skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use

Abstract

The present invention provides a water-soluble luminescent quantum dot, a biomolecular conjugate thereof and a composition comprising such a quantum dot or conjugate. Additionally, the present invention provides a method of obtaining a luminescent quantum dot, a method of making a biomolecular conjugate thereof, and methods of using a biomolecular conjugate for ultrasensitive nonisotopic detection in vitro and in vivo.

Inventors:
 [1];  [1];  [2]
  1. Bloomington, IN
  2. Los Alamos, NM
Issue Date:
Research Org.:
Indiana Univ., Bloomington, IN (United States)
OSTI Identifier:
874824
Patent Number(s):
6468808
Assignee:
Advanced Research and Technology Institute, Inc. (Indianapolis, IN)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
FG02-98ER14873
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
water-soluble; luminescent; quantum; dots; biomolecular; conjugates; related; compositions; method; provides; dot; conjugate; composition; comprising; additionally; obtaining; methods; ultrasensitive; nonisotopic; detection; vitro; vivo; /436/257/420/428/430/435/

Citation Formats

Nie, Shuming, Chan, Warren C. W., and Emory, Steven R. Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use. United States: N. p., 2002. Web.
Nie, Shuming, Chan, Warren C. W., & Emory, Steven R. Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use. United States.
Nie, Shuming, Chan, Warren C. W., and Emory, Steven R. Tue . "Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use". United States. https://www.osti.gov/servlets/purl/874824.
@article{osti_874824,
title = {Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use},
author = {Nie, Shuming and Chan, Warren C. W. and Emory, Steven R},
abstractNote = {The present invention provides a water-soluble luminescent quantum dot, a biomolecular conjugate thereof and a composition comprising such a quantum dot or conjugate. Additionally, the present invention provides a method of obtaining a luminescent quantum dot, a method of making a biomolecular conjugate thereof, and methods of using a biomolecular conjugate for ultrasensitive nonisotopic detection in vitro and in vivo.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

Patent:

Save / Share:

Works referenced in this record:

Directionally Aligned Helical Peptides on Surfaces
journal, July 1993


Electroluminescence from CdSe quantum‐dot/polymer composites
journal, March 1995


Electronic Energy Transfer in CdSe Quantum Dot Solids
journal, April 1996


Quantum Dots as Inorganic DNA-Binding Proteins
journal, January 1996


Size dependence of exciton fine structure in CdSe quantum dots
journal, June 1996


The nucleation of receptor-mediated endocytosis.
journal, March 1996


Multicolor Spectral Karyotyping of Human Chromosomes
journal, July 1996


Synthesis and characterization of nearly monodisperse CdE (E = sulfur, selenium, tellurium) semiconductor nanocrystallites
journal, September 1993


Synthesis of Nanosized Gold−Silica Core−Shell Particles
journal, January 1996


Epitaxial Growth of Highly Luminescent CdSe/CdS Core/Shell Nanocrystals with Photostability and Electronic Accessibility
journal, July 1997

  • Peng, Xiaogang; Schlamp, Michael C.; Kadavanich, Andreas V.
  • Journal of the American Chemical Society, Vol. 119, Issue 30, p. 7019-7029
  • https://doi.org/10.1021/ja970754m

The band edge luminescence of surface modified CdSe nanocrystallites: Probing the luminescing state
journal, June 1997


Semiconductor Clusters, Nanocrystals, and Quantum Dots
journal, February 1996


Quantum Confinement in Size-Selected, Surface-Oxidized Silicon Nanocrystals
journal, November 1993


Photoluminescence wandering in single CdSe nanocrystals
journal, December 1996


(CdSe)ZnS Core−Shell Quantum Dots: Synthesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites
journal, November 1997


Synthesis and Characterization of Strongly Luminescing ZnS-Capped CdSe Nanocrystals
journal, January 1996


Characterization of quantum-confined CdS nanocrystallites stabilized by deoxyribonucleic acid (DNA)
journal, April 1992


Radiofrequency Encoded Combinatorial Chemistry
journal, November 1995


Fluorescence intermittency in single cadmium selenide nanocrystals
journal, October 1996


Surface Derivatization of Nanocrystalline CdSe Semiconductors
journal, January 1996


Preparation of Monodisperse CdS Nanocrystals by Size Selective Photocorrosion
journal, January 1996


Measurement and assignment of the size-dependent optical spectrum in CdSe quantum dots
journal, June 1996


Light-emitting diodes made from cadmium selenide nanocrystals and a semiconducting polymer
journal, August 1994


The mechanism of receptor-mediated endocytosis
journal, December 1991


Synthesis of Luminescent Thin-Film CdSe/ZnSe Quantum Dot Composites Using CdSe Quantum Dots Passivated with an Overlayer of ZnSe
journal, January 1996


Organization of 'nanocrystal molecules' using DNA
journal, August 1996


Photoluminescence Spectroscopy of Single CdSe Nanocrystallite Quantum Dots
journal, October 1996


Perspectives on the Physical Chemistry of Semiconductor Nanocrystals
journal, January 1996


Colloidal Semiconductor Q-Particles: Chemistry in the Transition Region Between Solid State and Molecules
journal, January 1993


Bifunctional Capping of CdS Nanoparticles and Bridging to TiO2
journal, June 1995


X-ray Photoelectron Spectroscopy of CdSe Nanocrystals with Applications to Studies of the Nanocrystal Surface
journal, April 1994


Quantum crystallites and nonlinear optics
journal, December 1991


Preferential Adsorption of a “Kinked” DNA to a Neutral Curved Surface:  Comparisons to and Implications for Nonspecific DNA−Protein Interactions
journal, January 1996