Electrochemical methods for generation of a biological proton motive force and pyridine nucleotide cofactor regeneration

Zeikus, Gregory J; Shin, Hyoun S; Jain, Mahendra K

Title: Electrochemical methods for generation of a biological proton motive force and pyridine nucleotide cofactor regeneration

Abstract

Disclosed are methods using neutral red to mediate the interconversion of chemical and electrical energy. Electrically reduced neutral red has been found to promote cell growth and formation of reduced products by reversibly increasing the ratio of the reduced:oxidized forms of NAD(H) or NADP(H). Electrically reduced neutral red is able to serve as the sole source of reducing power for microbial, cell growth. Neutral red is also able to promote conversion of chemical energy to electrical energy by facilitating the transfer of electrons from microbial reducing power to a fuel cell cathode.

Inventors:

Zeikus, Gregory J ^[1]; Shin, Hyoun S ^[2]; Jain, Mahendra K ^[3]

Okemos, MI
Lansing, MI
Lexington, KY

Issue Date:: 2002-01-01

Research Org.:: Michigan State University (East Lansing, MI)

OSTI Identifier:: 874944

Patent Number(s):: 6495023

Assignee:: Michigan State University (East Lansing, MI)

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

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C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N13/00 - Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/004 - {mediator-assisted}

H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01M - PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
H01M8/16 - Biochemical fuel cells, i.e. cells in which microorganisms function as catalysts

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02E - REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
Y02E60/50 - Fuel cells

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DOE Contract Number:: FG02-93ER20108

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: electrochemical; methods; generation; biological; proton; motive; force; pyridine; nucleotide; cofactor; regeneration; disclosed; neutral; mediate; interconversion; chemical; electrical; energy; electrically; reduced; found; promote; cell; growth; formation; products; reversibly; increasing; ratio; reducedoxidized; forms; nadh; nadph; serve; sole; source; reducing; power; microbial; conversion; facilitating; transfer; electrons; fuel; cathode; fuel cell; electrical energy; chemical energy; electrochemical method; motive force; /205/

Citation Formats


                    Zeikus, Gregory J, Shin, Hyoun S, and Jain, Mahendra K. Electrochemical methods for generation of a biological proton motive force and pyridine nucleotide cofactor regeneration.  United States: N. p., 2002. 
        Web.

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                    Zeikus, Gregory J, Shin, Hyoun S, & Jain, Mahendra K. Electrochemical methods for generation of a biological proton motive force and pyridine nucleotide cofactor regeneration.  United States.

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                    Zeikus, Gregory J, Shin, Hyoun S, and Jain, Mahendra K. Tue .  
        "Electrochemical methods for generation of a biological proton motive force and pyridine nucleotide cofactor regeneration".  United States.  https://www.osti.gov/servlets/purl/874944.

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@article{osti_874944,

  title        = {Electrochemical methods for generation of a biological proton motive force and pyridine nucleotide cofactor regeneration},

  author       = {Zeikus, Gregory J and Shin, Hyoun S and Jain, Mahendra K},

  abstractNote = {Disclosed are methods using neutral red to mediate the interconversion of chemical and electrical energy. Electrically reduced neutral red has been found to promote cell growth and formation of reduced products by reversibly increasing the ratio of the reduced:oxidized forms of NAD(H) or NADP(H). Electrically reduced neutral red is able to serve as the sole source of reducing power for microbial, cell growth. Neutral red is also able to promote conversion of chemical energy to electrical energy by facilitating the transfer of electrons from microbial reducing power to a fuel cell cathode.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2002},

  month        = {1}

}

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Works referenced in this record:

Electrochemical studies on fermentation. I. Application of electro-energizing method to L-glutamic acid fermentation.
journal, January 1979

Hongo, Motoyoshi; Iwahara, Masayoshi
Agricultural and Biological Chemistry, Vol. 43, Issue 10
https://doi.org/10.1271/bbb1961.43.2075

Reduction of nitrate and nitrite in water by immobilized enzymes
journal, February 1992

Mellor, Robert B.; Ronnenberg, Jörg; Campbell, Wilbur H.
Nature, Vol. 355, Issue 6362
https://doi.org/10.1038/355717a0

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Title: Electrochemical methods for generation of a biological proton motive force and pyridine nucleotide cofactor regeneration

Abstract

Citation Formats

Electrochemical studies on fermentation. I. Application of electro-energizing method to L-glutamic acid fermentation. journal, January 1979

Reduction of nitrate and nitrite in water by immobilized enzymes journal, February 1992

Electrochemical studies on fermentation. I. Application of electro-energizing method to L-glutamic acid fermentation.
journal, January 1979

Reduction of nitrate and nitrite in water by immobilized enzymes
journal, February 1992