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Title: Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable

This invention relates to using customized oligonucleotide microchips as biosensors for the detection and identification of nucleic acids specific for different genes, organisms and/or individuals in the environment, in food and in biological samples. The microchips are designed to convert multiple bits of genetic information into simpler patterns of signals that are interpreted as a unit. Because of an improved method of hybridizing oligonucleotides from samples to microchips, microchips are reusable and transportable. For field study, portable laser or bar code scanners are suitable.
Inventors:
 [1];  [2];  [3];  [4];  [5];  [6];  [6]
  1. (Darien, IL)
  2. (Rockville, MD)
  3. (Woodridge, IL)
  4. (Elektrosol, RU)
  5. (Cambridge, MA)
  6. (Hinsdale, IL)
Issue Date:
OSTI Identifier:
874779
Assignee:
University of Chicago (Chicago, IL) ANL
Patent Number(s):
US 6458584
Contract Number:
W-31109-ENG-38
Research Org:
Argonne National Laboratory (ANL), Argonne, IL
Country of Publication:
United States
Language:
English
Subject:
customized; oligonucleotide; microchips; convert; multiple; genetic; information; simple; patterns; portable; reusable; relates; biosensors; detection; identification; nucleic; acids; specific; genes; organisms; andor; individuals; environment; food; biological; samples; designed; bits; simpler; signals; interpreted; unit; improved; method; hybridizing; oligonucleotides; transportable; field; study; laser; bar; code; scanners; nucleic acid; /435/999/