skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Transgenic rabbit that expresses a functional human lipoprotein (a)

Abstract

A transgenic rabbit which has in its genomic DNA sequences that encode apolipoprotein (a) and apolipoprotein B polypeptides which are capable of combining to produce lipoprotein (a), a process for creating such a rabbit, and the use of the rabbit to identify compounds which are effective in the treatment of human diseases which are associated with, induced and/or exacerbated by Lp(a) expression.

Inventors:
 [1];  [2];  [3];  [4];  [5];  [6];  [7];  [8]
  1. Thiais, FR
  2. Paris, FR
  3. Aubervilliers, FR
  4. Saint Maur, FR
  5. Buc, FR
  6. Versailles, FR
  7. Berkeley, CA
  8. Oakland, CA
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
875011
Patent Number(s):
6512161
Assignee:
Aventis Pharmaceuticals, Inc. (Bridgewater, NJ)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
transgenic; rabbit; expresses; functional; human; lipoprotein; genomic; dna; sequences; encode; apolipoprotein; polypeptides; capable; combining; produce; process; creating; identify; compounds; effective; treatment; diseases; associated; induced; andor; exacerbated; lpa; expression; dna sequence; /800/

Citation Formats

Rouy, Didier, Duverger, Nicolas, Emmanuel, Florence, Denefle, Patrice, Houdebine, Louis-Marie, Viglietta, Celine, Rubin, Edward M, and Hughes, Steven D. Transgenic rabbit that expresses a functional human lipoprotein (a). United States: N. p., 2003. Web.
Rouy, Didier, Duverger, Nicolas, Emmanuel, Florence, Denefle, Patrice, Houdebine, Louis-Marie, Viglietta, Celine, Rubin, Edward M, & Hughes, Steven D. Transgenic rabbit that expresses a functional human lipoprotein (a). United States.
Rouy, Didier, Duverger, Nicolas, Emmanuel, Florence, Denefle, Patrice, Houdebine, Louis-Marie, Viglietta, Celine, Rubin, Edward M, and Hughes, Steven D. Wed . "Transgenic rabbit that expresses a functional human lipoprotein (a)". United States. https://www.osti.gov/servlets/purl/875011.
@article{osti_875011,
title = {Transgenic rabbit that expresses a functional human lipoprotein (a)},
author = {Rouy, Didier and Duverger, Nicolas and Emmanuel, Florence and Denefle, Patrice and Houdebine, Louis-Marie and Viglietta, Celine and Rubin, Edward M and Hughes, Steven D},
abstractNote = {A transgenic rabbit which has in its genomic DNA sequences that encode apolipoprotein (a) and apolipoprotein B polypeptides which are capable of combining to produce lipoprotein (a), a process for creating such a rabbit, and the use of the rabbit to identify compounds which are effective in the treatment of human diseases which are associated with, induced and/or exacerbated by Lp(a) expression.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {1}
}

Patent:

Save / Share:

Works referenced in this record:

Gene Transfer of Cytidine Deaminase apoBEC-1 Lowers Lipoprotein(a) in Transgenic Mice and Induces Apolipoprotein B Editing in Rabbits
journal, January 1996


Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.
journal, May 1995


Regulating gene expression in transgenic animals
journal, October 1992


Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
journal, August 1970


Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5
journal, July 1977


Hereditary hyperlipidemia and atherosclerosis in the rabbit due to overproduction of lipoproteins. II. Preliminary report of arterial pathology.
journal, March 1987


The apolipoprotein(a) gene is regulated by sex hormones and acute–phase inducers in YAC transgenic mice
journal, April 1995


Environmental radiation (1-14)
journal, December 1999


Endothelial Derived Vasorelaxation Is Impaired in Human APO A-I Transgenic Rabbits
journal, December 1997


A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine
journal, September 1987


Inhibition of Atherosclerosis Development in Cholesterol-Fed Human Apolipoprotein A-I–Transgenic Rabbits
journal, August 1996


Germ-Line Transformation of Mice
journal, December 1986


Insertion of the bacterial gpt gene into the germ line of mice by retroviral infection.
journal, October 1985


A method for the preparative isolation and concentration of intact yeast artificial chromosomes
journal, January 1989


The mysteries of lipoprotein(a)
journal, November 1989


Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
journal, May 1984


Establishment in culture of pluripotential cells from mouse embryos
journal, July 1981


“Homology” in proteins and nucleic acids: A terminology muddle and a way out of it
journal, August 1987


Atherogenesis in transgenic mice expressing human apolipoprotein(a)
journal, December 1992


Defective and nondefective adenovirus vectors for expressing foreign genes in vitro and in vivo
journal, May 1991


Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
journal, September 1979


Mutagenesis of the human apolipoprotein B gene in a yeast artificial chromosome reveals the site of attachment for apolipoprotein(a).
journal, October 1995


The binding of animal low-density lipoproteins to human apolipoprotein(a)
journal, August 1995


Efficient insertion of genes into the mouse germ line via retroviral vectors.
journal, September 1985


[3] Comparative analysis of mammalian plasma lipoproteins
book, January 1986


Transgenesis by means of blastocyst-derived embryonic stem cell lines.
journal, December 1986


Human apoHpoprotetas AI, AII, CII and CIII. cDNA sequences and mRNA abundance
journal, January 1984


Apolipoprotein(a) Yeast Artificial Chromosome Transgenic Rabbits: LIPOPROTEIN(a) ASSEMBLY WITH HUMAN AND RABBIT APOLIPOPROTEIN B
journal, January 1998


Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a).
journal, December 1993


Expression of retroviral vectors in transgenic mice obtained by embryo infection.
journal, February 1987


Protein composition of Lp(a) lipoprotein from human plasma
journal, April 1983


Human Gene Therapy: The First Round
journal, August 1985


Transgenic Rabbits Expressing Human Apolipoprotein A-I in the Liver
journal, December 1996


Cloning of random-sequence oligodeoxynucleotides
journal, January 1986


Macrophage and smooth muscle cell proliferation in atherosclerotic lesions of WHHL and comparably hypercholesterolemic fat-fed rabbits.
journal, September 1990


Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector
journal, October 1986


Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag region.
journal, January 1987


Protein composition determines the anti-atherogenic properties of HDL in transgenic mice
journal, October 1993


Transgenic animals
journal, June 1988


Application of antisense technology to therapeutics
journal, June 1995


Lipoprotein (a) and coronary heart disease
journal, January 1995


Modifying the Mouse: Design and Desire
journal, May 1992


Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.
journal, July 1985


Lipoprotein(a) Assembly: Quantitative Assessment of the Role of Apo(a) Kringle IV Types 2-10 in Particle Formation
journal, December 1996


Apoproteins B and A-I and coronary artery disease in humans.
journal, March 1984


A potential animal model for Lesch–Nyhan syndrome through introduction of HPRT mutations into mice
journal, March 1987


Expression of human apolipoprotein B and assembly of lipoprotein(a) in transgenic mice.
journal, March 1994


Activation of transforming growth factor-β is inhibited in transgenic apolipoprotein(a) mice
journal, August 1994


De novo methylation and expression of retroviral genomes during mouse embryogenesis
journal, August 1982


Overexpression of Human Apolipoprotein B-100 in Transgenic Rabbits Results in Increased Levels of LDL and Decreased Levels of HDL
journal, November 1995


A Two-step Model for Lipoprotein(a) Formation
journal, June 1995


Gene Transfer with Retrovirus Vectors
book, January 1985