Microfabricated injectable drug delivery system
Abstract
A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.
- Inventors:
-
- Pleasanton, CA
- Oakland, CA
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- OSTI Identifier:
- 874750
- Patent Number(s):
- 6454759
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- microfabricated; injectable; drug; delivery; integrated; capable; secreting; controlled; dosages; multiple; drugs; periods; time; device; narrow; shaped; implant; sharp; leading; edge; implantation; human; manner; analogous; sliver; micromachined; zero; power; constant; pressure; generating; osmotic; engine; addressable; one-shot; shape; memory; polymer; smp; valves; switching; outlet; ports; pistons; isolating; source; drug-filled; microchannels; drugmultiple; dosage; capacity; anisotropically-etched; atomically-sharp; silicon; penetrating; externally; mounted; controller; controlling; on-board; electronics; activates; microvalves; etc; leading edge; drug delivery; /604/424/
Citation Formats
Krulevitch, Peter A, and Wang, Amy W. Microfabricated injectable drug delivery system. United States: N. p., 2002.
Web.
Krulevitch, Peter A, & Wang, Amy W. Microfabricated injectable drug delivery system. United States.
Krulevitch, Peter A, and Wang, Amy W. Tue .
"Microfabricated injectable drug delivery system". United States. https://www.osti.gov/servlets/purl/874750.
@article{osti_874750,
title = {Microfabricated injectable drug delivery system},
author = {Krulevitch, Peter A and Wang, Amy W},
abstractNote = {A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 2002},
month = {Tue Jan 01 00:00:00 EST 2002}
}
Works referenced in this record:
Thin film shape memory alloy microactuators
journal, January 1996
- Krulevitch, P.; Lee, A. P.; Ramsey, P. B.
- Journal of Microelectromechanical Systems, Vol. 5, Issue 4