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Title: Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable

Abstract

This invention relates to using customized oligonucleotide microchips as biosensors for the detection and identification of nucleic acids specific for different genes, organisms and/or individuals in the environment, in food and in biological samples. The microchips are designed to convert multiple bits of genetic information into simpler patterns of signals that are interpreted as a unit. Because of an improved method of hybridizing oligonucleotides from samples to microchips, microchips are reusable and transportable. For field study, portable laser or bar code scanners are suitable.

Inventors:
 [1];  [2];  [3];  [4];  [5];  [6];  [6]
  1. Darien, IL
  2. Rockville, MD
  3. Woodridge, IL
  4. Elektrosol, RU
  5. Cambridge, MA
  6. Hinsdale, IL
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
OSTI Identifier:
874779
Patent Number(s):
6458584
Assignee:
University of Chicago (Chicago, IL)
Patent Classifications (CPCs):
G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16B - BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
W-31109-ENG-38
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
customized; oligonucleotide; microchips; convert; multiple; genetic; information; simple; patterns; portable; reusable; relates; biosensors; detection; identification; nucleic; acids; specific; genes; organisms; andor; individuals; environment; food; biological; samples; designed; bits; simpler; signals; interpreted; unit; improved; method; hybridizing; oligonucleotides; transportable; field; study; laser; bar; code; scanners; nucleic acid; /435/999/

Citation Formats

Mirzabekov, Andrei, Guschin, Dmitry Y, Chik, Valentine, Drobyshev, Aleksei, Fotin, Alexander, Yershov, Gennadiy, and Lysov, Yuri. Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable. United States: N. p., 2002. Web.
Mirzabekov, Andrei, Guschin, Dmitry Y, Chik, Valentine, Drobyshev, Aleksei, Fotin, Alexander, Yershov, Gennadiy, & Lysov, Yuri. Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable. United States.
Mirzabekov, Andrei, Guschin, Dmitry Y, Chik, Valentine, Drobyshev, Aleksei, Fotin, Alexander, Yershov, Gennadiy, and Lysov, Yuri. Tue . "Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable". United States. https://www.osti.gov/servlets/purl/874779.
@article{osti_874779,
title = {Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable},
author = {Mirzabekov, Andrei and Guschin, Dmitry Y and Chik, Valentine and Drobyshev, Aleksei and Fotin, Alexander and Yershov, Gennadiy and Lysov, Yuri},
abstractNote = {This invention relates to using customized oligonucleotide microchips as biosensors for the detection and identification of nucleic acids specific for different genes, organisms and/or individuals in the environment, in food and in biological samples. The microchips are designed to convert multiple bits of genetic information into simpler patterns of signals that are interpreted as a unit. Because of an improved method of hybridizing oligonucleotides from samples to microchips, microchips are reusable and transportable. For field study, portable laser or bar code scanners are suitable.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

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