Method for calibrating mass spectrometers
Abstract
A method whereby a mass spectra generated by a mass spectrometer is calibrated by shifting the parameters used by the spectrometer to assign masses to the spectra in a manner which reconciles the signal of ions within the spectra having equal mass but differing charge states, or by reconciling ions having known differences in mass to relative values consistent with those known differences. In this manner, the mass spectrometer is calibrated without the need for standards while allowing the generation of a highly accurate mass spectra by the instrument.
- Inventors:
-
- Benton City, WA
- Richland, WA
- Schwenksville, PA
- Issue Date:
- Research Org.:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 874962
- Patent Number(s):
- 6,498,340
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- DOE Contract Number:
- AC06-76RL01830
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; calibrating; mass; spectrometers; spectra; generated; spectrometer; calibrated; shifting; parameters; masses; manner; reconciles; signal; equal; differing; charge; reconciling; differences; values; consistent; standards; allowing; generation; highly; accurate; instrument; mass spectrometer; /250/
Citation Formats
Anderson, Gordon A, Brands, Michael D, Bruce, James E, Pasa-Tolic, Ljiljana, and Smith, Richard D. Method for calibrating mass spectrometers. United States: N. p., 2002.
Web.
Anderson, Gordon A, Brands, Michael D, Bruce, James E, Pasa-Tolic, Ljiljana, & Smith, Richard D. Method for calibrating mass spectrometers. United States.
Anderson, Gordon A, Brands, Michael D, Bruce, James E, Pasa-Tolic, Ljiljana, and Smith, Richard D. Tue .
"Method for calibrating mass spectrometers". United States. https://www.osti.gov/servlets/purl/874962.
@article{osti_874962,
title = {Method for calibrating mass spectrometers},
author = {Anderson, Gordon A and Brands, Michael D and Bruce, James E and Pasa-Tolic, Ljiljana and Smith, Richard D},
abstractNote = {A method whereby a mass spectra generated by a mass spectrometer is calibrated by shifting the parameters used by the spectrometer to assign masses to the spectra in a manner which reconciles the signal of ions within the spectra having equal mass but differing charge states, or by reconciling ions having known differences in mass to relative values consistent with those known differences. In this manner, the mass spectrometer is calibrated without the need for standards while allowing the generation of a highly accurate mass spectra by the instrument.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {12}
}
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