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Title: Method for calibrating mass spectrometers

Abstract

A method whereby a mass spectra generated by a mass spectrometer is calibrated by shifting the parameters used by the spectrometer to assign masses to the spectra in a manner which reconciles the signal of ions within the spectra having equal mass but differing charge states, or by reconciling ions having known differences in mass to relative values consistent with those known differences. In this manner, the mass spectrometer is calibrated without the need for standards while allowing the generation of a highly accurate mass spectra by the instrument.

Inventors:
 [1];  [2];  [3];  [2];  [2]
  1. Benton City, WA
  2. Richland, WA
  3. Schwenksville, PA
Issue Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
874962
Patent Number(s):
6,498,340
Assignee:
Battelle Memorial Institute (Richland, WA) PNNL
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; calibrating; mass; spectrometers; spectra; generated; spectrometer; calibrated; shifting; parameters; masses; manner; reconciles; signal; equal; differing; charge; reconciling; differences; values; consistent; standards; allowing; generation; highly; accurate; instrument; mass spectrometer; /250/

Citation Formats

Anderson, Gordon A, Brands, Michael D, Bruce, James E, Pasa-Tolic, Ljiljana, and Smith, Richard D. Method for calibrating mass spectrometers. United States: N. p., 2002. Web.
Anderson, Gordon A, Brands, Michael D, Bruce, James E, Pasa-Tolic, Ljiljana, & Smith, Richard D. Method for calibrating mass spectrometers. United States.
Anderson, Gordon A, Brands, Michael D, Bruce, James E, Pasa-Tolic, Ljiljana, and Smith, Richard D. Tue . "Method for calibrating mass spectrometers". United States. https://www.osti.gov/servlets/purl/874962.
@article{osti_874962,
title = {Method for calibrating mass spectrometers},
author = {Anderson, Gordon A and Brands, Michael D and Bruce, James E and Pasa-Tolic, Ljiljana and Smith, Richard D},
abstractNote = {A method whereby a mass spectra generated by a mass spectrometer is calibrated by shifting the parameters used by the spectrometer to assign masses to the spectra in a manner which reconciles the signal of ions within the spectra having equal mass but differing charge states, or by reconciling ions having known differences in mass to relative values consistent with those known differences. In this manner, the mass spectrometer is calibrated without the need for standards while allowing the generation of a highly accurate mass spectra by the instrument.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {12}
}

Patent:

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