefle, Patrice, Houdebine, Louis-Marie, Viglietta, Celine, Rubin, Edward M., and Hughes, Steven D. Transgenic rabbit that expresses a functional human lipoprotein (a). United States: N. p., 2003. Web.
Rouy, Didier, Duverger, Nicolas, Emmanuel, Florence, Denefle, Patrice, Houdebine, Louis-Marie, Viglietta, Celine, Rubin, Edward M., & Hughes, Steven D. Transgenic rabbit that expresses a functional human lipoprotein (a). United States.
Rouy, Didier, Duverger, Nicolas, Emmanuel, Florence, Denefle, Patrice, Houdebine, Louis-Marie, Viglietta, Celine, Rubin, Edward M., and Hughes, Steven D. Wed . "Transgenic rabbit that expresses a functional human lipoprotein (a)". United States. https://www.osti.gov/servlets/purl/875011.
@article{osti_875011,
title = {Transgenic rabbit that expresses a functional human lipoprotein (a)},
author = {Rouy, Didier and Duverger, Nicolas and Emmanuel, Florence and Denefle, Patrice and Houdebine, Louis-Marie and Viglietta, Celine and Rubin, Edward M. and Hughes, Steven D.},
abstractNote = {A transgenic rabbit which has in its genomic DNA sequences that encode apolipoprotein (a) and apolipoprotein B polypeptides which are capable of combining to produce lipoprotein (a), a process for creating such a rabbit, and the use of the rabbit to identify compounds which are effective in the treatment of human diseases which are associated with, induced and/or exacerbated by Lp(a) expression.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {1}
}

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