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Title: Flowmeter for pressure-driven chromatography systems

Abstract

A flowmeter for accurately measuring the flowrate of fluids in high pressure chromatography systems. The flowmeter is a porous bed of a material, the porous bed having a porosity in the range of about 0.1 to 0.6 and a pore size in the range of about 50 nm to 1 .mu.m, disposed between a high pressure pumping means and a chromatography column. The flowmeter is provided with pressure measuring means at both the inlet and outlet of the porous bed for measuring the pressure drop through the porous bed. This flowmeter system provides not only the ability to measure accurately flowrates in the range of .mu.L/min to nL/min but also to provide a signal that can be used for a servo loop or feedback control system for high pressure pumping systems.

Inventors:
 [1];  [1]
  1. Livermore, CA
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
OSTI Identifier:
874788
Patent Number(s):
6460420
Assignee:
Sandia National Laboratories (Livermore, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01F - MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
flowmeter; pressure-driven; chromatography; systems; accurately; measuring; flowrate; fluids; pressure; porous; bed; material; porosity; range; 01; 06; pore; size; 50; nm; mum; disposed; pumping; means; column; provided; inlet; outlet; drop; provides; ability; measure; flowrates; mulmin; nlmin; provide; signal; servo; loop; feedback; control; pore size; chromatography column; pressure pump; porous bed; /73/210/

Citation Formats

Paul, Phillip H, and Arnold, Don W. Flowmeter for pressure-driven chromatography systems. United States: N. p., 2002. Web.
Paul, Phillip H, & Arnold, Don W. Flowmeter for pressure-driven chromatography systems. United States.
Paul, Phillip H, and Arnold, Don W. Tue . "Flowmeter for pressure-driven chromatography systems". United States. https://www.osti.gov/servlets/purl/874788.
@article{osti_874788,
title = {Flowmeter for pressure-driven chromatography systems},
author = {Paul, Phillip H and Arnold, Don W},
abstractNote = {A flowmeter for accurately measuring the flowrate of fluids in high pressure chromatography systems. The flowmeter is a porous bed of a material, the porous bed having a porosity in the range of about 0.1 to 0.6 and a pore size in the range of about 50 nm to 1 .mu.m, disposed between a high pressure pumping means and a chromatography column. The flowmeter is provided with pressure measuring means at both the inlet and outlet of the porous bed for measuring the pressure drop through the porous bed. This flowmeter system provides not only the ability to measure accurately flowrates in the range of .mu.L/min to nL/min but also to provide a signal that can be used for a servo loop or feedback control system for high pressure pumping systems.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

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Works referenced in this record:

First-principles calculations of dynamic permeability in porous media
journal, June 1989


Coalescence of Oil-in-Water Suspensions by Flow through Porous Media
journal, May 1977


Modelling of porous media by renormalization of the Stokes equations
journal, May 1985


Solute Transfer Through Columns of Glass Beads
journal, February 1984