skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Optically generated ultrasound for enhanced drug delivery

Abstract

High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

Inventors:
 [1];  [2];  [3]
  1. Livermore, CA
  2. Baltimore, MD
  3. Danville, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
874886
Patent Number(s):
6484052
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
optically; generated; ultrasound; enhanced; drug; delivery; frequency; acoustic; waves; analogous; enhance; therapeutic; compounds; cells; delivered; chemotherapeutic; drugs; antibiotics; photodynamic; therapies; administered; systemically; locally; targeted; site; local; accomplished; needle; cannula; variety; vascular; catheters; depending; location; routes; access; systemic; near; target; compound; administration; produced; via; laser; radiation; interaction; absorbing; media; thermoelastic; expansion; thermodynamic; vaporization; material; ablation; plasma; formation; effect; temporarily; permeabilizing; membranes; increasing; diffusion; allowing; decreased; total; dosages; effects; enabling; laser radiation; acoustic wave; drug delivery; frequency acoustic; /604/606/

Citation Formats

Visuri, Steven R, Campbell, Heather L, and Da Silva, Luiz. Optically generated ultrasound for enhanced drug delivery. United States: N. p., 2002. Web.
Visuri, Steven R, Campbell, Heather L, & Da Silva, Luiz. Optically generated ultrasound for enhanced drug delivery. United States.
Visuri, Steven R, Campbell, Heather L, and Da Silva, Luiz. Tue . "Optically generated ultrasound for enhanced drug delivery". United States. https://www.osti.gov/servlets/purl/874886.
@article{osti_874886,
title = {Optically generated ultrasound for enhanced drug delivery},
author = {Visuri, Steven R and Campbell, Heather L and Da Silva, Luiz},
abstractNote = {High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

Patent:

Save / Share: