Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use
Abstract
The present invention provides a water-soluble luminescent quantum dot, a biomolecular conjugate thereof and a composition comprising such a quantum dot or conjugate. Additionally, the present invention provides a method of obtaining a luminescent quantum dot, a method of making a biomolecular conjugate thereof, and methods of using a biomolecular conjugate for ultrasensitive nonisotopic detection in vitro and in vivo.
- Inventors:
-
- Bloomington, IN
- Los Alamos, NM
- Issue Date:
- Research Org.:
- Indiana Univ., Bloomington, IN (United States)
- OSTI Identifier:
- 874824
- Patent Number(s):
- 6468808
- Assignee:
- Advanced Research and Technology Institute, Inc. (Indianapolis, IN)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- FG02-98ER14873
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- water-soluble; luminescent; quantum; dots; biomolecular; conjugates; related; compositions; method; provides; dot; conjugate; composition; comprising; additionally; obtaining; methods; ultrasensitive; nonisotopic; detection; vitro; vivo; /436/257/420/428/430/435/
Citation Formats
Nie, Shuming, Chan, Warren C. W., and Emory, Steven R. Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use. United States: N. p., 2002.
Web.
Nie, Shuming, Chan, Warren C. W., & Emory, Steven R. Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use. United States.
Nie, Shuming, Chan, Warren C. W., and Emory, Steven R. Tue .
"Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use". United States. https://www.osti.gov/servlets/purl/874824.
@article{osti_874824,
title = {Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use},
author = {Nie, Shuming and Chan, Warren C. W. and Emory, Steven R},
abstractNote = {The present invention provides a water-soluble luminescent quantum dot, a biomolecular conjugate thereof and a composition comprising such a quantum dot or conjugate. Additionally, the present invention provides a method of obtaining a luminescent quantum dot, a method of making a biomolecular conjugate thereof, and methods of using a biomolecular conjugate for ultrasensitive nonisotopic detection in vitro and in vivo.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}
Works referenced in this record:
Directionally Aligned Helical Peptides on Surfaces
journal, July 1993
- Whitesell, J. K.; Chang, H. K.
- Science, Vol. 261, Issue 5117
Electroluminescence from CdSe quantum‐dot/polymer composites
journal, March 1995
- Dabbousi, B. O.; Bawendi, M. G.; Onitsuka, O.
- Applied Physics Letters, Vol. 66, Issue 11
Quantum Dots as Inorganic DNA-Binding Proteins
journal, January 1996
- Murphy, Catherine J.; Brauns, Eric B.; Gearheart, Latha
- MRS Proceedings, Vol. 452
Size dependence of exciton fine structure in CdSe quantum dots
journal, June 1996
- Norris, D. J.; Efros, Al. L.; Rosen, M.
- Physical Review B, Vol. 53, Issue 24
The nucleation of receptor-mediated endocytosis.
journal, March 1996
- Edwards, D. A.; Gooch, K. J.; Zhang, I.
- Proceedings of the National Academy of Sciences, Vol. 93, Issue 5
Multicolor Spectral Karyotyping of Human Chromosomes
journal, July 1996
- Schrock, E.; du Manoir, S.; Veldman, T.
- Science, Vol. 273, Issue 5274
Synthesis and characterization of nearly monodisperse CdE (E = sulfur, selenium, tellurium) semiconductor nanocrystallites
journal, September 1993
- Murray, C. B.; Norris, D. J.; Bawendi, M. G.
- Journal of the American Chemical Society, Vol. 115, Issue 19, p. 8706-8715
Synthesis of Nanosized Gold−Silica Core−Shell Particles
journal, January 1996
- Liz-Marzán, Luis M.; Giersig, Michael; Mulvaney, Paul
- Langmuir, Vol. 12, Issue 18
Epitaxial Growth of Highly Luminescent CdSe/CdS Core/Shell Nanocrystals with Photostability and Electronic Accessibility
journal, July 1997
- Peng, Xiaogang; Schlamp, Michael C.; Kadavanich, Andreas V.
- Journal of the American Chemical Society, Vol. 119, Issue 30, p. 7019-7029
The band edge luminescence of surface modified CdSe nanocrystallites: Probing the luminescing state
journal, June 1997
- Kuno, M.; Lee, J. K.; Dabbousi, B. O.
- The Journal of Chemical Physics, Vol. 106, Issue 23
Semiconductor Clusters, Nanocrystals, and Quantum Dots
journal, February 1996
- Alivisatos, A. P.
- Science, Vol. 271, Issue 5251, p. 933-937
Quantum Confinement in Size-Selected, Surface-Oxidized Silicon Nanocrystals
journal, November 1993
- Wilson, W. L.; Szajowski, P. F.; Brus, L. E.
- Science, Vol. 262, Issue 5137
Photoluminescence wandering in single CdSe nanocrystals
journal, December 1996
- Blanton, Sean A.; Hines, Margaret A.; Guyot‐Sionnest, Philippe
- Applied Physics Letters, Vol. 69, Issue 25
(CdSe)ZnS Core−Shell Quantum Dots: Synthesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites
journal, November 1997
- Dabbousi, B. O.; Rodriguez-Viejo, J.; Mikulec, F. V.
- The Journal of Physical Chemistry B, Vol. 101, Issue 46, p. 9463-9475
Small-particle research: physicochemical properties of extremely small colloidal metal and semiconductor particles
journal, December 1989
- Henglein, Arnim
- Chemical Reviews, Vol. 89, Issue 8
Synthesis and Characterization of Strongly Luminescing ZnS-Capped CdSe Nanocrystals
journal, January 1996
- Hines, Margaret A.; Guyot-Sionnest, Philippe
- The Journal of Physical Chemistry, Vol. 100, Issue 2, p. 468-471
Characterization of quantum-confined CdS nanocrystallites stabilized by deoxyribonucleic acid (DNA)
journal, April 1992
- Coffer, J. L.; Bigham, S. R.; Pinizzotto, R. F.
- Nanotechnology, Vol. 3, Issue 2
Radiofrequency Encoded Combinatorial Chemistry
journal, November 1995
- Nicolaou, K. C.; Xiao, Xiao-Yi; Parandoosh, Zahra
- Angewandte Chemie International Edition in English, Vol. 34, Issue 20, p. 2289-2291
Fluorescence intermittency in single cadmium selenide nanocrystals
journal, October 1996
- Nirmal, M.; Dabbousi, B. O.; Bawendi, M. G.
- Nature, Vol. 383, Issue 6603
Surface Derivatization of Nanocrystalline CdSe Semiconductors
journal, January 1996
- Lee, J. -K.; Kuno, M.; Bawendi, M. G.
- MRS Proceedings, Vol. 452
Preparation of Monodisperse CdS Nanocrystals by Size Selective Photocorrosion
journal, January 1996
- Matsumoto, Hajime; Sakata, Takao; Mori, Hirotaro
- The Journal of Physical Chemistry, Vol. 100, Issue 32
Measurement and assignment of the size-dependent optical spectrum in CdSe quantum dots
journal, June 1996
- Norris, D. J.; Bawendi, M. G.
- Physical Review B, Vol. 53, Issue 24
Light-emitting diodes made from cadmium selenide nanocrystals and a semiconducting polymer
journal, August 1994
- Colvin, V. L.; Schlamp, M. C.; Alivisatos, A. P.
- Nature, Vol. 370, Issue 6488
The mechanism of receptor-mediated endocytosis
journal, December 1991
- Smythe, Elizabeth; Warren, Graham
- European Journal of Biochemistry, Vol. 202, Issue 3
Synthesis of Luminescent Thin-Film CdSe/ZnSe Quantum Dot Composites Using CdSe Quantum Dots Passivated with an Overlayer of ZnSe
journal, January 1996
- Danek, Michal; Jensen, Klavs F.; Murray, Chris B.
- Chemistry of Materials, Vol. 8, Issue 1
Organization of 'nanocrystal molecules' using DNA
journal, August 1996
- Alivisatos, A. Paul; Johnsson, Kai P.; Peng, Xiaogang
- Nature, Vol. 382, Issue 6592
Photoluminescence Spectroscopy of Single CdSe Nanocrystallite Quantum Dots
journal, October 1996
- Empedocles, S. A.; Norris, D. J.; Bawendi, M. G.
- Physical Review Letters, Vol. 77, Issue 18
Perspectives on the Physical Chemistry of Semiconductor Nanocrystals
journal, January 1996
- Alivisatos, A. P.
- The Journal of Physical Chemistry, Vol. 100, Issue 31
Colloidal Semiconductor Q-Particles: Chemistry in the Transition Region Between Solid State and Molecules
journal, January 1993
- Weller, Horst
- Angewandte Chemie International Edition in English, Vol. 32, Issue 1
Bifunctional Capping of CdS Nanoparticles and Bridging to TiO2
journal, June 1995
- Lawless, Darren; Kapoor, Sudhir; Meisel, Dan
- The Journal of Physical Chemistry, Vol. 99, Issue 25, p. 10329-10335
X-ray Photoelectron Spectroscopy of CdSe Nanocrystals with Applications to Studies of the Nanocrystal Surface
journal, April 1994
- Katari, J. E. Bowen; Colvin, V. L.; Alivisatos, A. P.
- The Journal of Physical Chemistry, Vol. 98, Issue 15
Quantum crystallites and nonlinear optics
journal, December 1991
- Brus, L.
- Applied Physics A Solids and Surfaces, Vol. 53, Issue 6
Preferential Adsorption of a “Kinked” DNA to a Neutral Curved Surface: Comparisons to and Implications for Nonspecific DNA−Protein Interactions
journal, January 1996
- Mahtab, Rahina; Rogers, Jessica P.; Singleton, Chainey P.
- Journal of the American Chemical Society, Vol. 118, Issue 30