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Title: PCR thermocycler

Abstract

A sleeve-type silicon polymerase chain reaction (PCR) chamber or thermocycler having improved thermal performance. The silicon sleeve reaction chamber is improved in thermal performance by etched features therein that reduce thermal mass and increase the surface area of the sleeve for cooling. This improved thermal performance of the thermocycler enables an increase in speed and efficiency of the reaction chamber. The improvement is accomplished by providing grooves in the faces of the sleeve and a series of grooves on the interior surfaces that connect with grooves on the faces of the sleeve. The grooves can be anisotropically etched in the silicon sleeve simultaneously with formation of the chamber.

Inventors:
 [1];  [2]
  1. (Livermore, CA)
  2. (Danville, CA)
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
874979
Patent Number(s):
6503750
Assignee:
The Regents of the University of California (Oakland, CA) LLNL
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
pcr; thermocycler; sleeve-type; silicon; polymerase; chain; reaction; chamber; improved; thermal; performance; sleeve; etched; features; reduce; mass; increase; surface; cooling; enables; speed; efficiency; improvement; accomplished; providing; grooves; series; interior; surfaces; connect; anisotropically; simultaneously; formation; reaction chamber; interior surface; chain reaction; reduce thermal; thermal mass; thermal performance; /435/422/

Citation Formats

Benett, William J., and Richards, James B. PCR thermocycler. United States: N. p., 2003. Web.
Benett, William J., & Richards, James B. PCR thermocycler. United States.
Benett, William J., and Richards, James B. Wed . "PCR thermocycler". United States. https://www.osti.gov/servlets/purl/874979.
@article{osti_874979,
title = {PCR thermocycler},
author = {Benett, William J. and Richards, James B.},
abstractNote = {A sleeve-type silicon polymerase chain reaction (PCR) chamber or thermocycler having improved thermal performance. The silicon sleeve reaction chamber is improved in thermal performance by etched features therein that reduce thermal mass and increase the surface area of the sleeve for cooling. This improved thermal performance of the thermocycler enables an increase in speed and efficiency of the reaction chamber. The improvement is accomplished by providing grooves in the faces of the sleeve and a series of grooves on the interior surfaces that connect with grooves on the faces of the sleeve. The grooves can be anisotropically etched in the silicon sleeve simultaneously with formation of the chamber.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {1}
}

Patent:

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